Pharmacological Screening of Euphorbia Neriifolia Leaf Hydroalcoholic Extract

Abstract

Pharmacological screening of Euphorbia neriifolia Linn. (Euphorbiaceous) leaf hydro alcoholic extract were performed to explore the analgesic, anti-inflammatory, diuretic, antidiarrhoeal and antiulcer activities. All tests were conducted on rats using 100, 200 and 400 mg/kg dose as LD 50 of extract was found to 2779.71 mg/kg. Study revealed strong analgesic effect of E. neriifolia against thermal (P<0.001), and in mechanical and chemical (p < 0.01) noxious stimuli and anti-inflammatory activity (P<0.001 to 0.01) at the 1000 mg/kg dose. In carrageenan-induced paw edema and cotton pellet induced granuloma model E. neriifolia extract showed significant (P<0.001 to 0.01) antiinflammatory activity. Extract considerably increases urine volume as an effective hypernatraemic and hyperchloraemic diuretic. E. neriifolia showed laxative property by increasing wet defecation along with castor oil. Extract showed very prominent protection against ethanol-induced ulceration as well as on pyloric ligated ulceration in dose dependent manner. Extract increases total hexoses (P<0.001), hexosamine (P<0.05), sialic acid and total carbohydrate content (P<0.001) with a decrease in total protein content (P<0.001) of gastric mucosa at 400 mg/kg dose. Presence of phytoconstituents like tannins, flavonoids, alkaloids and triterpenoidal saponins may be responsible for the found pharmacological activities.

Review on Euphorbia neriifolia Plant

“…The collected urine sample were tested for concentration of Na+ and K+ by flame photometer, the tested samples increases the urine volume as an effective hypermatraemic and hypercholaemic diuretic [7,52]. m. The anti-diabetic and anti-hyperlipidemic activity of ethanolic extract of leaves of E. neriifolia was studied on the type-2 diabetic rats.…”

Pharmacognostical and Physico-chemical Standardization of Euphorbia neriifolia Leaves

“…anti-anxiety / anti-convulsant / anti-psychotic, 10 anti-arthritis, 11 anti-carcinogenic / renal carcinogenesis / hepatocarcinogenesis, [12][13][14][15] antidiabetic, 16 anti-inflammatory, 8,9,17,18 antioxidant, 19,20 cytotoxicity, 21,22 death-receptor expression enhancing activity, 23 immunomodulatory, 24,25 etc. properties.…”

Corrosion Inhibition of Aluminium by Alkaloid Extract of Aerial Part of Euphorbia neriifolia Linn in HCl Solutions

“…The whole plant is very useful and the extract of plant contains; tannins, sugar, flavonoids, alkaloids, triterpenoids, saponins, etc. (17)(18)(19)(20)(21)(22)(23)…”

“…The plant (including stem, leaves and flower) was air dried at room temperature, then grinded to make powder. The extract of powder stem, powder leaves and powder flower were obtained by refluxing the dried powder in soxhlet unit in ethanol solvent with refluxing by heating for sufficient time (15)(16)(17)(18)(19)(20) hrs.…”