2006
DOI: 10.2174/156802606777323764
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Pharmacological Roles of the Large-Conductance Calcium-Activated Potassium Channel

Abstract: The gating of large-conductance Ca(2+)-activated K(+) (BK(Ca)) channel is primarily controlled by intracellular Ca(2+) and/or membrane depolarization. These channels play a role in the coupling of excitation-contraction and stimulus-secretion. A variety of structurally distinct compounds may influence the activity of these channels. Squamocin, an Annonaceous acetogenin, could interact with the BK(Ca) channel to increase the amplitude of Ca(2+)-activated K(+) current in coronary smooth muscle cells. Its stimula… Show more

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Cited by 26 publications
(23 citation statements)
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References 61 publications
(75 reference statements)
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“…To detect the activity of BK Ca channels, cells were bathed in high-K + solution which contained 1.8 mM CaCl 2 . Consistent with previous observations [7,33], as the cells were held at +60 mV, BK Ca -channel activity can be readily detected (Fig. 8).…”
Section: Effects Of Oxal On Single-channel Conductance Of Ik Ca Channelssupporting
confidence: 92%
“…To detect the activity of BK Ca channels, cells were bathed in high-K + solution which contained 1.8 mM CaCl 2 . Consistent with previous observations [7,33], as the cells were held at +60 mV, BK Ca -channel activity can be readily detected (Fig. 8).…”
Section: Effects Of Oxal On Single-channel Conductance Of Ik Ca Channelssupporting
confidence: 92%
“…BK Cachannel activity was noted to be active at the level of resting potential (Wu et al 2006). Therefore, it is anticipated that the inhibition of BK Ca channels and I K(erg) in pituitary lactotrophs caused by DEHP or other phthalate esters may synergistically act to affect the functional activity of these cells in vivo (Wu et al 2000).…”
Section: Discussionmentioning
confidence: 99%
“…However, no significant change in the single-channel conductance was seen in the presence of DEHP. Alternatively, verruculogen (1 lM), known to block BK Ca channels (Wu et al 2006), was effective in decreasing channel activity in these cells (Fig. 7b).…”
Section: Lack Of Effect Of Dehp On I K(dr) In Gh 3 Cellsmentioning
confidence: 91%
“…The channel is unique in that it can be dually activated by membrane depolarization and elevations in intracellular Ca 2ϩ concentrations. Organic compounds with varying structures capable of activating BK Ca channels have been reported previously (Calderone, 2002;Wu et al, 2006;Nardi and Olesen, 2008). Because of their unique high conductance (ϳ200 pS), even at low probability of opening, sufficient current could flow, thereby altering the membrane potential of excitable cells.…”
mentioning
confidence: 99%