Pharmacological responsiveness of dermatitis secondary to compulsive washing

Pharmacological Interventions for Primary Psychodermatologic Disorders: An Evidence Mapping and Appraisal of Randomized Controlled Trials

“…38 patients (78.9% females) with dermatitis from compulsive hand washing were randomized into a clomipramine group ( n = 17) or a placebo group ( n = 21). 32 At the end of the 10 week treatment with oral clomipramine (dosage was not provided), 65.0% of the patients in the clomipramine group had improvement in their dermatitis assessed by physicians, which is significantly higher than those receiving placebo (29.0%) ( P < .001). Independent of dermatological improvement, clomipramine also significantly improved the scores in YBOCS ( P < .001).…”

“…Among the 21 studies published from 1982 to 2019, 16 were conducted in the US, 17 - 32 one in Canada, 33 one in the Netherlands, 34 one in Denmark, 35 and two in Iran. 36 , 37 Five PDDs were identified: trichotillomania ( n = 12 studies), 17 - 26 , 33 , 34 skin picking ( n =5), 27 - 30 , 36 nail biting ( n = 2), 31 , 37 delusional parasitosis ( n = 1), 35 and dermatitis from compulsive hand washing ( n = 1).…”

“…36 , 37 Five PDDs were identified: trichotillomania ( n = 12 studies), 17 - 26 , 33 , 34 skin picking ( n =5), 27 - 30 , 36 nail biting ( n = 2), 31 , 37 delusional parasitosis ( n = 1), 35 and dermatitis from compulsive hand washing ( n = 1). 32 Seven different classes of medications were investigated: SSRIs (i.e., fluoxetine, sertraline, and citalopram), tricyclic antidepressants (i.e., clomipramine and desipramine), antipsychotics (i.e., olanzapine and pimozide), anticonvulsants (i.e., lamotrigine), N-acetylcysteine (NAC), inositol, and milk thistle. Supplemental Table 1 provides a summary of safety and side effects for the investigated interventions ( Supplemental Table 3 summarizes the characteristics of all studies and the investigated outcomes measures).…”