Pharmacological reflection of plants traditionally used to manage diabetes mellitus in Tanzania

Peter, Emanuel L.; Nagendrappa, Prakash B.; Hilonga, S.; Tuyiringire, Naasson; Ashuro, Efrata; Kaligirwa, Anita; Sesaazi, Duncan C.

doi:10.1016/j.jep.2020.113715

Cited by 7 publications

(9 citation statements)

References 108 publications

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“…This suggests that medicinal plants are key alternatives to the currently available conventional DM medicines. Consistent with our findings, several other researchers have also reported dominant use of plant species belonging to Fabaceae and Asteraceae families for treatment of DM in other countries, such as Nigeria and Tanzania [13,31,32]. Furthermore, studies have also shown that same plants are used similarly for DM treatment in neighboring and other countries (Table 2), for instance, the use of Erythrina abyssinica DC.…”

Section: Plants Used For Treating Dm In Ugandasupporting

confidence: 91%

“…C.D.Adams, and Ageratum conyzoides (L.) L. (all in Asteraceae) were documented to be used traditionally for treating DM in Nigeria [31,33]. Cajanus cajan (L.) Huth (Fabaceae) has been used to treat DM in Tanzania [32].…”

Section: Plants Used For Treating Dm In Ugandamentioning

confidence: 99%

“…The mechanisms of action included decreasing blood sugar Justicia betonica L Kenya Inflammation Whole plant [76] Tanzania stomach ache Whole plant [77] Kigelia africana (Lam.) Benth Kenya Measles Fruits [58] Tanzania DM and mental illness Fruits [32] DR Congo DM, male impotence, and vaginal infections…”

Section: In Vitro and In Vivo Studiesmentioning

confidence: 99%

“…Iwarsson Kenya DM, coughing, and asthma Roots [80] Mondia whitei (Hook.f.) Skeels Kenya Aphrodisiac, ringworms, skin diseases, stomach worms, heart diseases, and asthma Roots [58,81] Tanzania Abdominal pain and facilitate child birth Roots [82] DR Congo Erectile dysfunction Leaves and roots [83] Moringa oleifera Lam Kenya Arthritis/gouts, loss of memory, prostate cancer, and high blood pressure Seeds and leaves [84] Tanzania DM Flowers, Pods, seeds, roots, and leaves [32] DR Congo DM, cataract eye, conjunctivitis, and malaria Leaves and flowers [39] Oxalis corniculata L Kenya Skin infections Leaves [85] Tanzania Stomach upset, rusts, and wounds Leaves [86] Rwanda Asthama Aerial parts [60] Persea americana Mill Kenya DM Leaves [87] Tanzania DM Seeds and whole plant [32] Rwanda Liver diseases Not recorded [67] DR Congo DM, anemia, constipation, diarrhea, fever, pain, and sickle cell Leaves, stem bark, and fruits [39] Phoenix reclinata Jacq Kenya Male reproductive dysfunctions Roots [61] Tanzania Epilepsy, eye troubles, stomach aches, pleuritic pains and pleurisy Roots, leaves, and thorn [88] Pseudospondias microcarpa Engl Tanzania Peptic ulcers and malaria Stem bark [36,89] DR Congo Malaria Stem bark and root bark [89] via stimulation of pancreatic β-cells [116,117], inhibition of α-amylase, α-glucosidase, DPP-IV, insulinase, and aldose reductase enzymes activities [118][119][120][121], increasing expression of glucose transporters [122,123], and enhancement of the affinity as well as sensitivity of insulin receptors [124]. Additionally, the plants acted through increase of glucose utilization within several tissues and organs [125], resistance of lipid peroxidation [126][127]…”

Section: In Vitro and In Vivo Studiesmentioning

confidence: 99%

“…Not recorded [36] DR Congo DM, amoebiasis, diarrhea, dysentery, and female infertility Roots and leaves [39] Schkuhria pinnata (Lam.) Kuntze ex Thell Kenya Malaria Whole plant [91] Tanzania Gastrointestinal remedies Whole plant [92] Sesbania sesban (L.) Merr Kenya Throat/stomach/oesophageal cancer Whole plant [41] Tanzania Venereal diseases Leaves [93] Rwanda Gonorrhea, syphilis, and conjunctivitis Leaves [57] Solanum aethiopicum L DR Congo DM and abdominal pain Roots, fruits, leaves, and seeds [39] Solanum melongena L DR Congo DM Fruits [94] Steganotaenia araliacea Hochst Kenya DM Leaves [44] Tanzania Herpes zoster and HIV/AIDS Areal parts [36] DR Congo DM Not recorded [95] Syzygium cumini (L.) Skeels Tanzania DM Stem bark [32] DR Congo DM Fruits [39] Tithonia diversifolia (Hemsl.) A.Gray Kenya Stomach pains and typhoid Leaves [96] Tanzania Skin infections, stomach problem Leaves [93] DR Congo DM, amoebiasis, anorexia, asthenia, constipation, and splenomegaly Leaves [39] Toddalia asiatica (L.) Lam Kenya Abdominal pains, gynaecologic disorders such as infertility, common colds, cancer, and renal disorders Roots and leaves [97] Tanzania Stomach problems and malaria Root bark, stem bark, leaves, and fruits [98] Vernonia amygdalina Del Kenya Abdominal pains in infants and in pregnancy, arthritis, meningitis, malaria, typhoid, and epilepsy Roots [97] Tanzania Febrile convulsions, fever, and malaria Roots and leaves [36] Rwanda Gastroenteritis Leaves [57] DR Congo DM, dysentery, gallstone, gastritis, helminthiasis, headache, hepatitis, malaria, poisoning antidote, rashes with itching, scabies, and tuberculosis Leaves [39] Vigna unguiculata (L.) Walp Kenya Obesity Leaves [99] Tanzania Anemia Leaves and seeds [100] DR Congo Sickle cell Leaves [101] Warburgia ugandensis Sprague Kenya DM, malaria, and pneumonia Leaves [102] Tanzania Toothache, cough, fever, general body pains, anthelmintic, and malaria Roots and stem bark [103] DR Congo Democratic Republic of the Congo; DM Diabetes mellitus;...…”

Section: In Vitro and In Vivo Studiesmentioning

confidence: 99%

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Ethnomedicine and ethnopharmacology of medicinal plants used in the treatment of diabetes mellitus in Uganda

et al. 2023

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Diabetes mellitus (DM) is a global health problem owing to its high prevalence and increased morbidity and mortality. The prevalence of DM and impaired glucose tolerance in Uganda is approximately 4.1% and 6.6%, respectively. Medicinal plants are commonly used for the management of DM, especially in developing countries, such as Uganda. According to several ethnobotanical surveys conducted in Uganda, various medicinal plants are used in DM management. Meanwhile, ethnopharmacological studies have confirmed the anti-diabetic efficacy of various plants and plant-derived formulations from Uganda. However, these information remain highly fragmented without a single repository for plants used in the management and treatment of DM in Uganda, hindering further investigations. Therefore, this study aimed to comprehensively explore plants used for DM treatment in Uganda and retrieve relevant ethnopharmacological and ethnomedicinal information that can be used for DM therapy development. English peer-reviewed articles and books were searched in scientific databases, especially PubMed, Scopus, Google Scholar, Science Direct, SciFinder, and Medline, to retrieve information on medicinal plants used for DM treatment and management in Uganda. The databases were searched to obtain published literature on the anti-diabetic activities and safety of plants among the identified plants. The family name, plant parts used, anti-diabetic activities, dosage, and mechanisms of action of plant extracts were captured. In total, 46 species belonging to 26 families are used to treat DM in Uganda. Most species belonged to the Fabaceae (20%), Asteraceae (13%), and Solanaceae (7%) families. Anti-diabetic activities of 27 (59%) species have been scientifically investigated, whereas the rest have not been evaluated. This review indicated that various medicinal plants are used in the traditional treatment and management of DM across different regions in Uganda. Scientific investigations have revealed the anti-diabetic potential and safety of several of these plants. However, there is a need to validate the anti-diabetic potential of other unstudied plants. Additionally, isolating and characterizing active principles and elucidating the anti-diabetic mechanism of these plants and performing preclinical and clinical studies in the future could aid in the formulation of an effective and safe treatment for DM.

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Section: Plants Used For Treating Dm In Ugandasupporting

confidence: 91%

Section: Plants Used For Treating Dm In Ugandamentioning

confidence: 99%

Section: In Vitro and In Vivo Studiesmentioning

confidence: 99%

Section: In Vitro and In Vivo Studiesmentioning

confidence: 99%

Section: In Vitro and In Vivo Studiesmentioning

confidence: 99%

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Ethnomedicine and ethnopharmacology of medicinal plants used in the treatment of diabetes mellitus in Uganda

et al. 2023

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Ethnobotany, pharmacology and phytochemistry of medicinal plants used for management of Diabetes mellitus in Uganda, Kenya, Tanzania and the Democratic Republic of Congo

Dangana,

Abubakar,

Shinkafi

et al. 2024

Discov Appl Sci

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Ethnopharmacological relevance For decades, patients in East Africa have used herbal medicine as an alternative and affordable therapeutic option for the treatment of diseases such as Diabetes Mellitus (DM). As a result, the primary objective of this research was to thoroughly investigate the plants employed for treating DM in Uganda, Tanzania, Kenya, and the Democratic Republic of Congo and gather pertinent ethnopharmacological and ethnomedicinal knowledge that could be applied in the development of therapies for DM. Aim of the study The study is aimed at critically reviewing the phytochemistry, pharmacology, and toxicology of medicinal plants used for treating diabetes in East African countries, including Uganda, Tanzania, Kenya, and the Democratic Republic of Congo. Method A search for relevant articles was conducted on PubMed, ISI Web of Science, Open Theses, Google Scholar, Science Direct, and Scopus, and the identified articles were evaluated for quality, relevance, and taxonomical accuracy before undergoing review. Results The study identified 140 plant species used by local communities for the management of DM in East Africa, with decoction and infusion being the most common preparation methods. The leaves, root, and stem bark were the most frequently used parts. The in vitro and in vivo studies demonstrated the antidiabetic effect of medicinal plants such as Kigelia Africana, Hagenia abyssinica (Rosaceae), Physalis peruviana among other plants used for herbal treatment elicited via stimulation of insulin release, and gluconeogenesis. Phytochemicals present were mainly flavonoids, alkaloids, saponins, tannins, and glycosides. Conclusion The local communities in Uganda, Tanzania, Kenya and the Democratic Republic of Congo use herbal medicine for managing DM, but only a fraction of these species have scientific evidence. This necessitates additional research to establish the effectiveness, safety and potentially develop novel therapeutics for the management of DM.

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Ethnobotanical uses, phytochemistry and bioactivities of Cymbopogon plants: A review

Zhao,

Fan,

Cheng

et al. 2024

Journal of Ethnopharmacology

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Pharmacological reflection of plants traditionally used to manage diabetes mellitus in Tanzania

Cited by 7 publications

References 108 publications

Ethnomedicine and ethnopharmacology of medicinal plants used in the treatment of diabetes mellitus in Uganda

Ethnomedicine and ethnopharmacology of medicinal plants used in the treatment of diabetes mellitus in Uganda

Ethnobotany, pharmacology and phytochemistry of medicinal plants used for management of Diabetes mellitus in Uganda, Kenya, Tanzania and the Democratic Republic of Congo

Ethnobotanical uses, phytochemistry and bioactivities of Cymbopogon plants: A review

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