Pharmacological Prospects of Morin Conjugated Selenium Nanoparticles—Evaluation of Antimicrobial, Antioxidant, Thrombolytic, and Anticancer Activities

Nirmala, C.; Sridevi, M.; Aishwarya, A.; Perara, Richard; Sathiyanarayanan, Y.

doi:10.1007/s12668-023-01116-y

Cited by 6 publications

(1 citation statement)

References 62 publications

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“…Their antioxidant properties make them suitable for treating various ailments, including cancer, neurodegenerative disorders, and cardiovascular diseases [274]. Several studies have documented strong evidence that SeNPs and their conjugates with different molecules (resveratrol [275], epigallocatechin-3-gallate [276], curcumin [277], penicillamine [278], chlorogenic acid [271], morin [279], and sialic acid [280]) showed a significant reduction in free radicals or ROS, Aβ aggregation, as well as disaggregation of preformed Aβ fibrils into harmless oligomers. Due to the antioxidant and Aβ disaggregation activity of SeNPs, they can be employed in treating various neurological disorders.…”

Section: Beneficial Action Of Selenium-based Nps (Senps) and Their An...mentioning

confidence: 99%

Role of Nanoparticle-Conjugates and Nanotheranostics in Abrogating Oxidative Stress and Ameliorating Neuroinflammation

Patel,

Kevadiya,

Bajwa

et al. 2023

Antioxidants

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Oxidative stress is a deteriorating condition that arises due to an imbalance between the reactive oxygen species and the antioxidant system or defense of the body. The key reasons for the development of such conditions are malfunctioning of various cell organelles, such as mitochondria, endoplasmic reticulum, and Golgi complex, as well as physical and mental disturbances. The nervous system has a relatively high utilization of oxygen, thus making it particularly vulnerable to oxidative stress, which eventually leads to neuronal atrophy and death. This advances the development of neuroinflammation and neurodegeneration-associated disorders such as Alzheimer’s disease, Parkinson’s disease, epilepsy, dementia, and other memory disorders. It is imperative to treat such conditions as early as possible before they worsen and progress to irreversible damage. Oxidative damage can be negated by two mechanisms: improving the cellular defense system or providing exogenous antioxidants. Natural antioxidants can normally handle such oxidative stress, but they have limited efficacy. The valuable features of nanoparticles and/or nanomaterials, in combination with antioxidant features, offer innovative nanotheranostic tools as potential therapeutic modalities. Hence, this review aims to represent novel therapeutic approaches like utilizing nanoparticles with antioxidant properties and nanotheranostics as delivery systems for potential therapeutic applications in various neuroinflammation- and neurodegeneration-associated disease conditions.

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Section: Beneficial Action Of Selenium-based Nps (Senps) and Their An...mentioning

confidence: 99%

Role of Nanoparticle-Conjugates and Nanotheranostics in Abrogating Oxidative Stress and Ameliorating Neuroinflammation

Patel,

Kevadiya,

Bajwa

et al. 2023

Antioxidants

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Ethnomedicinal Uses, Phytochemistry, Pharmacology, and Toxicology of Ruellia tuberosa L.: A Review

Sharma,

Kumar,

Singh

et al. 2024

Chemistry & Biodiversity

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Natural Products continue to be the purest source of physiologically active molecules employed in the identification of possible lead compounds in the drug discovery process. Acanthaceae is a big plant family with around 2500 species, found primarily in subtropical and tropical regions, as well as the Mediterranean, Australia, and the United States. Several species of the Acanthaceae family have been used traditionally to treat a variety of diseases, including gastrointestinal and cardiovascular ailments, etc. Ruellia tuberosa commonly known as “Mexican Bluebell” is a perennial herb that originated in Central America and has spread to some countries in the Southern tropics and Southeast Asia. It has been utilized as a traditional Rasayana plant from ancient times. R. tuberosa extracts and phytochemicals showed potent bioactivities, such as anticancer, anti‐inflammatory, wound healing, antifungal, antimicrobial, anti‐diabetic, hypoglycemic, hypolipidemic, gastro‐protective, and anthelminthic activities. Chemical analyses have unveiled a range of bioactive constituents within the plant, including alkaloids, flavonoids, saponins, and phenolic compounds, suggestive of its therapeutic potential. Collectively, this review provides an overview of R. tuberosa, encompassing its traditional uses, ethnomedicinal importance, phytochemistry, pharmacological properties, and toxicity.

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Unveiling the Biological Potential of Mycosynthesized Selenium Nanoparticles from Endophytic Fungus Curvularia sp. LCJ413

Kathiravan,

Udayan,

Rajeshkumar

et al. 2023

BioNanoSci.

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Pharmacological Prospects of Morin Conjugated Selenium Nanoparticles—Evaluation of Antimicrobial, Antioxidant, Thrombolytic, and Anticancer Activities

Cited by 6 publications

References 62 publications

Role of Nanoparticle-Conjugates and Nanotheranostics in Abrogating Oxidative Stress and Ameliorating Neuroinflammation

Role of Nanoparticle-Conjugates and Nanotheranostics in Abrogating Oxidative Stress and Ameliorating Neuroinflammation

Ethnomedicinal Uses, Phytochemistry, Pharmacology, and Toxicology of Ruellia tuberosa L.: A Review

Unveiling the Biological Potential of Mycosynthesized Selenium Nanoparticles from Endophytic Fungus Curvularia sp. LCJ413

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