Pharmacological prospection in-vitro of Lamiaceae species against human pathogenic fungi associated to invasive infections

Phytochemical characterization and biological activities of Plectranthus barbatus Andrews

“…In accordance with these results, Kapewangolo et al (2013) evaluated the influence of ethyl acetate fraction of P. barbatus leaves on secretion inhibition of proinflammatory cytokines by PBMCs and verified that this extract significatively inhibited the secretion of IL-2, IL-6, IL-10, TNF and IL-17A at 25 and 50 µg.mL -1 . Matu and Van Staden (2003) performed an anti-inflammatory activity test of the aqueous, hexanic and methanolic extracts of P. barbatus leaves at 500 μg.L -1 in a COX-1 inhibition assay and found a percentage of methanolic extract inhibition (88 ± 3.5%) higher than the aqueous extract (7.0 ± 1.5%).…”

“…Other microorganisms, as E. coli and S. aureus that causes these infections were objects of study regarding the discovery of new therapeutic options. Matu and Van Staden (2003) used the aqueous, hexanic and methanolic extracts of P. barbatus leaves to identify their actions against gram-positive bacteria (Bacillus subtilis, Micrococcus luteus, Staphylococcus aureus) and gram-negative (E. coli and K. pneumoniae) bacteria. At their study it was identified antimicrobial, antineoplastic and immunomodulatory potential of these extracts.…”

“…The study about antifungal activity of P. barbatus is scarce, however Runyoro et al (2006) studied the root extract of this plant against Candida albicans and it was effective on in vitro treatment of this microorganism. Araújo et al (2019) identified the antifungal activity of ethanol extract of P. barbatus leaves against species involved in invasive fungal disease and showed the greatest MIC values against Candida glabrata (31.2 µg.mL -1 ), Saccharomyces cerevisiae, Rhodotorula mucilaginosa, Candida krusei, Candida parapsilosis and Candida gattii (all with MIC = 62.5 µg.mL -1 ), that the methanolic extract showed activity against all Gram-positive isolates. However, Santos Veríssimo et al (2014) identified the antibacterial activity of the crude ethanol extract of P. barbatus leaves against E. coli showing a MIC = 6250 µg.mL -1 and also against Staphylococcus aureus (MIC = 3120 µg.mL -1 ).…”

Melissa officinalis: Composition, Pharmacological Effects and Derived Release Systems—A Review

“…Some of the pharmacological activities may be connected with the polyphenolic compounds occurring in Melissa officinalis , which include phenolic acids and flavonoids [ 45 , 58 ]. Most studies have focused on Melissa officinalis leaf extracts, obtaining phenolic profiles correlated with antiproliferative [ 39 ], antiangiogenic [ 4 ], antiviral [ 55 , 59 ], antioxidant [ 41 , 42 ], anti-anxiety [ 45 ], antidepressant [ 45 ], anti-Alzheimer [ 53 ], neuroprotective [ 46 ], cardioprotective [ 43 ], antifungal [ 56 , 57 ] and antibacterial [ 42 ] effects. Moaca et al [ 38 ] performed a comparative study between extractions from stems and leaves in order to evaluate the antioxidant activity, the total phenolic contents, and the cytotoxic and antiproliferative effects.…”