Pharmacological properties of total flavonoids in Scutellaria baicalensis for the treatment of cardiovascular diseases

Tan, Yuqing; Lin, Fei; Ding, Yu-Kun; Dai, Shuang; Liang, Y. X.; Zhang, Yunshu; Li, Jun; Chen, Heng-Wen

doi:10.1016/j.phymed.2022.154458

Cited by 18 publications

(7 citation statements)

References 93 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Flavonoids are a class of polyphenolic compounds with 2-phenyl flavone structure, and are generally referred to as a general term for a class of compounds with a C6-C3-C6 structure consisting of two benzene rings interconnected by three carbon atoms ( Kato et al, 2023 ; Li et al, 2022a ; Lu et al, 2022 ; Müller et al, 2022 ; Tan et al, 2022 ). They are widely present in citrus, grapes, tea, chamomile, cocoa ( Schijlen et al, 2004 ).…”

Section: Introductionmentioning

confidence: 99%

Characterization of tangeretin as an activator of nuclear factor erythroid 2-related factor 2/antioxidant response element pathway in HEK293T cells

Liang

et al. 2023

Current Research in Food Science

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Characterization of tangeretin as an activator of nuclear factor erythroid 2-related factor 2/antioxidant response element pathway in HEK293T cells

Liang

et al. 2023

Current Research in Food Science

View full text Add to dashboard Cite

“…nepeta, which is native to southern India. Less calamint is frequently used as a garnish on salads and soups [59,60,61]. Because of its relaxing effects, lesser calamint can be used as an emollient, a natural cure for toothaches, diarrhea, and other conditions [59,63,62].…”

Section: Clinopodium Nepeta Lmentioning

confidence: 99%

Plants Alkaloids Based Compound as Therapeutic Potential for Neurodegenerative

Patel¹,

Gangwar²,

Gupta³

et al. 2023

J. Res. Appl. Sci. Biotechnol.

View full text Add to dashboard Cite

Although while getting a restful night's sleep is essential for your mental and physical health, insomnia is very prevalent. More people are turning to complementary and alternative therapies to treat or prevent sleeplessness. For hundreds of years, herbal treatments like valerian, passionflower, lemon balm, lavender, and California poppy have been utilized successfully. After using these herbal medicines, sleep latency was reduced and subjective and objective measures of sleep quality improved. Their sedative and sleep-inducing effects are caused by interactions with several neurotransmitter systems in the brain, according to molecular research. The plant species can be divided into 76 different genera and 32 different families, with the Asteraceae (24.2%) and Lamiaceae (21.1%) being the most prevalent subgroups. Leaves (29%) and flowers (27%), respectively, are used to make the majority of infusions (70%) and decoctions (25%). Just the most well-known taxa—out of the 106 known—are treated here (A. arvensis L., C. nepeta L., C. monogyna Jacq., H. lupulus L., L. nobilis L., L. angustifolia Mill., M. sylvestris L., M. chamomilla L., M. officinalis L., O. basilicum L., P. rhoeas L., P. somniferum L., R. officinalis L., T. platyphyllus Scop., and V. officinalis L.). Further study is required to confirm the therapeutic potential of these substitutes and define the mechanism of action of bioactive compounds because only seven of the fifteen species chosen have been investigated for pharmacological activity as hypnotic-sedatives.

show abstract

“…Therefore, ethnobotanists have used a range of phylogenetic methods for bioprospecting 51 . According to previous research, the main pharmaceutical active ingredients of S. baicalensis are flavonoids, glycosides and aglycones 52,53 . Modern pharmacological studies show that the active ingredients of S. baicalensis have anti-bacterial, anti-tumor, anti-oxidation, anti-viral, and antiinflammation properties [6][7][8] .…”

Section: Inverted Repeats Contraction and Expansionmentioning

confidence: 99%

Identification of three cultivated varieties of Scutellaria baicalensis using the complete chloroplast genome as a super-barcode

Jiang

Zhu

Wang

et al. 2023

Sci Rep

View full text Add to dashboard Cite

Scutellaria baicalensis has been one of the most commonly used traditional Chinese medicinal plants in China for more than 2000 years. The three new varieties cultivated could not be distinguished by morphology before flowering. It will hinder the promotion of later varieties. Chloroplast DNA has been widely used in species identification. Moreover, previous studies have shown that complete chloroplast genome sequences have been suggested as super barcodes for identifying plants. Therefore, we sequenced and annotated the complete chloroplast genomes of three cultivated varieties. The chloroplast genomes of SBW, SBR, and SBP were 151,702 bp, 151,799 bp, and 151,876 bp, which contained 85 protein-coding genes, 36 tRNA genes, and 8 rRNA genes. The analysis of the repeat sequences, codon usage, and comparison of chloroplast genomes shared a high degree of conservation. However, the sliding window results show significant differences among the three cultivated varieties in matK-rps16 and petA-psbJ. And we found that the matK-rps16 sequence can be used as a barcode for the identification of three varieties. In addition, the complete chloroplast genome contains more variations and can be used as a super-barcode to identify these three cultivated varieties. Based on the protein-coding genes, the phylogenetic tree demonstrated that SBP was more closely related to SBW, in the three cultivated varieties. Interestingly, we found that S. baicalensis and S. rehderiana are closely related, which provides new ideas for the development of S. baicalensis. The divergence time analysis showed that the three cultivated varieties diverged at about 0.10 Mya. Overall, this study showed that the complete chloroplast genome could be used as a super-barcode to identify three cultivated varieties of S. baicalensis and provide biological information, and it also contributes to bioprospecting.

show abstract

Pharmacological properties of total flavonoids in Scutellaria baicalensis for the treatment of cardiovascular diseases

Cited by 18 publications

References 93 publications

Characterization of tangeretin as an activator of nuclear factor erythroid 2-related factor 2/antioxidant response element pathway in HEK293T cells

Characterization of tangeretin as an activator of nuclear factor erythroid 2-related factor 2/antioxidant response element pathway in HEK293T cells

Plants Alkaloids Based Compound as Therapeutic Potential for Neurodegenerative

Identification of three cultivated varieties of Scutellaria baicalensis using the complete chloroplast genome as a super-barcode

Contact Info

Product

Resources

About