2012
DOI: 10.1111/j.1476-5381.2012.01942.x
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Pharmacological properties of S1RA, a new sigma‐1 receptor antagonist that inhibits neuropathic pain and activity‐induced spinal sensitization

Abstract: These findings contribute to evidence identifying the σ(1) receptor as a modulator of activity-induced spinal sensitization and pain hypersensitivity, and suggest σ(1) receptor antagonists as potential novel treatments for neuropathic pain.

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Cited by 161 publications
(229 citation statements)
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References 37 publications
(65 reference statements)
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“…These antinociceptive effects are in good agreement with previous data related to the effect of σ1R antagonists in different animal models such as the sciatic nerve ligation (de la Puente et al., 2009; Romero et al., 2012) or the paclitaxel‐induced neuropathy (Nieto et al., 2012). …”
Section: Discussionmentioning
confidence: 99%
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“…These antinociceptive effects are in good agreement with previous data related to the effect of σ1R antagonists in different animal models such as the sciatic nerve ligation (de la Puente et al., 2009; Romero et al., 2012) or the paclitaxel‐induced neuropathy (Nieto et al., 2012). …”
Section: Discussionmentioning
confidence: 99%
“…To disregard acute effects of the last dose, behavioural tests were carried out 12 h after the last administration (week 15) because E‐52862 maximum plasma concentration is achieved shortly after its administration to rodents ( t max  = 15 min after i.p. administration to rats) and it is quickly metabolized, having a short half‐life in rats ( t 1/2  = 1.4 h) (Romero et al., 2012; Vidal‐Torres et al., 2014). …”
Section: Methodsmentioning
confidence: 99%
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