Pharmacological properties and phytoconstituents of garlic (Allium sativum L.): A review

Choudhary, Sunvej; Noor, Mohd Ubed; Hussain, Md Sadique

doi:10.55006/biolsciences.2022.2402

Cited by 4 publications

(4 citation statements)

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“…Allicin, an organosulfur, is considered responsible for many of the biological effects of garlic. Garlic also contains sulfur-containing compounds, such as DADS (diallyl disulfide), DATS (diallyl trisulfide), and alliin; various enzymes such as alliinase; vitamins A, C, and B-complex; amino acids, such as histidine, arginine, cysteine, methionine, and phenylalanine; flavonoids; and high amounts of potassium, zinc, sulfur, and selenium [16]. The therapeutic effect of garlic in alopecia areata is related to its anti-inflammatory, immunomodulatory, and antioxidant activities.…”

Section: Discussionmentioning

confidence: 99%

Garlic Exosomes Promote Hair Growth Through the Wnt/β-catenin Pathway and Growth Factors

Inan Yuksel,

Cicek,

Demir

et al. 2023

Cureus

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BackgroundExosomes are membrane-derived nanovesicles produced by cells and play an important role in intercellular communication. ObjectivesThis study aimed to investigate the effects of garlic exosome (GE) on hair growth. MethodsForty-two Sprague-Dawley/Wistar albino rats were randomly divided into six groups: non-shaved control, shaved control, topical control, GE 2 mg, GE 4 mg, and topical GE. At the end of the experiment, the number of hair follicles, follicle diameter, and subcutaneous tissue thicknesses were measured histopathologically. The Wnt-1, β-catenin, platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), transforming growth factor-β1 (TGF-β1), and collagen I levels were measured by the Western Blot method. ResultsThe anagen follicle counts of the GE 2 mg, 4 mg, and topical GE groups were 66.57±15.49, 105.71±25.06, and 55.29±6.72, and were significantly higher than the control groups (p<0.01, p<0.001 and p<0.05, respectively). The follicle diameter of the GE 4 mg group was higher than the others (p<0.05). The Wnt-1, PDGF, VEGF, TGF-β1, and collagen I levels of all GE groups, and the β-catenin levels of the GE 4 mg and topical GE groups were significantly higher than the control groups (p<0.05). ConclusionGE induces hair growth in rats via the Wnt-1, β-catenin, VEGF, PDGF, and TGF-β1 signaling pathways.

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Section: Discussionmentioning

confidence: 99%

Garlic Exosomes Promote Hair Growth Through the Wnt/β-catenin Pathway and Growth Factors

Inan Yuksel,

Cicek,

Demir

et al. 2023

Cureus

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“…The wound closure was assessed using macroscopic parameters (measurements) at steady intervals of time, days 3, 6, 9, 12, and 15 after the sterile incision was created, and calculated as per hundred of wound closure and the establishment of fresh epithelial tissue indicates epithelization time. The period of epithelization is the number of days necessary for dropping the scar without any remaining fresh wound (Kokane et al, 2009) and this was calculated in line with the method previously used by Bazafkan et al (2014).…”

Section: Experimental Techniquementioning

confidence: 99%

Analyzing the Ability of Various Chosen Medicinal Herbs to Cure Wounds in African Catfish (Clarias gariepinus, Burchell 1822)

Tiamiyu,

Bolaji-Alabi,

Okocha

et al. 2023

JAFH

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Phytomedicines are affordable, safe, and offer great potential for treating and controlling wounds. The effects of herbal supplements on Clarias gariepinus wound healing was investigated. Twenty-four fish (146.4±0.74g) randomised into four paired sub-groups: G1 and G2, G3 and G4, G5 and G6, G7, and G8 were fed formulated rations containing no herbal additive (0.0g/kg), 5.0g/kg of Allium sativum, 10.0g/kg of Chromolaena odorata and 10.0g/kg of Talinum triangulare as feed additive respectively at 5% body weight. On the 21st day, a sterile incision measuring 45.0 mm by 1.0 mm was made on the dorsolateral side of each fish. Subgroups G2, G4, G6, and G8 were intraperitoneally inoculated with 0.1 ml of pathogenic Pseudomonas aeruginosa that had been predetermined (1.4 x106 bacteria/ml), while G1, G3, G5, and G7 were not inoculated. Post-incision, macroscopic parameters (measurements), given as percentage healing rates on days 3, 6, 9, 12, and 15, were used to evaluate the wound closure. Data were analyzed using descriptive statistics and ANOVA at α0.05. On day 3, there were significant differences between the control and treatment groups in the healing pattern (P < 0.05). On day 15 post-incision, G7 had the best healing rate in both inoculated (86.7 percent) and uninoculated (100 percent) fish, while G1 had the lowest healing rate (0.0 percent) and maximum healing rate (64.4 percent), respectively. The findings indicated that Talinum triangulare at a concentration of 10.0 g/kg was the optimum feed additive for promoting wound healing in Clarias gariepinus.

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“…Garlic Properties: Garlic is known to have multiple medicinal properties which includes immune functions, antifungal, antibacterial, antivirus, anti-oxidant, detoxification, inhibit platelet aggregation, lowering of cholesterol and triglycerides, reduction in blood pressure, anticancer effects, prevention of arteriosclerosis, and antithrombotic properties 48,49 .…”

Section: Extraction Of Garlic Essential Oilmentioning

confidence: 99%

Untitled

2023

IJPSR

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Lead comes in a category of toxic heavy metal which acts as a pollutant when present in high concentration in the environment and cause severe effects on the human body. Due to its continuous use its level increases and serves as a serious threat for the society. Lungs and skin are the first organs which get affected by Lead toxicity. Lungs are the most important and sensitive part of human therefore the toxic effects of lead toxicity on lungs cause severe damage. Garlic (Allium sativum) with medicinal properties is being used for various human ailments since ancient times. Due to its anti-cancerous, antidiabetic, antimicrobial, antioxidant activities helps in reducing the lead toxicity in the lungs as well. Garlic is rich in many components such as sulphur compounds, amino acids, vitamins, protein, trace elements thereby making it a potent therapeutic agent. Since, the therapeutic properties of garlic has not been considered up to its best possible level against heavy metal toxicity therefore, this article presents the toxicity of Lead on lungs and medicinal properties of Garlic. INTRODUCTION:The environment is made up of three elements: land, atmosphere, and water, into which humans, plants and microbes resides. There are several layers in the environment which include biosphere-refers to living things, atmosphere refers to the air, lithosphere refers to land, and hydrosphere refers to water, that function together in harmony 1, 2, 3, 4 . Pollutants like inorganic ions, organometallic compounds, heavy metals, radioactive isotopes, gaseous pollutants, and nanoparticles have significantly damaged the environment.

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Pharmacological properties and phytoconstituents of garlic (Allium sativum L.): A review

Cited by 4 publications

References 0 publications

Garlic Exosomes Promote Hair Growth Through the Wnt/β-catenin Pathway and Growth Factors

Garlic Exosomes Promote Hair Growth Through the Wnt/β-catenin Pathway and Growth Factors

Analyzing the Ability of Various Chosen Medicinal Herbs to Cure Wounds in African Catfish (Clarias gariepinus, Burchell 1822)

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