Abstract:MEN 11066 is a new non-steroidal compound which potently inhibits human placenta (K i = 0.5 nM) and rat ovarian (K i = 0.2 nM) aromatase in vitro. In vivo, a single oral dose of 0.3 mg kg −1 significantly decreased uterus weight in immature rats after stimulation of uterus growth by androstenedione. MEN 11066 reduced in a dose-dependent manner plasma estradiol levels in adult female rats treated with pregnant mare serum gonadotropin (PMSG). After 2 weeks of repeated daily treatment in adult rats, a significant… Show more
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