Pharmacological Profile of Garcinielliptone FC from Platonia insignis

Total synthesis and structural reassignment of garcinielliptone FC, a polycyclic polyprenylated acylphloroglucinol with diverse bioactivity

“…2 To date, the structure of GFC has been widely cited and its biological activity has been extensively studied. 1–22 It displays diverse biological activities such as anticancer, 4,5,11 antioxidant, 1–3 vasorelaxant, 6 anticonvulsive, 7 and antiparasitic 5,17 properties. Further study on its antitumor mechanism revealed that it caused DNA damage and mutagenicity and induced autophagy.…”

“…9 Also, a recent review specifically summarized the pharmacological profile of GFC in detail. 21 Structurally, GFC (1), bearing a bicyclo[3.3.1]nonane-2,4,9trione core, was assigned to be a type A polycyclic polyprenylated acylphloroglucinol (PPAP) because of the acyl group located at the C-1 position (Fig. 1).…”