Pharmacological profile of dexketoprofen in orofacial pain

Miranda, Hugo F.; Sierralta, Fernando; Aranda, Nicolás; Noriega, Viviana; Prieto, Juan Carlos

doi:10.1016/j.pharep.2016.06.015

Cited by 10 publications

(7 citation statements)

References 24 publications

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“…In this occasion, the tests used were tonic pain (acetic acid writhing test), phasic pain (tail flick test) and inflammatory pain (orofacial formalin test). Furthermore, results obtained are in agreement with previous reported different profiles of nociceptive activity of NSAIDs in algesiometer tests [7][8][9][10][11][12].…”

Section: Discussionsupporting

confidence: 92%

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Non-steroidal Anti-inflammatory Drugs in Tonic, Phasic and Inflammatory Mouse Models

et al. 2019

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The principal mechanism of action of non-steroidal anti-inflammatory drugs (NSAIDs) is the inhibition of ciclooxigenases. In this study was evaluated if NSAIDs could induce antinociceptive differences according to the type of murine pain model. Male mice were injected intraperitoneally with meloxicam, diclofenac, piroxicam, metamizol, ibuprofen, naproxen and paracetamol in the writhing, tail flick and formalin orofacial tests and dose-response were analyzed to obtain the ED50 of each drugs. Administration of NSAIDs produced in a dose-dependent antinociception with different potency in the tests. The relative potency of NSAIDs among the tests shows a value of 5.53 in the orofacial formalin test in phase I and 6.34 in phase II between meloxicam and paracetamol; of 7.60 in the writhing test between meloxicam and paracetamol and of 8.46 in the tail flick test between ibuprofen and paracetamol. If the comparison is made for each NSAID in the different tests, the minimum value was 0.01 for between writhing and phase II of the orofacial formalin. Meanwhile, the highest power ratio was 11.71 for diclofenac between writhing and tail flick tests. In conclusion, the results suggests that intraperitoneal NSAIDs administration induce antinociceptive activity depending on the type of pain. The results support that NSAIDs administration, induce a wide variety of antinociceptive effect, depending on the type of pain. This suggest the participation of different mechanisms of action that can be added to the simple inhibition of COXs controlled by NSAIDs.

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Section: Discussionsupporting

confidence: 92%

“…Thereby, among the evidences has been included their interaction with monoaminergic, nitric oxide, endocannabinoids, serotonergic and cholinergic systems and endogenous opioid pathway [13][14][15][16].…”

Section: Discussionmentioning

confidence: 99%

Non-steroidal Anti-inflammatory Drugs in Tonic, Phasic and Inflammatory Mouse Models

et al. 2019

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“…The results of our experimental assay showed that dexketoprofen induces a dose‐dependent antinociceptive activity in the acetic acid‐induced abdominal contortions test in mice. Dexketoprofen produced similar antinociceptive activity to that previously reported in the writhing test in mice [22,23], as well as in other animal pain models [24–26]. The antinociceptive potency of the individual drugs was performed by comparing the ED 50 of our study with that of previous reports.…”

Section: Discussionsupporting

confidence: 76%

Antinociception and less gastric injury with the dexketoprofen‐tapentadol combination in mice

la-Torre

Alonso-Castro

Zapata-Morales

et al. 2020

Fundamemntal Clinical Pharma

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The purpose of this study was to evaluate the antinociceptive interaction between dexketoprofen and tapentadol in three different dose ratios, as well as the ulcerogenic activity of this combination. Dose–response curves were carried out for dexketoprofen, tapentadol, and dexketoprofen–tapentadol combinations in the acetic acid‐induced writhing test in mice. On the other hand, the gastric damage of all treatments was assessed after the surgical extraction of the stomachs. Intraperitoneal administration of dexketoprofen and tapentadol induced a dose‐dependent antinociceptive effect, reaching a maximal effect of about 58% and 99%, respectively. Isobolographic analysis and the interaction index showed that the three proportions produced an analgesic potentiation (synergistic interaction). Interestingly, the 1:1 and 1:3 ratios of the drugs combination produced minor gastric injury in comparison with the 3:1 proportion. Our data suggest that all proportions of the dexketoprofen–tapentadol combination produced a synergistic interaction in the acetic acid‐induced visceral pain model in mice with a low incidence of gastric injury.

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“…Since the synthesis of optically active drugs is costly, the production and sale of racemic mixtures has been approved. However, preparations containing drugs as ( S )-isomers are also available, e.g., dexibuprofen and dexketoprofen 6,7 .…”

Section: Introductionmentioning

confidence: 99%

Syntheses and cytotoxicity of phosphatidylcholines containing ibuprofen or naproxen moieties

Kłobucki

Urbaniak

Grudniewska

et al. 2019

Sci Rep

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In this study, novel phosphatidylcholines containing ibuprofen or naproxen moieties were synthesized in good yields and high purities. Under the given synthesis conditions, the attached drug moieties racemized, which resulted in the formation of phospholipid diastereomers. The comperative studies of the cytotoxicity of ibuprofen, naproxen and their phosphatidylcholine derivatives against human promyelocytic leukemia HL-60, human colon carcinoma Caco-2, and porcine epithelial intestinal IPEC-J2 cells were carried out. The results of these studies indicated that phospholipids with NSAIDs at both sn-1 and sn-2 positions (15 and 16) were more toxic than ibuprofen or naproxen themselves, whereas 2-lysophosphatidylcholines (7 and 8) were less toxic against all tested cell lines. Phospholipids with NSAIDs at sn-1 and palmitic acid at sn-2 (9 and 10) were also less toxic against Caco-2 and normal cells (IPEC-J2).

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Pharmacological profile of dexketoprofen in orofacial pain

Abstract: The findings of this study demonstrate activation of NO and 5-HTpathways play important roles in the systemic antinociceptive effect of DEX in a murine model of inflammatory pain.

Cited by 10 publications

References 24 publications

Non-steroidal Anti-inflammatory Drugs in Tonic, Phasic and Inflammatory Mouse Models

Non-steroidal Anti-inflammatory Drugs in Tonic, Phasic and Inflammatory Mouse Models

Antinociception and less gastric injury with the dexketoprofen‐tapentadol combination in mice

Syntheses and cytotoxicity of phosphatidylcholines containing ibuprofen or naproxen moieties

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