Pharmacological Potential of Avicennia alba Leaf Extract: An Experimental Analysis Focusing on Antidiabetic, Anti-inflammatory, Analgesic, and Antidiarrheal Activity

Mitra, Saikat; Islam, Fahadul; Das, Rajib; Urmee, Humaira; Akter, Aklima; Idris, Abubakr M.; Khandaker, Mayeen Uddin; Almikhlafi, Mohannad A.; Sharma, Rohit; Emran, Talha Bin

doi:10.1155/2022/7624189

Cited by 22 publications

(22 citation statements)

References 50 publications

(50 reference statements)

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“…Many researchers are working on herbal medicine to prove its effectiveness in a variety of diseases including COVID-19 [5][6][7][8][9][10][11][12][13][14]. It is well documented that herbal medicine has proven its role in the treatment of inflammation, obesity, cancer, diabetes mellitus, etc.…”

Section: Introductionmentioning

confidence: 99%

Unani Formulation Habb-e-Suranjan: A Treasure of Biological Activities

Tu¹,

Aejazuddin²,

Khan³

et al. 2022

BioMed Research International

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Habb-e-Suranjan (HES), an Unani formulation, has been studied for its anti-inflammatory properties in both in vitro and in vivo experiments. HES is recommended for arthritis, gout, and joint pain. The current endeavor is an attempt to put it to the test and verify its efficacy scientifically. It was tested for DPPH, hydroxyl, and nitric oxide scavenging activities. It was shown that HES had the greatest TAC and FRAC values when compared to catechin and ascorbic acid. HES exhibited DPPH and hydroxyl radical scavenging activity that was dose-dependent. Incubation of sodium nitroprusside solutions in PBS at 25°C for 150 min resulted in the production of nitric oxide. Nitric oxide production was effectively decreased by HES. Anti-inflammatory medications boosted the migration of PMN cells toward the chemoattractant FMLP in an agarose experiment of PMN chemotaxis. In carrageenan-induced rat paw edema, in the HES-treated group, paw thickness was 3.021 ± 0.084 at t = 0 , but it showed an increase in paw inflammation after one hour, i.e., 3.195 ± 0.082 cm which again showed a decrease in paw thickness up to 4th hour, i.e., 3.018 ± 0.078 , 2.98 ± 0.032 , and 2.684 ± 0.061 at t = 2 , 3, and 4, respectively. It showed again getting back to the normal thickness of paw at t = 24 hrs, i.e., 3.029 ± 0.118 cm. It is concluded that the formulation is potent enough and can be used effectively for the treatment of inflammation and associated health issues. Moreover, there is much scope to evaluate its effectiveness using different in vitro and in vivo models.

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Section: Introductionmentioning

confidence: 99%

Unani Formulation Habb-e-Suranjan: A Treasure of Biological Activities

Tu¹,

Aejazuddin²,

Khan³

et al. 2022

BioMed Research International

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“…Curcumin improved glucose/lipid metabolic imbalance and increased insulin resistance in diabetic rats, according to a study [ 61 ]. The results could be linked to a decrease in TNF- α and free fatty acid in serum [ 4 ]. Curcumin has antidiabetic properties in both T1DM and T2DM patients.…”

Section: Polyphenolic Compounds and Their Properties Against T1dm And...mentioning

confidence: 99%

“…If left untreated or improperly managed, it can lead to a plethora of complications [ 2 , 3 ]. While hyperosmolar hyperglycemia, diabetic ketoacidosis, and even mortality are common acute complications of DM, severe chronic problems include cognitive impairment, retinal damage, nerve damage, foot ulcers, and chronic kidney disease [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Investigating Polyphenol Nanoformulations for Therapeutic Targets against Diabetes Mellitus

Islam

Khadija

Islam

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Diabetes mellitus (DM) is a fatal metabolic disorder, and its prevalence has escalated in recent decades to a greater extent. Since the incidence and severity of the disease are constantly increasing, plenty of therapeutic approaches are being considered as a promising solution. Many dietary polyphenols have been reported to be effective against diabetes along with its accompanying vascular consequences by targeting multiple therapeutic targets. Additionally, the biocompatibility of these polyphenols raises questions about their use as pharmacological mediators. Nevertheless, the pharmacokinetic and biopharmaceutical properties of these polyphenols limit their clinical benefit as therapeutics. Pharmaceutical industries have attempted to improve compliance and therapeutic effects. However, nanotechnological approaches to overcome the pharmacokinetic and biopharmaceutical barriers associated with polyphenols as antidiabetic medications have been shown to be effective to improve clinical compliance and efficacy. Therefore, this review highlighted a comprehensive and up-to-date assessment of polyphenol nanoformulations in the treatment of diabetes and vascular consequences.

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“…The main hydroxycinnamic acids were caffeic, ferulic, sinapic, and p -coumaric acids. Emphasizing that the cauliflower and cabbage presented high contents of flavonoids (5.70 mg/g dry weight) and hydroxycinnamic acids (46.02 mg/g of dry weight) ( 48 , 56 , 57 ).…”

Section: Functional Bioactive Compounds From Cruciferous Vegetablesmentioning

confidence: 99%

Cruciferous vegetables as a treasure of functional foods bioactive compounds: Targeting p53 family in gastrointestinal tract and associated cancers

et al. 2022

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In the past few years, phytochemicals from natural products have gotten the boundless praise in treating cancer. The promising role of cruciferous vegetables and active components contained in these vegetables, such as isothiocyanates, indole-3-carbinol, and isothiocyanates, has been widely researched in experimental in vitro and in vivo carcinogenesis models. The chemopreventive agents produced from the cruciferous vegetables were recurrently proven to affect carcinogenesis throughout the onset and developmental phases of cancer formation. Likewise, findings from clinical investigations and epidemiological research supported this statement. The anticancer activities of these functional foods bioactive compounds are closely related to their ability to upregulate p53 and its related target genes, e.g., p21. As the “guardian of the genome,” the p53 family (p53, p63, and p73) plays a pivotal role in preventing the cancer progression associated with DNA damage. This review discusses the functional foods bioactive compounds derived from several cruciferous vegetables and their use in altering the tumor-suppressive effect of p53 proteins. The association between the mutation of p53 and the incidence of gastrointestinal malignancies (gastric, small intestine, colon, liver, and pancreatic cancers) is also discussed. This review contains crucial information about the use of cruciferous vegetables in the treatment of gastrointestinal tract malignancies.

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Pharmacological Potential of Avicennia alba Leaf Extract: An Experimental Analysis Focusing on Antidiabetic, Anti-inflammatory, Analgesic, and Antidiarrheal Activity

Cited by 22 publications

References 50 publications

Unani Formulation Habb-e-Suranjan: A Treasure of Biological Activities

Unani Formulation Habb-e-Suranjan: A Treasure of Biological Activities

Investigating Polyphenol Nanoformulations for Therapeutic Targets against Diabetes Mellitus

Cruciferous vegetables as a treasure of functional foods bioactive compounds: Targeting p53 family in gastrointestinal tract and associated cancers

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