Pharmacological potential of alkylamides from Acmella oleracea flowers and synthetic isobutylalkyl amide to treat inflammatory pain

Dallazen, Jorge Luiz; Maria-Ferreira, Daniele; Luz, Bruna Barbosa da; Nascimento, Adamara Machado; Cipriani, Thales R.; Souza, Lauro Mera de; Felipe, Letícia Polli Glugoski; Silva, Bruno José Gonçalves; Nassini, Romina; Werner, Maria Fernanda de Paula

doi:10.1007/s10787-019-00601-9

Cited by 24 publications

(15 citation statements)

References 53 publications

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“…When the leaves and flowers are chewed, they cause a tingling sensation to tongue and lips due to the presence of alkylamides, the most abundant in A. oleracea being spilanthol. This isobutylamide derivative presents local anesthetic action and this effect justifies the traditional use for treating toothache [ 1 , 2 , 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

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Comparison of Biostimulant Treatments in Acmella oleracea Cultivation for Alkylamides Production

Sut

Ferrarese

Shrestha

et al. 2020

Plants

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Acmella oleracea is a promising cosmetic, nutraceutical, and pharmaceutical ingredient, and plants with high levels of active compounds are needed in the market. Cultivation can be valuable if sufficient levels of alkylamides are present in plant material. In this regard the application of biostimulants can be an innovative approach to increase yield of cultivation or bioactive compound levels. A. oleracea plants were cultivated in Northern Italy in an experimental site using three different types of biostimulants, triacontanol-based mixture (Tria), an extract from plant tissues (LL017), and seaweed extract (Swe). Plants were grown in the field in two different growing seasons (2018 and 2019). After treatments inflorescences were harvested and the quali-quantitative analysis of alkylamides and polyphenols was performed. Treated and control plants were compared for yields, morphometric measurements, quali-quantitative composition in secondary metabolites. Overall results show that both triacontanol-based mixture and the LL017 positively influenced plant growth (Tria >+ 22%; LL017 >+ 25%) and flower production (Tria >+ 34%; LL017 >+ 56%). The amount of alkylamides and polyphenols in flowers were between 2.0–5.2% and 0.03–0.50%, respectively. Biostimulant treatments ensure higher cultivation yields and allow maintenance of the alkylamide and polyphenol levels based on % (w/w), thus offering an advantage in the final quantity of extractable chemicals. Furthermore, data revealed that samples harvested in late season show a decrease of polyphenols.

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Section: Introductionmentioning

confidence: 99%

“…Jambu is attracting greater interest in the field of herbal medicine and nutraceuticals due to its potential analgesic, antioxidant, and anti-inflammatory activities, and several patent applications have been filed, showing the industrial potential of this plant for cosmetic and pharmaceutical applications [ 2 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Comparison of Biostimulant Treatments in Acmella oleracea Cultivation for Alkylamides Production

Sut

Ferrarese

Shrestha

et al. 2020

Plants

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“…or vehicle (V: sterile 0.9% saline, 80 µL, i.pl.) [31]. Two hours later, POE extract was suspended in 1% carboxymethylcellulose sodium salt (CMC) and orally administered.…”

Section: Carrageenan-induced Pain and Paw Oedema In Micementioning

confidence: 99%

Efficacy of Posidonia oceanica Extract against Inflammatory Pain: In Vivo Studies in Mice

et al. 2021

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Posidonia oceanica (L.) Delile is traditionally used for its beneficial properties. Recently, promising antioxidant and anti-inflammatory biological properties emerged through studying the in vitro activity of the ethanolic leaves extract (POE). The present study aims to investigate the anti-inflammatory and analgesic role of POE in mice. Inflammatory pain was modeled in CD-1 mice by the intraplantar injection of carrageenan, interleukin IL-1β and formalin. Pain threshold was measured by von Frey and paw pressure tests. Nociceptive pain was studied by the hot-plate test. POE (10–100 mg kg−1) was administered per os. The paw soft tissue of carrageenan-treated animals was analyzed to measure anti-inflammatory and antioxidant effects. POE exerted a dose-dependent, acute anti-inflammatory effect able to counteract carrageenan-induced pain and paw oedema. Similar anti-hyperalgesic and anti-allodynic results were obtained when inflammation was induced by IL-1β. In the formalin test, the pre-treatment with POE significantly reduced the nocifensive behavior. Moreover, POE was able to evoke an analgesic effect in naïve animals. Ex vivo, POE reduced the myeloperoxidase activity as well as TNF-α and IL-1β levels; further antioxidant properties were highlighted as a reduction in NO concentration. POE is the candidate for a new valid strategy against inflammation and pain.

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“…These renewable sources have useful qualities to industries for the production of food, chemicals, pharmacological agents, and cosmetics. In the northern region of Brazil, an unconventional vegetable from the Asteraceae family, jambu [ Acmella oleracea (L.) R.K Jansen], particularly stands out as a species with valuable attributes that could be harnessed for commercial use (Dallazen et al., 2019; Neves et al., 2019).…”

Section: Introductionmentioning

confidence: 99%

“…Spilanthol is an isobutylamide compound that promotes a local anesthetic action, possesses anti‐inflammatory and analgesic properties. Spilanthol can also be used to relieve the etiological actions of several cardiovascular pathologies through relaxing the arteries, as well as against gastrointestinal diseases such as mucositis and pancreatitis, skin lesions, and dermatitis (Benelli et al., 2019; Dallazen et al., 2019; Rondanelli et al., 2020). All the health‐related properties associated with A .…”

Section: Introductionmentioning

confidence: 99%

Physicochemical properties and bioactive composition of the lyophilized Acmella oleracea powder

Santos

Soares

Vieira

et al. 2021

J. Food Process. Preserv.

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The aim of this study was to obtain and characterize a lyophilized leaf powder from Acmella oleracea (LPA) as a functional food ingredient. Sorption isotherms of LPA display a monolayer moisture content of 9.1 and 9.3 g H2O 100 g–1 for adsorption and desorption, respectively. The flavonoids, ascorbic acid, and total polyphenols content, were approximately 235 mg 100 g–1, 18 mg 100 g–1, and 2,480 mg GAE 100 g–1, respectively. The antioxidant activity by TEAC showed the greatest value, ~291 mg TE L–1, against DPPH and FRAP assays (p < .05). The FTIR spectrum revealed high intensity bands at 3,400 cm–1 related to vibrations of cellulose and organic acids. The thermo‐behavior showed an initial degradation temperature at 222°C and peak temperature of 278°C. These results indicate great potential of LPA as a natural source of bioactive compounds, which could contribute to its utilization as a functional ingredient in foods. Practical applications The lyophilized leaf powder from Acmella oleracea as a natural source of bioactive compounds could contribute to its utilization as a functional ingredient in foods.

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Pharmacological potential of alkylamides from Acmella oleracea flowers and synthetic isobutylalkyl amide to treat inflammatory pain

Cited by 24 publications

References 53 publications

Comparison of Biostimulant Treatments in Acmella oleracea Cultivation for Alkylamides Production

Comparison of Biostimulant Treatments in Acmella oleracea Cultivation for Alkylamides Production

Efficacy of Posidonia oceanica Extract against Inflammatory Pain: In Vivo Studies in Mice

Physicochemical properties and bioactive composition of the lyophilized Acmella oleracea powder

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