Pharmacological perturbation of murine melanoma growth by copper chelates

Pierson, Herbert F.

doi:10.1016/0304-3835(85)90030-8

Cited by 5 publications

(3 citation statements)

References 25 publications

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“…The growth promoting activity of exogenous copper in the B16 melanoma system involves both enhanced copper nutrition and concomitant alteration of host reactions to tumors. [21] This exception was observed in cuprous chelate of neocuproine (NC-Cu +1 ) that enhanced tumorogenicity of s.c. tumors. [21,22] But, cupric chelate of nitrilotriacetic acid (NTA-Cu 2+ ) inhibited pigmentation in s.c. tumors.…”

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Role of chelates in treatment of cancer

Tripathi¹,

Kumar²,

Singhai³

2007

Indian J Cancer

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Chelates are used in cancer as cytotoxic agent, as radioactive agent in imaging studies and in radioimmunotherapy.Various chelates based on ruthenium, copper, zinc, organocobalt, gold, platinum, palladium, cobalt, nickel and iron are reported as cytotoxic agent. Monoclonal antibodies labeled with radioactive metals such as yttrium-90, indium-111 and iodine-131 are used in radioimmunotherapy. This review is an attempt to compile the use of chelates as cytotoxic drugs and in radioimmunotherapy.

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“…[21,22] But, cupric chelate of nitrilotriacetic acid (NTA-Cu 2+ ) inhibited pigmentation in s.c. tumors. [21] Further, it was concluded that the growth-promoting activity of NC-Cu +1 on tumors is related to the oxidation state of copper in chelates and enhanced copper nutriture of tumors. [22] …”

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Role of chelates in treatment of cancer

Tripathi¹,

Kumar²,

Singhai³

2007

Indian J Cancer

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“…deficient rabbits w'ere unable to increase the angiogen ic response in the corneal test and that copper accu mulation occurred before the capillaries penetrated the cornea. Moreover, Pierson [23] suggested that exogenous copper stimulates melanoma growth.…”

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confidence: 99%

Localization of Tissue Copper in Mouse Mammary Tumors

Fuchs

Lustig²

1989

Oncology

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The purpose of this study was to determine the copper deposition and localization during the evolution of two murine mammary adenocarcinomas. In the normal tissue, the copper was located within the cytoplasm, whereas it was intra- and perinuclear in the tumors. The more angiogenic and metastatic tumor showed the higher percentage of copper-positive cells. In the tumor, copper deposits correlated well with its angiogenic and metastatic ability, but additional factors would be required for the process to be induced.

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