Pharmacological of an Intra-oral Fluoride-releasing Device in Adolescents

Abstract

The purpose of this study was to quantify fluoride (F) concentrations in body fluids of adolescents wearing two intra-oral fluoride-releasing devices (IFRDs) designed to release 0.10 mg F/day. Fluoride concentrations were determined potentiometrically. No significant increases occurred in urine or serum F concentrations during the 26-week device phase. Elevated salivary F concentrations were maintained throughout the device phase when broken or depleted IFRDs were replaced. However, salivary F concentrations returned to pre-device phase values by 26 weeks when the original IFRDs were maintained. These findings suggest that IFRDs can significantly elevate salivary F concentrations of adolescents without significant elevations in systemic F concentrations.

Salivary and Urinary Fluoride Levels after 1-Month Use of Fluoride-Releasing Removable Appliances

“…The results o f group 1, which used appliances with controlled-release reservoirs, were in agreement with the in vi vo studies of Mirth et al [1982] and Kula et al [1987]. How ever, the differences in release rates for different intra-oral fluoride devices, the fact that some subjects lived in a fluori dated area (1 ppm) as well as different measures of fluoride concentration (ppm or pg/ml) make comparison of the re sults difficult.…”

“…In this way salivary fluoride concentration will be maintained at a desired level. For this reason in vivo and in vitro investigations using fluoride-releasing tablets, aerosol-type capsules, fluoride-releasing polymers, glass devices and membrane-controlled fluoride reservoirs have gained popularity in past years [Cowsar et al, 1976;Mirth, 1987;Kula et al, 1987;Toumba and Curzon, 1993]. Chil dren undergoing orthodontic treatment are a specific group needing continuous fluoride application and so the modifi K Ä R G E R © I996 S. Karger AG, Basel IX /' " U 0008 6568/96/0303-0200 S 10.00/0 E-Mail kargeren karger.ch Tax +41 61 30612 34 cation of orthodontic appliances is one approach requiring further investigation.…”

“…All fluoride analyses were done with a fluoride ion-sensitive elec trode (Russell 96-6099) combined to a pH/mV meter (Orion 720 A) with previously described methods [Mirth et a!., 1982;Kula et al" 1987], A buffer solution (TISAB II, Orion Research) was added 1:1 to all samples. Stock fluoride solutions (Russell 949070) were prepared be tween 0.0625 and 1.000 ppm in TISAB II and electropotentials were detected.…”

Evaluation of a New Intraoral Controlled Fluoride Release Device

“…In this context Mirth et al [1982] used a HEMA/MMA copolymer membrane with a release rate of 0.5 mg/day whereas Kula et al [1987] used a controlled-release device with 0.2 mg/day release kinetics. Cain et al [1994] employed 0.232 and 0.07 mg/day release rates and Alaçam et al [1996] employed a 0.32 mg F/day release rate in their in vivo controlled-release studies and observed an increase in salivary fluoride levels.…”

“…Although the urinary fluoride concentration indicates the fluoride ingestion via dietary supplements [Warpeha and Marthaler, 1995;Marthaler et al, 1995], Mellberg and Ripa [1983] stated that urinary fluoride levels in children were lower than in adults, as most of the F is bound to the developing skeleton. However, Kula et al [1987] and Cain et al [1994] preferred to work with adolescent subjects in their controlled fluoride release studies. Taking this into account, 20 adolescent volunteers, ranging in age from 20 to 23 years, were included in our study.…”