Pharmacological modulation of the leukotriene pathway in allergic airway disease

Montuschi, Paolo; Sala, Angelo; Dahlén, Sven‐Erik; Folco, Giancarlo

doi:10.1016/j.drudis.2007.03.004

Cited by 80 publications

(108 citation statements)

References 70 publications

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“…The pathophysiological role of cysteinyl LTs in asthma is well documented (Drazen, 2003;Holgate et al, 2003;Sampson et al, 2003;Arm, 2004;Capra et al, 2007;Hallstrand and Henderson, 2010), and results ob-556 tained from localization studies are consistent with the antibronchoconstrictive and anti-inflammatory activities of CysLT 1 R antagonists (Kemp, 2003;Riccioni et al, 2004;Currie et al, 2005;Capra et al, 2006;Dahlén, 2006;Ducharme et al, 2006;Montuschi et al, 2007;del Giudice et al, 2009). However, the finding of CysLTR expression in other tissues will certainly encourage the discovery of new functions for cysteinyl LTs in other physiological and pathological conditions .…”

Section: Receptor Expression Patterns With Functional Significancesupporting

confidence: 61%

International Union of Basic and Clinical Pharmacology. LXXXIV: Leukotriene Receptor Nomenclature, Distribution, and Pathophysiological Functions

Bäck¹,

Dahlén²,

Drazen³

et al. 2011

Pharmacol Rev

129

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Section: Receptor Expression Patterns With Functional Significancesupporting

confidence: 61%

International Union of Basic and Clinical Pharmacology. LXXXIV: Leukotriene Receptor Nomenclature, Distribution, and Pathophysiological Functions

Bäck¹,

Dahlén²,

Drazen³

et al. 2011

Pharmacol Rev

129

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“…In response to exposure to allergens, patients with AR present an inflammatory IgE-mediated response characterized by a Th2-immunologic pattern with mast cells and eosinophil activation and the release of inflammatory mediators interleukin (IL)-1␤, IL-6, and tumor necrosis factor-␣ (Johansson et al, 2001). Leukotrienes and prostanoids produced by the 5-lipoxygenase and cyclooxygenase (COX)-2 pathways have po-tent proinflammatory and vascular actions that implicate them in the allergic and inflammatory reactions (Montuschi et al, 2007). Eosinophils are innate effector cells that are important in immune responses against helminth parasitic infections and contribute to the pathology associated with allergic inflammatory conditions.…”

Section: Introductionmentioning

confidence: 99%

Distinct Effects of Imperatorin on Allergic Rhinitis: Imperatorin Inhibits Caspase-1 Activity In Vivo and In Vitro

Oh¹,

Kim²,

Jeong³

2011

J Pharmacol Exp Ther

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Because imperatorin (IPT), the furanocoumarins exhibits antiinflammatory activity, we reasoned that IPT might modulate the allergic rhinitis (AR). The aim of this study was to analyze the regulation of AR by IPT. Here, we show the effect and mechanism of IPT in an ovalbumin (OVA)-induced AR model. The number of rubs after the OVA challenge in the OVA-sensitized mice was significantly higher than that in the OVA-unsensitized mice. The increased number of rubs was inhibited by the oral administration of IPT. The increased levels of IgE and histamine in the OVA-sensitized mice were reduced by IPT administration. The levels of interferon-␥ were enhanced, whereas the levels of interleukin (IL)-4 were reduced on the spleen tissue of the IPT-administered AR mice. Protein levels of IL-1␤, macrophage inflammatory protein-2, intercellular adhesion molecule-1, and cyclooxygenase-2 were reduced by IPT administration in the nasal mucosa of the OVA-sensitized mice. In the IPT-administered mice, the number of eosinophils and mast cells infiltration increased by OVA-sensitization were also decreased. In addition, IPT inhibited caspase-1 activity in the same nasal mucosa tissue. In activated human mast cells, the receptor-interacting protein 2 (RIP2), IB kinase (IKK)-␤, nuclear factor-B (NF-B)/ RelA, and caspase-1 activation were increased, but increased RIP2, IKK-␤, NF-B/RelA, and caspase-1 activation were inhibited by the treatment of IPT. In addition, IPT inhibited caspase-1 activity and IL-1␤ production in IgE-stimulated bone marrowderived mast cells. We can conclude that IPT exerts significant effects by regulating of caspase-1 activation in AR animal and in vitro models.

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“…In response to exposure to allergens, patients with AR present an inflammatory Immunoglobulin (Ig)E-mediated response characterized by a Th2 immunologic pattern with mast cells and eosinophils activation and the release of inflammatory mediators, interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α (Howarth, 2003;Johansson et al, 2001). Leukotrienes and prostanoids produced by the 5-lipoxygenase and cyclooxygenase (COX)-2 pathways have potent proinflammatory and vascular actions that implicate them in allergic and inflammatory reactions (Montuschi et al, 2007). Eosinophils are innate effector cells that are important in immune responses against helminthes parasitic infections and contribute to the pathology associated with allergic inflammatory conditions.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic effects of traditional Korean medicine, Jeechool-Whan in allergic rhinitis model

Oh¹,

Ryu²,

Cha³

et al. 2012

TANG [HUMANITAS MEDICINE]

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Jeechool-Whan (JW) is a prescription of Ponciri Fructus Immaturus and Atractylodis Rhizoma Alba and improves the functions of the stomach and the spleen. Although it is said in Korean Medicine that the spleen and the stomach are the roots of the body's resistance, the meaning of 'improving the spleen and the stomach' is very comprehensive. Moreover, there are lots of drugs that are said to improve the spleen and the stomach, and the number of prescriptions using these drugs is huge. In this study, we focused on the new effect and mechanism of the JW on the ovalbumin (OVA)-induced allergic rhinitis (AR) model. The increased number of rubs and the increased levels of IgE and histamine in the OVA-sensitized mice were inhibited by JW administration. The balance of Th1/Th2 cytokine level was regulated by JW administration. The levels inflammatory proteins were decreased by JW administration in the nasal mucosa of the OVA-sensitized mice. Eosinophils and mast cells infiltration increased by OVAsensitization was also decreased in the JW-administered mice. In addition, JW inhibited caspase-1 activity in the same nasal mucosa tissue. In activated human mast cells, JW inhibited the receptor interacting protein-2, IκB kinase-β, nuclear factor-κB/Rel A, and caspase-1 activation. In conclusion, this study will be support the clear understanding of the concept of the spleen and the stomach in traditional Korean medicine as well as for a possibility of finding a cure for this AR in traditional medical treatments.

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Pharmacological modulation of the leukotriene pathway in allergic airway disease

Cited by 80 publications

References 70 publications

International Union of Basic and Clinical Pharmacology. LXXXIV: Leukotriene Receptor Nomenclature, Distribution, and Pathophysiological Functions

International Union of Basic and Clinical Pharmacology. LXXXIV: Leukotriene Receptor Nomenclature, Distribution, and Pathophysiological Functions

Distinct Effects of Imperatorin on Allergic Rhinitis: Imperatorin Inhibits Caspase-1 Activity In Vivo and In Vitro

Therapeutic effects of traditional Korean medicine, Jeechool-Whan in allergic rhinitis model

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