2015
DOI: 10.1007/s10803-015-2619-y
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Pharmacological Modulation of GABA Function in Autism Spectrum Disorders: A Systematic Review of Human Studies

Abstract: Autism spectrum disorders are an emerging health problem worldwide, but little is known about their pathogenesis. It has been hypothesized that autism may result from an imbalance between excitatory glutamatergic and inhibitory GABAergic pathways. Commonly used medications such as valproate, acamprosate, and arbaclofen may act on the GABAergic system and be a potential treatment for people with ASD. The present systematic review aimed at evaluating the state-of-the-art of clinical trials of GABA modulators in … Show more

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Cited by 47 publications
(30 citation statements)
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“…Conversely, CBD increased GABA transmission (inhibitory system) in critical and subcortical regions of neurotypical subjects, while decreased it in the same areas of the ASD group. This confirms the hypothesis that GABA transmission could be altered in people with ASD [17,72,73]. Moreover, CBD modulated low-frequency activity, used as a measure of spontaneous regional brain activity, and functional connectivity in the brain of adults with ASD [57].…”
Section: Mechanisms Of Action: the Role Of Excitatory/inhibitory Systemsupporting
confidence: 82%
See 1 more Smart Citation
“…Conversely, CBD increased GABA transmission (inhibitory system) in critical and subcortical regions of neurotypical subjects, while decreased it in the same areas of the ASD group. This confirms the hypothesis that GABA transmission could be altered in people with ASD [17,72,73]. Moreover, CBD modulated low-frequency activity, used as a measure of spontaneous regional brain activity, and functional connectivity in the brain of adults with ASD [57].…”
Section: Mechanisms Of Action: the Role Of Excitatory/inhibitory Systemsupporting
confidence: 82%
“…Several genetic [18], perinatal [19,20], and environmental factors [21,22] seem to be involved. Research has also evidenced an imbalance in some endogenous neurotransmission systems [23], such as the serotoninergic [24], GABAergic [17,25], and endocannabinoid (eCB) system [26][27][28]. Alterations of the eCB neurotransmission system have been found in animal models of ASD [29].…”
Section: Of 17mentioning
confidence: 99%
“…Several previous studies have pointed to structural or functional abnormalities in inhibitory neurons in genetic models of cognitive dysfunction; in some cases, behavioral improvements were achieved through systemic pharmacological modulation of GABA transmission (19, 26, 34), but GABA modulation has not yet been found to be clinically effective for treating the core social interaction/communication and stereotyped behavioral symptoms of autism (35). …”
Section: Discussionmentioning
confidence: 99%
“…Finally, other GABAergic drugs such as riluzole, gaboxadol, tiagabine and vigabatrin, have been proposed as potential therapeutics in ASD–epilepsy syndromes (Lozano et al ., ). However, evidence supporting the beneficial effect of GABAergic drugs in ASD is still limited and controversial (Brondino et al ., ). GABA agonists (benzodiazepines) may be less effective in certain forms of ASD–epilepsy, such as 15q11.2 duplication (Jeste & Tuchman, ), and a paradoxical response to treatment with conventional GABAergic agonists has been reported in ASD (Bruining et al ., ).…”
Section: Therapeutic Perspectivesmentioning
confidence: 97%