Pharmacological Modulation of Behavioral and Neuronal Correlates of Repetition Priming

Thiel, Christiane M.; Henson, Richard N.; Morris, John; Friston, Karl J.; Dolan, Raymond J.

doi:10.1523/jneurosci.21-17-06846.2001

Cited by 84 publications

(64 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several studies in healthy young and older subjects suggest that fMRI can detect acute pharmacological effects on memory networks (Thiel et al 2001;Sperling et al 2002;Kukolja et al 2009). To date, only a few small fMRI studies have shown enhanced brain activation after acute or prolonged treatment with cholinesterase inhibitors in MCI and AD, although these studies were not conducted as typical double-blind, placebocontrolled trials (Rombouts et al 2002;Goekoop et al 2004;Saykin et al 2004;Shanks et al 2007;Bokde et al 2009;Venneri et al 2009).…”

Section: Utility Of Functional Mri In the Study Of Admentioning

confidence: 99%

Brain Imaging in Alzheimer Disease

Johnson

Fox²,

Sperling³

et al. 2012

Cold Spring Harbor Perspectives in Medicine

557

375

View full text Add to dashboard Cite

Section: Utility Of Functional Mri In the Study Of Admentioning

confidence: 99%

Brain Imaging in Alzheimer Disease

Johnson

Fox²,

Sperling³

et al. 2012

Cold Spring Harbor Perspectives in Medicine

557

375

View full text Add to dashboard Cite

“…Moreover, there is growing support for the hypothesis of the central role of the GABAergic system in neuronal plasticity required for repetition adaptivity (34,35). Yet the genes involved in the GABA turnover in the brain have never been systematically investigated as candidate genes for dyslexia.…”

mentioning

confidence: 99%

The first candidate gene for dyslexia: Turning the page of a new chapter of research

Grigorenko

2003

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

“…In healthy volunteers, behavioural and fMRI repetition effects are strongly attenuated with lorazepam, suggesting that GABAergic and cholinergic systems influence the neuronal plasticity necessary for repetition priming (Thiel, Henson, Morris, Friston, & Dolan, 2001). Conversely, facilitated processing of internal and external stimuli in anxiety has been linked to excessive excitability of cortical cholinergic inputs from the basal forebrain (Berntson, Sarter, & Cacioppo, 1998).…”

Section: Priming In Ocdmentioning

confidence: 99%

Electrophysiology of facilitation priming in obsessive–compulsive and panic disorders

Thomas

Gonsalvez

Johnstone

2016

Clinical Neurophysiology

View full text Add to dashboard Cite

Objective: Repeated experience with stimuli often primes faster, more efficient neuronal and behavioural responses. Exaggerated repetition priming effects have previously been reported in obsessive-compulsive disorder (OCD), however little is known of their underlying neurobiology or disorder-specificity, hence we investigated these factors. Methods: We examined event-related potentials (ERPs) and behaviour while participants with OCD, panic disorder and healthy controls (20 per group) performed a Go/NoGo task which manipulated target repetition sequences. Results: Both clinical groups showed stronger reaction time (RT) priming than HCs, which in OCD was greater in a checking, than washing, subgroup. Both clinical groups had similar RT deficits and ERP anomalies across several components, which correlated with psychopathology and RT priming. In OCD alone, N1 latency tended to increase to repeated stimuli, correlated with O-C symptoms, whereas it decreased in other groups. OCD-checkers had smaller target P2 amplitude than all other groups. Conclusions: Enhanced neural priming is not unique to OCD and may contribute to salient sensory-cognitive experiences in anxiety generally. These effects are related to symptom severity and occur to neutral stimuli and in the context of overall RT impairment, suggesting they may be clinically relevant and pervasive. The results indicate overlapping information-processing and neurobiological factors across disorders, with indications of OCD-specific trends and subgroup differences. Significance: This first electrophysiological investigation of OCD priming in OCD to include anxious controls and OCD subgroups allows for differentiation between overlapping and OCD-specific phenomena, to advance neurobiological models of OCD. The authors report no conflicts of interest. Highlights• We conducted the first electrophysiological investigation of repetition priming in obsessive-compulsive disorder (OCD) to include anxious and healthy controls and the first ERP study to consider OCD symptom subgroups.• Repetition priming was exaggerated in both OCD and panic disorder, and related to atypical ERP topography and symptom severity.• P2 amplitude to targets was significantly smaller in a non-washing/checking subgroup of OCD than all other groups. 3 AbstractObjective: Repeated experience with stimuli often primes faster, more efficient neuronal and behavioural responses. Exaggerated repetition priming effects have previously been reported in obsessive-compulsive disorder (OCD), however little is known of their underlying neurobiology or disorder-specificity, hence we investigated these factors. Methods:We examined event-related potentials (ERPs) and behaviour while participants with OCD, panic disorder and healthy controls (20 per group) performed a Go/ NoGo task which manipulated target repetition sequences. Results:Both clinical groups showed stronger reaction time (RT) priming than HCs, which in OCD was greater in a checking, than washing, subgroup. Both clinical groups had similar R...

show abstract

Pharmacological Modulation of Behavioral and Neuronal Correlates of Repetition Priming

Cited by 84 publications

References 52 publications

Brain Imaging in Alzheimer Disease

Brain Imaging in Alzheimer Disease

The first candidate gene for dyslexia: Turning the page of a new chapter of research

Electrophysiology of facilitation priming in obsessive–compulsive and panic disorders

Contact Info

Product

Resources

About