2005
DOI: 10.1093/alcalc/agh217
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Pharmacological Manipulation of Cb1 Receptor Function Alters Development of Tolerance to Alcohol

Abstract: The data support a role for the endocannabinoid (EC) system in EtOH tolerance/dependence and suggest that drugs targeted against EC system could be therapeutically useful in treating alcohol-related disorders.

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Cited by 22 publications
(17 citation statements)
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References 57 publications
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“…Thus, the behavioral results of the present work are consistent with those of studies demonstrating either chronic (Newman et al 1972;Macavoy and Marks 1975;Sprague and Craigmill 1976;Siemens and Doyle 1979;Marks and MacAvoy 1989) or rapid (Da Silva et al 2001) development of crosstolerance between ethanol and Δ 9 -tetrahydrocannabinol. However, the present results are at variance with those of previous studies in which SR did not block ethanol tolerance, suggesting, as mentioned in "Introduction", that the animal species, dose ranges and pretreatment times (Da Silva et al 2001), or the species and chronic ethanol protocol (Nowak et al 2006) may have contributed to these different results.…”
Section: Discussioncontrasting
confidence: 94%
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“…Thus, the behavioral results of the present work are consistent with those of studies demonstrating either chronic (Newman et al 1972;Macavoy and Marks 1975;Sprague and Craigmill 1976;Siemens and Doyle 1979;Marks and MacAvoy 1989) or rapid (Da Silva et al 2001) development of crosstolerance between ethanol and Δ 9 -tetrahydrocannabinol. However, the present results are at variance with those of previous studies in which SR did not block ethanol tolerance, suggesting, as mentioned in "Introduction", that the animal species, dose ranges and pretreatment times (Da Silva et al 2001), or the species and chronic ethanol protocol (Nowak et al 2006) may have contributed to these different results.…”
Section: Discussioncontrasting
confidence: 94%
“…Recently, however, studies have proposed that the endocannabinoid signaling system may play a role in the effects of ethanol and in ethanol tolerance and dependence (Basavarajappa and Hungund 2002;Basavarajappa and Hungund 2005;Nowak et al 2006;Beardsley and Thomas 2005).…”
Section: Introductionmentioning
confidence: 99%
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“…The development of tolerance to acute alcohol-induced hypothermia depends on the timing of the administration of the agonist. For example, tolerance occurs when the CB1 receptor agonist is given prior or along with alcohol treatment [58]. However, chronic blockade of CB1 receptor with SR141716A results in tolerance development to both sedative and hypothermic effects of alcohol in alcohol naïve mice without any effect in chronic alcohol exposed mice [58].…”
Section: Alcoholism and Endocannabinoid Systemmentioning
confidence: 99%
“…For example, tolerance occurs when the CB1 receptor agonist is given prior or along with alcohol treatment [58]. However, chronic blockade of CB1 receptor with SR141716A results in tolerance development to both sedative and hypothermic effects of alcohol in alcohol naïve mice without any effect in chronic alcohol exposed mice [58]. It is not clear at this time as to what the mechanisms are to explain these varying effects of the agonist and the antagonist on tolerance.…”
Section: Alcoholism and Endocannabinoid Systemmentioning
confidence: 99%