Pharmacological management of digital ulcers in systemic sclerosis - what is new?

Bifunctional Sildenafil Diazeniumdiolates Acting as Phosphodiesterase 5 Inhibitors and Nitric Oxide Donors− Towards Wound Healing

“…[4] Therefore, there is a critical need to develop more effective treatments, specifically vasoactive locally-acting medications, to improve patient outcomes and reduce healthcare costs. [5] Chronic wounds are often characterized by low levels of nitric oxide (NO) in blood vessels. [6,7] NO plays a pivotal role in ulcer healing through three main factors: i) promoting blood vessel dilation and angiogenesis; [8] ii) modulating the host's immune system and its inflammatory response; [9] and iii) leveraging its potent broad-spectrum antimicrobial properties.…”

“…Current therapeutic options for chronic wounds (e. g., local air suction, increase blood supply, oxygenation, or Maggot debridement) are time‐consuming and costly [4] . Therefore, there is a critical need to develop more effective treatments, specifically vasoactive locally‐acting medications, to improve patient outcomes and reduce healthcare costs [5] …”