Pharmacological management of atrial fibrillation in patients with heart failure with reduced ejection fraction: review of current knowledge and future directions

Grubb, Alex; Mentz, Robert J.

doi:10.1080/14779072.2020.1732210

Cited by 4 publications

(2 citation statements)

References 146 publications

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“…In our case patient's LVEF is 20%. [14] Digoxin serum levels should range between 0.8 and 2 ng/mL. It is critical to draw blood at least 6 to 8 hours after the last dose when measuring digoxin serum levels.…”

Section: Discussionmentioning

confidence: 99%

Case report on the interaction between furosemide and digoxin that caused digoxin toxicity

Patel¹,

Patel²,

Patel³

et al. 2022

J. Drug Delivery Ther.

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Toxicity from digitalis is a typical clinical issue. In this case, the interaction of digoxin and furosemide is becoming more widely recognised as a major cause of digitalis toxicity. We present an abnormal ECG that demonstrates digoxin-induced cardiotoxicity. We report a case of a Digoxin toxicity in a 79-year-old male patient admitted with complains of nausea, increase frequency of micturition, decrease appetite, increase nocturia, shortness of breathing. The patient is taking furosemide and digoxin as past medication for Heart block and Chronic kidney disease treatment. In patient, Serum digoxin level is high due to hypokalemia because of digoxin and furosemide drug interaction. The Electrocardiogram interpretation shows sinus bradycardia, ST segment depression, and T wave inversion which mainly due to digoxin toxicity. So for the management digoxin is omitted from the current treatment. The patient needs to be constantly monitored since digitalis poisoning is deadly. A digoxin-binding antibody is the only treatment for digoxin overdose that can reverse its effects by its antidote but it’s not available. So, the most successful course of treatment is symptomatic or efficient methods of extracorporeal drug removal. Keywords: Digoxin toxicity, furosemide, hypokalemia, cardiotoxicity, complete heart block, ST segment depression.

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Section: Discussionmentioning

confidence: 99%

Case report on the interaction between furosemide and digoxin that caused digoxin toxicity

Patel¹,

Patel²,

Patel³

et al. 2022

J. Drug Delivery Ther.

View full text Add to dashboard Cite

show abstract

“…Cardiac glycosides, such as digitalis and digoxin, have been used in clinical practice for a long time. This medicine was approved by the FDA in 1954 and is used to treat a variety of cardiac conditions including atrial flutter, atrial fibrillation, and heart failure with accompanying symptoms (Grubb & Mentz 2020).…”

Section: Introductionmentioning

confidence: 99%