Pharmacological investigations of the anti-diabetic effect of Cortex Moutan and its active component paeonol

Lau, Clara Bik San; Chan, Chung Man; Chan, Yiu-Pong; Lau, Kin Mang; Lau, David Tai-Wai; Lam, F.C.; Law, W.T.; Che, Chun‐Tao; Leung, Ping Chung; Fung, Kwok‐Pui; Ho, Yu‐Ling; Lau, Clara Bik‐San

doi:10.1016/j.phymed.2007.01.007

Cited by 123 publications

(75 citation statements)

References 16 publications

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“…Previous investigations of this medicinal plant focused on paeonol, paeoniflorin and their analogs as the major bioactive constituents in the root bark (also called Cortex Moutan) (4,5). Nevertheless, researchers have also been interested in other parts of this medicinal plant, such as the flowers, fruits and seeds (6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

Anti‑proliferative and anti‑metastasis effects of ten oligostilbenes from the seeds of Paeonia suffruticosa on human cancer cells

Gao

2017

Oncol Lett

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Abstract. Paeonia suffruticosa from the section Moutan of the genus Paeonia is an important Chinese medicinal herb. In our previous study, 10 oligostilbenes from the seeds of P. suffruticosa, including trans-resveratrol and its dimers and trimers, were isolated and identified. In the present study, the anti-proliferative effects of these 10 oligostilbenes were systemically evaluated in a panel of human lung, breast and bone cancer cell lines, and their apoptotic effects were analyzed using a high-content multiplex apoptosis assay and a fluorescent caspase-3/7 assay. Furthermore, their anti-metastasis effects were examined in an invasive breast cancer cell line. Among the ten compounds, two resveratrol dimers, trans-and cis-gnetin H, showed the most potent anti-proliferative and anti-metastasis effects. All trans-oligostilbenes were more effective than their cis-forms, and trimers of resveratrol were more effective than dimers and the resveratrol isomer. The structure-activity relationships revealed that the polymerization degree, the double bond in the stilbene skeleton, and the steric arrangement and conformation of oligostilbenes obviously affected their antitumor potential. The results from this study provide valuable information for future semi-synthesis of resveratrol derivatives to develop novel cancer chemopreventive agents.

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Section: Introductionmentioning

confidence: 99%

Anti‑proliferative and anti‑metastasis effects of ten oligostilbenes from the seeds of Paeonia suffruticosa on human cancer cells

Gao

2017

Oncol Lett

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“…Paeonol has been shown to have diverse effects on different cell types in various experimental conditions. The reported effects of paeonol include anti-oxidant [17], anti-diabetic [18], and anxiolytic-like [19] activities as well as apoptosis-inducing effects [20]. Anti-infl ammatory effects of paeonol were demonstrated in a study with carrageenan-evoked thermal hyperalgesia model animals [13].…”

Section: Introductionmentioning

confidence: 99%

A genome-wide microarray analysis reveals anti-inflammatory target genes of paeonol in macrophages

et al. 2008

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“…Paeonol (4-methoxy-2-hydroxyacetophenone), an active compound from the root bark of Paeonia suffruticosa, is used in traditional Chinese medicines (17,18). Paeonol possesses various pharmacological properties, including antioxidant, anti-inflammatory and immunomodulatory effects (19)(20)(21).…”

Section: Introductionmentioning

confidence: 99%

Paeonol enhances the sensitivity of human ovarian cancer cells to radiotherapy-induced apoptosis due to downregulation of the phosphatidylinositol-3-kinase/Akt/phosphatase and tensin homolog pathway and inhibition of vascular endothelial growth factor

Zhou¹,

Sun²,

Cheng

2017

Experimental and Therapeutic Medicine

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Abstract. Radiotherapy is a vital and effective method to treat solid tumors. However, in many tumor types, development of resistance of cancer cells and cytotoxicity in normal tissues presents a major therapeutic problem. It is therefore crucial to identify and develop novel sensitizing agents that may improve the response to radiation therapy without causing any adverse effects. The present study aimed to investigate whether paeonol, a bioactive flavonoid, was able to confer sensitivity to radiation in human ovarian cancer cells. The human ovarian cancer cell lines SKOV-3 and OVCAR-3 were exposed to varying doses of radiation (2, 4 or 6 Gy) in the presence or absence of paeonol (25, 50 or 100 µM). Radiosensitivity was assessed by measuring cell viability using a CCK-8 assay and Annexin V/PI staining. Expression of vascular endothelial growth factor (VEGF), hypoxia inducible factor-1α (HIF-1α), proteins of the phosphatidylinositol-3-kinase (PI3K)/Akt pathway and apoptotic pathway proteins [caspase-3, Bcl-2-associated death promoter, B-cell lymphoma (Bcl)-2, Bcl-2-associated X and Bcl-extra large (Bcl-xL)] were also assessed. Paeonol treatment enhanced apoptosis of SKOV-3 and OVCAR-3 cells that were exposed to radiation. The expression of Bcl-2 and Bcl-xL were markedly upregulated in these cells. Treatment with paeonol concentrations of 50 and 100 µM caused a significant downregulation of VEGF, HIF-1α and PI3K/Akt pathway proteins. Paeonol effectively enhanced the sensitivity of ovarian cancer cells to radiation by significantly altering regulation of the proteins of the PI3K/Akt pathway, in addition to downregulating VEGF and HIF-1α.

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Pharmacological investigations of the anti-diabetic effect of Cortex Moutan and its active component paeonol

Cited by 123 publications

References 16 publications

Anti‑proliferative and anti‑metastasis effects of ten oligostilbenes from the seeds of Paeonia suffruticosa on human cancer cells

Anti‑proliferative and anti‑metastasis effects of ten oligostilbenes from the seeds of Paeonia suffruticosa on human cancer cells

A genome-wide microarray analysis reveals anti-inflammatory target genes of paeonol in macrophages

Paeonol enhances the sensitivity of human ovarian cancer cells to radiotherapy-induced apoptosis due to downregulation of the phosphatidylinositol-3-kinase/Akt/phosphatase and tensin homolog pathway and inhibition of vascular endothelial growth factor

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