Pharmacological Investigation of Phoenix dactylifera L. in Azithromycin Induced Toxicity

Protective Effect of Quercetin on Azithromycin Induced Hepatotoxicity and Nephrotoxicityin Wistar Rats

“…In the present study increased activities of liver enzymes (AST and ALT) and total serum bilirubin concentration in serum of rats which attributed to the liver dysfunction. These results are in consistence with previous reports for drug induced liver toxicity (Cascaval and Lancaster, 2001;Chandrupatla et al, 2002;Suriawinata and Min, 2002;Baciewicz et al, 2005;Charest et al, 2010;Das, 2011;Maggioli et al, 2011;Olayinka and Ore, 2014;Martinez et al,2015 andMobasher Ahmad et al, 2018). However, Paulose et al, (2016) reported liver ALT values were significantly decreased in azithromycin treated group, indicating the hepatotoxic potential of the antibiotic at 30mg/kg body weight because once the cell death happened, the source of enzyme declined.…”

“…Whereas, BUN concentration did not show any significant variation. Increased serum creatinine concentration and BUN level observed by Soni et al, (2004); Persico et al, (2011); Olayinka and Ore (2014) and Mobasher Ahmad et al, (2018). In this experiment quercetin significantly recovered the creatinine concentration in the serum of rats indicating its protective effect.…”

The protective effect of rutin supplement in Azithromycin-induced thyroid gland gland toxicity in male albino rats

“…The results of this study showed that there was a significant decrease in the thyroid enzymes T3 and T4 in the groups that were treated with azithromycin, and this decrease occurred due to the toxic effects caused by the drug on the thyroid gland cells through its generation of free radicals and ROS, and this is consistent with the results presented by the researchers [22,23] who indicated that azithromycin works to generate free radicals that were the main cause of hepatotoxicity and significant damage to cell membranes, which caused leakage of hepatic enzymes into the serum. Researcher [24[his group (2017) indicated that macrolides induce hepatotoxicity through the production of free radicals and the production of ROS.…”