Pharmacological investigation of Ocimum gratissimum in rodents

Aziba, Peter I.; Bass, David; Elegbe, Y.

doi:10.1002/(sici)1099-1573(199908/09)13:5<427::aid-ptr467>3.0.co;2-t

Cited by 39 publications

(24 citation statements)

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“…Also, Chromolaena odorata, Nicotiana tabacum, Ocimum gratissimum and Xylopia aethiopica, each had the UMi of 0.167. These plants have been cited in many herbal remedies [69][70][71][72][73]. Vernonia was the only genus in which two species; V. amygdalina (UMi 0.125) and V. cinerea (UMi 0.042) was encountered in the survey.…”

Section: Resultsmentioning

confidence: 99%

Ethno-medicines for Mosquito Transmitted Diseases from South-western Nigeria

Sonibare¹,

Okorie²,

Aremu³

et al. 2015

JNR

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Ipomoea reniformis Chaos is claimed in Indian traditional medical practice to be useful in the treatment of epilepsy and neurological disorders. In the present study, pretreatment effect of methanolic extract of Ipomoea reniformis on epilepsy and psychosis was evaluated in rodents using standard procedures. Besides evaluating epileptic and behavioral parameters, neurotransmitters such as Gamma-Amino Butyric Acid (GABA) in epilepsy and in psychosis dopamine, noradrenaline and serotonin contents in the rodent brain were estimated. The extract pretreatment reduced maximal electro shock; Isoniazid (INH) and Pentylenetetrazole (PTZ) induced seizures and also significantly inhibited the attenuation of brain GABA levels by INH and PTZ in mice. These results suggested that the observed beneficial effect in epilepsy may be by enhancing the GABAergic system. The test drug also inhibited the apomorphine induced climbing and stereotyped behavior and showed significantly reduced levels of brain dopamine, noradrenaline and serotonin which may be due to blocking of central dopaminergic, noradrenergic and serotonergic pathways or by enhancing the GABAergic system. The results obtained in present study suggest that the title plant possesses antiepileptic and antipsychotic activities in rodents.

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Section: Resultsmentioning

confidence: 99%

Ethno-medicines for Mosquito Transmitted Diseases from South-western Nigeria

Sonibare¹,

Okorie²,

Aremu³

et al. 2015

JNR

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“…This plant has been prepared in a variety of forms for consumption as food spice or traditional herb in many Asian and African countries since ancient time 12-19. Recent studies also demonstrate many therapeutic activities of the OG aqueous extract (OGE), including anti-inflammation 17, 20, analgesic and spasmolytic activities 21, antidiarrheal activity 13, antihyperglycemic activity 22, and improvement of phagocytic function 23. Notably, this extract has also shown potential properties to protect the user from hazardous bio-organisms, such as anthelminthic or insect-repellant properties, antibacterial, antifungal, and antiviral activity 24-28.…”

Section: Introductionmentioning

confidence: 99%

Ocimum gratissmum aqueous extract reduces plasma lipid in hypercholesterol-fed hamsters

et al. 2016

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Objectives: Hyperlipidemia is a significant risk factor in the development of atherosclerosis and related diseases which are major health problem in many developed and developing countries that can lead to fatality due to the changes in lifestyle and dietary habits in this modern age.Methods: In the present study, the Ocimum gratissimum aqueous extract (OGE) was tested for the lowering effect on the serum lipid level of male hamsters on a high-fat (12%) and high-cholesterol (0.2%) diet (HFCD).Results: The results showed that the levels of serum high-density-lipoprotein-cholesterol (HDL-C) low-density-lipoprotein-cholesterol (LDL-C), total cholesterol (TC), and triglycerols (TG) were increased in the HFCD group (113±11, 259±87, 629±175 and 625±262, respectively), as compared to the control normal diet group (51±8, 19±5, 77±16 and 101±44, respectively). When co-treated with various doses (10 and 20 mg/kg) of the OGE or rosuvastatin, the rats exhibited the restoration of normal serum LDL-C, TC, and TG levels.Conclusion: Therefore, we suggest that the Ocimum gratissimum aqueous extract may have the potential function of lowering serum lipid in rats.

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“…OG is also commonly used in folk medicine (Onajobi, 1986;Ilori et al, 1996). Evaluation of the biological activities of OG revealed that OG possesses many therapeutic functions mainly because of its abundant antioxidants (Atal et al, 1986;Lin et al, 1995a, b;Aziba et al, 1999;Aguiyi et al, 2000;Ayisi and Nyadedzor, 2003;Chaturvedi et al, 2007;Nangia-Makker et al, 2007;George et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Dietary Supplementation of <i>Ocimum Gratissimum </i>Improves Immune Response without Affecting the Growth Performance and Blood Characteristics in Taiwan Country Chicken

et al. 2014

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Ocimum gratissimum (OG) was investigated in this study to determine its effect on the immune capability of black-feathered Taiwan country chickens. A total of 90 four-week-old male chickens were randomly assigned to a control group, which was fed with basal diet (BD), and two experimental groups, which were fed with a 0.2 and 0.4 g/kg OG-supplemented BD. During the experimental period, feed intake and body weight were recorded every two weeks to determine growth performance and feed efficiency. Blood was collected from the brachial vein of the chicken wing to obtain blood characteristics at 12 weeks of age. OG supplementation yielded no significant difference in growth performance and blood characteristics. The hemagglutination test showed that, compared with the control, the 0.4 g/kg BD group was able to maintain a significantly higher antibody titer level over two weeks after goat red blood cells injection (p＜0.05), suggesting that 0.4 g/kg improves humoral immune response. The phytohemagglutinin test showed that wattle swelling in the 0.2-0.4 g/kg BD groups was reduced more significantly than that in the control group (p＜0.05), suggesting that OG supplementation reduces cell-mediated immune response. Taken together, these findings suggest that although OG does not enhance growth or blood characteristics, the inverse changes in humoral and cell-mediated immune response may improve the overall health of the chickens.

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Pharmacological investigation of Ocimum gratissimum in rodents

Cited by 39 publications

References 1 publication

Ethno-medicines for Mosquito Transmitted Diseases from South-western Nigeria

Ethno-medicines for Mosquito Transmitted Diseases from South-western Nigeria

Ocimum gratissmum aqueous extract reduces plasma lipid in hypercholesterol-fed hamsters

Dietary Supplementation of <i>Ocimum Gratissimum </i>Improves Immune Response without Affecting the Growth Performance and Blood Characteristics in Taiwan Country Chicken

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