Pharmacological investigation of analgesic and antipyretic activities of methanol extract of the whole part of Aeginetia indica

Reza, Md. Sharif; Jashimuddin,; Ahmed, Jamiuddin; Abeer, Muhammad; Naznin, Nura Ershad; Jafrin, Sarah; Haque, Enamul; Barek, Md. Abdul; Daula, A F M Shahid Ud

doi:10.1016/j.jep.2021.113915

Cited by 9 publications

(11 citation statements)

References 33 publications

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“…Comparable results were described from Ghauri et al ( 2021 ) in which the methanolic plant extract of Euphorbia granulata revealed substantial analgesic activity at 200 mg/kg. Relatedly, Reza et al ( 2021 ) have reported maximal activity at 200 mg/kg from Aeginetia indica methanol extract. Malairajan et al ( 2006 ) have reported analgesic activities from various Indian medicinal plants.…”

Section: Resultsmentioning

confidence: 90%

Effects of Ottonia anisum plant extract on local anesthetic, analgesic, anti-inflammatory and HCl‑induced acute lung injury activities: a study in animal models

Liu,

Wang,

Yue

et al. 2023

Bioresour. Bioprocess.

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Ottonia anisum (O. anisum), belonging to the family Piperaceae, is renowned for its medicinal properties. The plant is rich in alkaloids, terpenoids and flavonoids with recorded bioactivities. The stems, roots, and leaves, of the O. anisum have been extensively used in the folk medicine. Therefore, the present study was conducted to examine the pharmacological activities of O. anisum root extract. Methanolic root extract of O. anisum was assessed for local anesthetic, analgesic, anti-inflammatory and HCl-induced acute lung injury activities in animal models. Local anesthetic activity assessed in frog and guinea pigs through foot withdrawal reflex and intradermal wheal method, respectively, revealed the dose-dependent onset time of anesthesia response. In the case of HCl-induced ALI, the mice group orally administered with O. anisum extract were assessed for bronchoalveolar lavage fluid (BLF) contents, oxidative stress, and proinflammatory molecules. The analysis revealed the reduction in inflammatory molecules, neutrophils, and oxidative stress in the extract treated mice group. In addition, the redox homeostasis, reduced GSH and the catalase activity was found to be restored in the treated groups. Intriguingly, the genes associated with the NFkB expression was found to be downregulated in O. anisum extract treated groups. Moreover, the extract unveiled the significant analgesic and anti-inflammatory activities. Overall, the findings emphasize the clinical applicability of O. anisum extract in the treatment of ALI as well as the potential usage in local anesthetic, analgesic, and anti-inflammatory agents during the treatments. Graphical Abstract

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Section: Resultsmentioning

confidence: 90%

Effects of Ottonia anisum plant extract on local anesthetic, analgesic, anti-inflammatory and HCl‑induced acute lung injury activities: a study in animal models

Liu,

Wang,

Yue

et al. 2023

Bioresour. Bioprocess.

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“… 2 In another experiment, the temperature was recorded at 30 minutes, 1 hour, 2 hours, 3 hours, and 24 hours after treatment. 3 …”

Section: Dear Editormentioning

confidence: 99%

“…2 In another experiment, the temperature was recorded at 30 minutes, 1 hour, 2 hours, 3 hours, and 24 hours after treatment. 3 Preparing medicinal plants for experimentation is the first and most important stage in producing high-quality research results. Before beginning the process, it involves extracting and determining the quantity and quality of bioactive components.…”

Section: Dear Editormentioning

confidence: 99%

Response to Article “Antipyretic Potential of 80% Methanol Extract and Solvent Fractions of Bersama Abyssinica Fresen. (Melianthaceae) Leaves Against Yeast-Induced Pyrexia in Mice” [Letter]

Intan¹,

Noviantari²,

Alegantina³

2023

JEP

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“…Many edible plants and herbs have been used as traditional medicines to reduce the risk of NCDs [ 2 ]. Aeginetia indica L. (also known as “Dok Din” in Thai) is a herbaceous annual plant that is parasitic on roots of rice, sugar cane, and bamboo and is widely distributed throughout China, India, Bangladesh, Myanmar, and other Southeast Asian countries [ 3 ]. The plant grows to 15–30 cm high with one to several slender and glabrous peduncles arising from a fleshy rhizome of interwoven roots and purple or purplish-red solitary flowers, which bloom only in the rainy season (September to October in Thailand) [ 4 ] ( Figure 1 ).…”

Section: Introductionmentioning

confidence: 99%

Optimized Conditions for the Extraction of Phenolic Compounds from Aeginetia indica L. and Its Potential Biological Applications

On-Nom,

Thangsiri,

Inthachat

et al. 2024

Molecules

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Aeginetia indica L., a parasitic root in the Orobanchaceae family, is used as a food colorant in traditional Thai desserts. However, scant information is available on its food applications as well as medicinal properties, while overharvesting by the local people has severely depleted wild plant populations. This research, thus, aimed to extract optimized total phenolic content (TPC) in varying extraction conditions using response surface methodology (RSM) and the Box–Behnken design (BBD). Results indicated that an extraction temperature of 90 °C, 80% (v/v) aqueous ethanol, and 0.5% (w/v) solid-to-liquid ratio yielded the highest TPC at 129.39 mg gallic acid equivalent (GAE)/g dry weight (DW). Liquid chromatography–electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) identified the predominant phenolics as apigenin (109.06 mg/100 g extract) and luteolin (35.32 mg/100 g extract) with trace amounts of naringenin and rutin. Under the optimal extraction condition, the plant extract exhibited antioxidant activities of 5620.58 and 641.52 µmol Trolox equivalent (TE)/g DW determined by oxygen radical absorbance capacity (ORAC) and ferric ion reducing antioxidant power (FRAP) assay, while the scavenging capacity of total radicals at 50% (SC50) was determined to be 135.50 µg/mL using 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay. The plant extract also exhibited inhibitory activities against the key enzymes relevant to type II diabetes, obesity, and Alzheimer’s disease, suggesting the potential for medicinal applications.

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Pharmacological investigation of analgesic and antipyretic activities of methanol extract of the whole part of Aeginetia indica

Cited by 9 publications

References 33 publications

Effects of Ottonia anisum plant extract on local anesthetic, analgesic, anti-inflammatory and HCl‑induced acute lung injury activities: a study in animal models

Effects of Ottonia anisum plant extract on local anesthetic, analgesic, anti-inflammatory and HCl‑induced acute lung injury activities: a study in animal models

Response to Article “Antipyretic Potential of 80% Methanol Extract and Solvent Fractions of Bersama Abyssinica Fresen. (Melianthaceae) Leaves Against Yeast-Induced Pyrexia in Mice” [Letter]

Optimized Conditions for the Extraction of Phenolic Compounds from Aeginetia indica L. and Its Potential Biological Applications

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