Pharmacological interventions in the prevention of type 2 diabetes

Henness, Sheridan

doi:10.1097/01.med.0000261735.91562.06

Cited by 8 publications

(3 citation statements)

References 15 publications

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“…Lifestyle modification is the primary intervention with overweight and obese individuals with prediabetes because a healthy lifestyle is associated with a high risk of T2D as well as many other chronic diseases 21. Nonetheless, drug therapy to prevent T2D in people with prediabetes is constantly being studied 22. A systematic review reported that no single agent could be recommended to delay or prevent T2D.…”

Section: What Is Prediabetes?mentioning

confidence: 99%

“…Surprisingly, only a few well-designed studies have looked at diet alone25,39–42 as a strategy to improve glycemic control or body weight in individuals with prediabetes 22,35–38. Nonetheless, some studies with both diet and exercise interventions showed significant changes in glycemic control or body weight in individuals with prediabetes.…”

Section: Diet Glycemic Control and Body Weightmentioning

confidence: 99%

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Independent and combined effect of diet and exercise in adults with prediabetes

Sénéchal

Slaght

Bharti

et al. 2014

DMSO

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Prediabetes is defined as impaired fasting glucose and/or impaired glucose tolerance. Impaired fasting glucose is usually defined as fasting blood glucose between 5.6 mmol/L and 6.9 mmol/L (100.8–124.2 mg/dL), and impaired glucose tolerance is the 2-hour oral glucose tolerance test of 7.8–11.0 mmol/L (140.4–198.0 mg/dL). Most individuals with prediabetes are overweight or obese and are at greater risk of type 2 diabetes (T2D). The first line of treatment for individuals with prediabetes is lifestyle modification, including diet and exercise. The aim of this review, through the revision of primarily randomized control trials, is to discuss the independent and combined effect of diet and exercise on the incidence of T2D, glycemic control, and weight loss in adults with prediabetes. Based on the available literature, lifestyle modification combining both diet and exercise is effective at reducing the incidence of T2D and improving glycemic control, even without a significant reduction in body weight. Thus, it is unclear whether weight loss, through lifestyle modification, is a cornerstone for improving glycemic control in individuals with prediabetes. The independent effect of diet or exercise alone on the improvement in glycemic control and/or reduction in body weight in individuals with prediabetes still requires more studies to draw a clear conclusion, considering the quality and quantity of available studies. As of now, the best diet and/or exercise program to improve glycemic control and body weight in adults with prediabetes is unknown.

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Section: What Is Prediabetes?mentioning

confidence: 99%

Section: Diet Glycemic Control and Body Weightmentioning

confidence: 99%

Independent and combined effect of diet and exercise in adults with prediabetes

Sénéchal

Slaght

Bharti

et al. 2014

DMSO

View full text Add to dashboard Cite

show abstract

“…However, more effective and safe medicines are required. 1) Thiazolidinedione-type compounds such as pioglitazone and rosiglitazone are potent insulin sensitizers currently used clinically to treat type 2 diabetes. Thiazolidinedionetype compounds were originally identified based on their antihyperglycemic activity, but they are also able to improve other abnormalities associated with type 2 diabetes, such as hyperlipidemia, atherosclerosis, hypertension, and chronic inflammation.…”

Section: Introductionmentioning

confidence: 99%

Search for New Type of PPARγ Agonist-Like Anti-diabetic Compounds from Medicinal Plants

Matsuda

Nakamura

Yoshikawa

2014

Biological & Pharmaceutical Bulletin

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Potent ligands of peroxisome proliferator-activated receptor γ (PPARγ) such as thiazolidinediones (pioglitazone, troglitazone, etc.) improve insulin sensitivity by increasing the levels of adiponectin, an important adipocytokine associated with insulin sensitivity in adipose tissue. Several constituents from medicinal plants were recently reported to show PPARγ agonist-like activity in 3T3-L1 cells, but did not show agonistic activity at the receptor site different from thiazolidinediones. Our recent studies on PPARγ agonist-like constituents, such as hydrangenol and hydrangeic acid from the processed leaves of Hydrangea macrophylla var. thunbergii, piperlonguminine and retrofractamide A from the fruit of Piper chaba, and tetramethylkaempferol and pentamethylquercetin from the rhizomes of Kaempferia parviflora, are reviewed.

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Alteration of 11β-hydroxysteroid dehydrogenase type 1 in skeletal muscle in a rat model of type 2 diabetes

Ming

et al. 2009

Mol Cell Biochem

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Recent investigations have demonstrated that activation of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) in liver and adipose tissue is closely related to the pathogenesis of obesity and diabetes. However, the relationship between alteration of 11beta-HSD1 and the pathogenesis of type 2 diabetes in skeletal muscle is still unclear. A rat model of Type 2 diabetes was developed by high fat diet feeding combined with multiple low dose streptozotocin injection (30 mg/kg, i.p. twice). Intraperitoneal glucose tolerance test, insulin tolerance test were performed. Fasting blood glucose, fasting insulin, total cholesterol, triglyceride were measured. The protein and mRNA level of 11beta-HSD1 and glucocorticoid receptor in gastrocnemius muscle were determined. The alteration of insulin signaling pathway related protein was investigated. We found that the protein levels of 11beta-HSD1 and glucocorticoid receptor were significantly increased (P < 0.05); the mRNA level of 11beta-HSD1 was also elevated (P < 0.05); the mRNA level of glucocorticoid receptor was decreased (P < 0.05). After insulin stimulation, diabetic rats had no significant changes in the level of the insulin receptor beta-subunit (IR-beta), AKT, as in phosphorylated AKT in the gastrocnemius muscle compared to its basal state. Similar results were observed in the protein expression level of glucose transporter 4 (GLUT4). Our data indicate that the alteration of 11beta-HSD1 at protein and mRNA level may be related to the abnormality of insulin signal pathway in skeletal muscle, this effect may be mediated by glucocorticoid receptor.

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Pharmacological interventions in the prevention of type 2 diabetes

Cited by 8 publications

References 15 publications

Independent and combined effect of diet and exercise in adults with prediabetes

Independent and combined effect of diet and exercise in adults with prediabetes

Search for New Type of PPARγ Agonist-Like Anti-diabetic Compounds from Medicinal Plants

Alteration of 11β-hydroxysteroid dehydrogenase type 1 in skeletal muscle in a rat model of type 2 diabetes

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