Pharmacological interventions for ADHD symptoms in children with fetal alcohol spectrum disorders (FASD)

Peadon, Elizabeth; Thomas, D. E.; Elliott, Elizabeth J

doi:10.1002/14651858.cd009724.pub2

Cited by 5 publications

(2 citation statements)

References 19 publications

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“…66 Researchers describe at least 11 different neuroanatomical theories of ADHD. 67 These theories can be categorized into two domains. The bottom-up theories propose disturbances in subcortical regions, such as the thalamus, and hypothalamus and reticular activating systems are responsible for ADHD symptomology.…”

Section: Neurobiology Of Attention Deficit Hyperactivity Disordermentioning

confidence: 99%

Overview of attention deficit hyperactivity disorder in young children

Singh¹,

Yeh²,

Verma³

et al. 2015

Health Psych Res

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Attention deficit hyperactivity disorder (ADHD) is a complex disorder, which can be seen as a disorder of life time, developing in preschool years and manifesting symptoms (full and/or partial) throughout the adulthood; therefore, it is not surprising that there are no simple solutions. The aim of this paper is to provide a short and concise review which can be used to inform affected children and adults; family members of affected children and adults, and other medical, paramedical, non-medical, and educational professionals about the disorder. This paper has also tried to look into the process of how ADHD develops; what are the associated problems; and how many other children and adults are affected by such problems all over the world basically to understand ADHD more precisely in order to develop a better medical and or non-medical multimodal intervention plan. If preschool teachers and clinicians are aware of what the research tells us about ADHD, the varying theories of its cause, and which areas need further research, the knowledge will assist them in supporting the families of children with ADHD. By including information in this review about the connection between biological behavior, it is hoped that preschool teachers and clinicians at all levels will feel more confident about explaining to parents of ADHD children, and older ADHD children themselves about the probable causes of ADHD.

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Section: Neurobiology Of Attention Deficit Hyperactivity Disordermentioning

confidence: 99%

Overview of attention deficit hyperactivity disorder in young children

Singh¹,

Yeh²,

Verma³

et al. 2015

Health Psych Res

View full text Add to dashboard Cite

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“…Melatonin supplementation can help with sleep disorders. Some subjects with FASD who exhibit sleep difficulties may respond positively to melatonin supplementation to aid sleep onset [ 79 ].…”

Section: Discussionmentioning

confidence: 99%

Novel Interventions on Comorbidities in Patients with Fetal Alcohol Spectrum Disorder (FASD): An Integrative Review

Andreu-Fernández,

La Maida,

Marquina

et al. 2024

Biomedicines

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Prenatal exposure to alcohol can cause Fetal Alcohol Spectrum Disorders (FASDs) after birth, encompassing a spectrum of physical, cognitive, and behavioral abnormalities. FASD represents a severe non-genetic disability avoidable through alcohol abstinence during pregnancy and when planning it. Clinical severity depends on alcohol impact, symptomatology, and resulting disabilities. FASD is a permanent disability with no recognized specific medical care. Conversely, secondary FASD-related disabilities can be symptomatically treated. This integrative review aims to provide information about the novel pharmacological treatments of FASD-associated comorbidities by selecting the last ten years of studies carried out on animals and humans. PRISMA guidelines were followed to search human/animal model studies of pharmacological interventions on FASD comorbidities, using different databases (PubMed, Cochrane, etc.). From 1348 articles, 44 met the criteria after full-text analysis. Firstly, all the reported studies point out that early diagnosis and tailored interventions are the principal tools to reduce FASD-related secondary disabilities, due to the fact that there is currently no approved pharmacological treatment for the tissue damage which produces FASD. Despite limitations in study designs and small sample sizes, these review results highlight how the treatment strategies of children with FASD have changed. In the past, studies focused on treating symptoms, but in the last years, researchers have turned their attention to the prevention targeting central nervous system embryogenesis. Novel treatments like choline and natural antioxidants and nutritional supplements are the most investigated treatments in humans with promising results. More follow-up studies need to be performed, to confirm and generalize reported efficacy to a wide sample size.

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