Pharmacological Interventions and Rehabilitation Approach for Enhancing Brain Self-repair and Stroke Recovery

Szelenberger, Rafał; Kostka, Joanna; Saluk‐Bijak, Joanna; Miller, Elżbieta

doi:10.2174/1570159x17666190726104139

Cited by 53 publications

(35 citation statements)

References 122 publications

(92 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Changing sleep position and ameliorate hypoxia [87] Improving stroke outcomes [87] Surgery Airway reconstruction to benefit ventilation [88] Better brain recovery [91] CSA ASV/mechanical ventilation Improving hypoventilation and maintaining blood-gas balance [65] Beneficial outcomes in stroke patients [97] RBD Clonazepam Binding GABA receptor and inhibiting neural excitability [151] Improving the outcome of post-stroke movement disorders [152] Melatonin Activating melatonin receptor to decrease violent attacks and improve dream enactment [21] Brain protection after stroke [153,154] Fluoxetine Inhibiting serotonin re-uptake and playing antidepressant effect [155] Enhancing motor recovery in ischemic stroke [156,157]…”

Section: Levodopamentioning

confidence: 99%

Sleep Disorders in Stroke: An Update on Management

2021

View full text Add to dashboard Cite

Stroke is a leading cause of disability and mortality all over the world. Due to an aging population, the incidence of stroke is rising significantly, which has led to devastating consequences for patients. In addition to traditional risk factors such as age, hypertension, hyperlipidemia, diabetes and atrial fibrillation, sleep disorders, as independent modifiable risk factors for stroke, have been highlighted increasingly. In this review, we provide an overview of common types of current sleep disturbances in cerebrovascular diseases, including insomnia, hypersomnia, breathing-related sleep disorders, and parasomnias. Moreover, evidence-based clinical therapeutic strategies and pitfalls of specific sleep disorders after stroke are discussed. We also review the neurobiological mechanisms of these treatments as well as their effects on stroke. Since depression after stroke is so prevalent and closely related to sleep disorders, treatments of post-stroke depression are also briefly mentioned in this review article.

show abstract

Section: Levodopamentioning

confidence: 99%

Sleep Disorders in Stroke: An Update on Management

2021

View full text Add to dashboard Cite

show abstract

“…Thus, further studies on the above reported drugs are needed in order to reach definitive conclusions. Moreover, it would be also interesting to include some studies on the role of other drugs in post-stroke aphasia, such as Fluoxetine, Niacin, Inosine, and Citicoline, which have already been used in post-stroke patients in order to improve motor recovery but not in post-stroke aphasia [100].…”

Section: Discussionmentioning

confidence: 99%

Innovative Approaches to Aphasia Rehabilitation: a Review on Efficacy, Safety and Controversies

Picano¹,

Quadrini²,

Pisano³

et al. 2020

Preprint

View full text Add to dashboard Cite

Aphasia is one of the most socially disabling post-stroke deficits. Although traditional therapies have been shown to induce adequate clinical improvement, aphasic symptoms often persist. Therefore, new rehabilitation techniques which act as a substitute or as an adjunct to traditional approaches are urgently needed. The present review provides an overview of the efficacy and safety of the most innovative approaches which have been proposed over the last twenty years. First, we examined the effectiveness of the pharmacological approach, principally used as an adjunct to language therapy, reporting the mechanism of action of each single drug for the recovery of aphasia. Results are conflicting but promising. Secondly, we discussed the application of Virtual Reality (VR) which has been proved to be useful since it potentiates the ecological validity of the language therapy by using virtual contexts which simulate real-life everyday contexts. Finally, we focused on the use of Transcranial Direct Current Stimulation (tDCS), both discussing its applications at the cortical level and highlighting a new perspective, which considers the possibility to extend the use of tDCS over the motor regions. Although the review revels an extraordinary variability among the different studies, substantial agreement has been reached on some general principles, such as the necessity to consider tDCS only as an adjunct to traditional language therapy.

show abstract

“…Indeed, Fluoxetine enhances serotonin levels in certain brain areas; while Inosine exerts powerful axon-promoting effects; finally, Citicoline is involved in the synthesis of myelin leading to improvement in neuronal membrane integrity. Right now, the exact mechanisms of action of these drugs are not completely known but they seem promising since they have already been successfully used in post-stroke patients for motor recovery [ 101 ].…”

Section: Pharmacological Approachmentioning

confidence: 99%

Adjunctive Approaches to Aphasia Rehabilitation: A Review on Efficacy and Safety

et al. 2021

View full text Add to dashboard Cite

Aphasia is one of the most socially disabling post-stroke deficits. Although traditional therapies have been shown to induce adequate clinical improvement, aphasic symptoms often persist. Therefore, unconventional rehabilitation techniques which act as a substitute or as an adjunct to traditional approaches are urgently needed. The present review provides an overview of the efficacy and safety of the principal approaches which have been proposed over the last twenty years. First, we examined the effectiveness of the pharmacological approach, principally used as an adjunct to language therapy, reporting the mechanism of action of each single drug for the recovery of aphasia. Results are conflicting but promising. Secondly, we discussed the application of Virtual Reality (VR) which has been proven to be useful since it potentiates the ecological validity of the language therapy by using virtual contexts which simulate real-life everyday contexts. Finally, we focused on the use of Transcranial Direct Current Stimulation (tDCS), both discussing its applications at the cortical level and highlighting a new perspective, which considers the possibility to extend the use of tDCS over the motor regions. Although the review reveals an extraordinary variability among the different studies, substantial agreement has been reached on some general principles, such as the necessity to consider tDCS only as an adjunct to traditional language therapy.

show abstract

Pharmacological Interventions and Rehabilitation Approach for Enhancing Brain Self-repair and Stroke Recovery

Cited by 53 publications

References 122 publications

Sleep Disorders in Stroke: An Update on Management

Sleep Disorders in Stroke: An Update on Management

Innovative Approaches to Aphasia Rehabilitation: a Review on Efficacy, Safety and Controversies

Adjunctive Approaches to Aphasia Rehabilitation: A Review on Efficacy and Safety

Contact Info

Product

Resources

About