Pharmacological Interaction Between Cannabidiol and Tramadol on Experimental Diabetic Neuropathic Pain: An Isobolographic Analysis

Evans, Allan Arnold; Jesus, Carlos Henrique Alves; Martins, Lucas Latchuk; Fukuyama, Alisson Hideki; Gasparin, Alexia Thamara; Crippa, José Alexandre; Zuardi, Antonio Waldo; Hallak, Jaime Eduardo Cecílio; Genaro, Karina; de Castro Junior, Célio José; Zanoveli, Janaina Menezes; Cunha, Joice Maria da

doi:10.1089/can.2021.0242

Cited by 3 publications

(1 citation statement)

References 46 publications

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“…In this study, the addition of JWH015 reduced the gastrointestinal side effects and conditioned place preference associated with morphine treatment [126]. In contrast, additive, but not synergistic, analgesic effects were observed with combination treatment with cannabidiol and tramadol in the streptozotocin-induced rat model of diabetic neuropathy [127] and with PhAR-DBH-Me and tramadol in a model of cisplatin-induced neuropathy [125]. Ultimately, despite preclinical evidence of the anti-nociceptive effects of cannabinoid receptor 1/2 (CB1/2) agonism and fatty acid amide hydrolase (FAAH) inhibition, translation of these preclinical findings into clinical data has been limited.…”

Section: Additional Combination Therapiesmentioning

confidence: 64%

Combination Drug Therapy for the Management of Chronic Neuropathic Pain

Boccella,

De Filippis,

Giorgio

et al. 2023

Biomolecules

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Chronic neuropathic pain (NP) is an increasingly prevalent disease and leading cause of disability which is challenging to treat. Several distinct classes of drugs are currently used for the treatment of chronic NP, but each drug targets only narrow components of the underlying pathophysiological mechanisms, bears limited efficacy, and comes with dose-limiting side effects. Multimodal therapies have been increasingly proposed as potential therapeutic approaches to target the multiple mechanisms underlying nociceptive transmission and modulation. However, while preclinical studies with combination therapies showed promise to improve efficacy over monotherapy, clinical trial data on their efficacy in specific populations are lacking and increased risk for adverse effects should be carefully considered. Drug-drug co-crystallization has emerged as an innovative pharmacological approach which can combine two or more different active pharmaceutical ingredients in a single crystal, optimizing pharmacokinetic and physicochemical characteristics of the native molecules, thus potentially capitalizing on the synergistic efficacy between classes of drugs while simplifying adherence and minimizing the risk of side effects by reducing the doses. In this work, we review the current pharmacological options for the treatment of chronic NP, focusing on combination therapies and their ongoing developing programs and highlighting the potential of co-crystals as novel approaches to chronic NP management.

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Section: Additional Combination Therapiesmentioning

confidence: 64%

Combination Drug Therapy for the Management of Chronic Neuropathic Pain

Boccella,

De Filippis,

Giorgio

et al. 2023

Biomolecules

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Antinociceptive action of cannabidiol on thermal sensitivity and post-operative pain in male and female rats

Arantes,

Carvalho,

Brandão

et al. 2024

Behavioural Brain Research

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The Impact of Hemp Seed Oil on Drug-Drug Interactions: A Comprehensive Review of Potential Mechanisms and Clinical Implications

Solaimanian,

Rahmani,

Shiri-Shahsavar

2023

Preprint

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Hemp seed oil (HSO), esteemed for its potential health benefits and therapeutic attributes, has garnered substantial attention in recent years. However, the escalating consumption of HSO has engendered apprehensions regarding its potential interactions with pharmaceutical medications, posing the risk of adverse effects or altered drug efficacy. This comprehensive review diligently explores and elucidates the underlying mechanisms through which HSO may interact with a spectrum of drugs, accompanied by an extensive assessment of the clinical ramifications of these interactions. By assiduously unraveling these intricate dynamics, this review equips healthcare professionals and consumers with the knowledge to make judicious decisions concerning the concurrent use of HSO and prescription medications. Moreover, this comprehensive review endeavors to identify and address research gaps, charting a route for future investigations in this critical domain. This review sheds light on HSO's impact on drug-drug interactions (DDIs), delivering invaluable insights for healthcare professionals, researchers, and consumers and fostering the responsible and informed incorporation of this natural product across diverse therapeutic contexts.

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Pharmacological Interaction Between Cannabidiol and Tramadol on Experimental Diabetic Neuropathic Pain: An Isobolographic Analysis

Cited by 3 publications

References 46 publications

Combination Drug Therapy for the Management of Chronic Neuropathic Pain

Combination Drug Therapy for the Management of Chronic Neuropathic Pain

Antinociceptive action of cannabidiol on thermal sensitivity and post-operative pain in male and female rats

The Impact of Hemp Seed Oil on Drug-Drug Interactions: A Comprehensive Review of Potential Mechanisms and Clinical Implications

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