Abstract:Background and Purpose: Traumatic brain injury (TBI) remains a major
public health concern worldwide with unmet effective treatment.
Stimulator of Interferon Genes (STING) protein and its downstream type-I
Interferon (IFN) signaling are now appreciated to be involved in TBI
pathogenesis. Compelling evidence have shown that STING and type-I IFNs
are key in mediating detrimental neuroinflammatory response after TBI,
exacerbating outcome. Therefore, pharmacological inhibition of STING
presents a viable therapeuti… Show more
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