Pharmacological Inhibition of Intracellular Signaling Pathways in Radioresistant Anaplastic Thyroid Cancer

Abstract

Abstract"naplastic thyroid cancer "TC is highly aggressive and has a poor therapeutic response and leads to high mortality. It has been shown that activation of intracellular c-Jun N-terminal kinase JNK and c-""L signaling pathways is one of the manifestations of the highly resistant response to radiotherapy in "TC. Pharmacological inhibition of these pathways in combination with radiotherapy is a potential treatment modality of "TC.