Pharmacological induction of mesenchymal-epithelial transition via inhibition of H2S biosynthesis and consequent suppression of ACLY activity in colon cancer cells

Ascenção, Kelly; Dilek, Nahzli; Augsburger, Fiona; Panagaki, Theodora; Zuhra, Karim; Szabó, Csaba

doi:10.1016/j.phrs.2020.105393

Cited by 46 publications

(66 citation statements)

References 94 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nevertheless, the negative effects of knocking down GFPT2 on cystathionine and SQOR have connected GFPT2 with H2S and further with mitochondrial functions. H2S signaling has recently been reported to facilitate EMT (79,80).…”

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

Glutamine-Fructose-6-Phosphate Transaminase 2 (GFPT2) Is Upregulated in Breast Epithelial–Mesenchymal Transition and Responds to Oxidative Stress

Wang

Karvelsson

Kotronoulas

et al. 2022

Molecular & Cellular Proteomics

View full text Add to dashboard Cite

This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

show abstract

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

Glutamine-Fructose-6-Phosphate Transaminase 2 (GFPT2) Is Upregulated in Breast Epithelial–Mesenchymal Transition and Responds to Oxidative Stress

Wang

Karvelsson

Kotronoulas

et al. 2022

Molecular & Cellular Proteomics

View full text Add to dashboard Cite

show abstract

“…Moreover, the slow H 2 S donor GYY4137 activated the ACLY gene promotor through the induction of the Sp3 transcription factor. Lastly, HMPSNE treatment also attenuated cell migration, consistent with EMT inhibition [ 46 ]. Taken together, the above studies indicate that H 2 S promotes the progression of colon cancer from preneoplastic low-grade dysplastic lesions to metastatic, dedifferentiated colon cancer.…”

Section: H 2 S and Cancermentioning

confidence: 89%

“… A summary of the roles of CBS, 3-MST, and H2S in colon cancer growth, progression, metastasis, and chemotherapy resistance [ 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 ]. …”

Section: Figurementioning

confidence: 99%

Molecular Functions of Hydrogen Sulfide in Cancer

et al. 2021

View full text Add to dashboard Cite

Hydrogen sulfide (H2S) is a gasotransmitter that exerts a multitude of functions in both physiologic and pathophysiologic processes. H2S-synthesizing enzymes are increased in a variety of human malignancies, including colon, prostate, breast, renal, urothelial, ovarian, oral squamous cell, and thyroid cancers. In cancer, H2S promotes tumor growth, cellular and mitochondrial bioenergetics, migration, invasion, angiogenesis, tumor blood flow, metastasis, epithelia–mesenchymal transition, DNA repair, protein sulfhydration, and chemotherapy resistance Additionally, in some malignancies, increased H2S-synthesizing enzyme expression correlates with a worse prognosis and a higher tumor stage. Here we review the role of H2S in cancer, with an emphasis on the molecular mechanisms by which H2S promotes cancer development, progression, dedifferentiation, and metastasis.

show abstract

“…Although up-regulation of 3-MST in different cancer tissues has been confirmed, the underlying mechanism of 3-MST mediated H 2 S signaling is rarely discussed before [ 87 , 94 ]. Recently, several 3-MST inhibitors have been developed and the function of 3-MST in cancer can now be studied through inhibition of 3-MST activity [ 94 , 95 ]. More investigations will be needed to understand the underlying mechanism of 3-MST to evaluate the therapeutic potential of 3-MST specific inhibitors.…”

Section: Regulation Of Hydrogen Sulfide Production In Cancermentioning

confidence: 99%

“…The initial development of cancer metastasis requires cancer cells to gain migration and invasion ability through epithelial to mesenchymal transition (EMT) [ 125 ]. Endogenous H 2 S promotes cancer cell migration and invasion in multiple cancer types, such as prostate cancer [ 45 ], lung cancer [ 101 ], colon cancer [ 95 , 126 ], and liver cancer [ 109 ], partly through induction of ATP citrate lyase (ACLY) to facilitate EMT [ 95 ]. Moreover, NF-κB, a key molecule driving cancer metastasis [ 111 ], is involved in the H 2 S-modulated cancer metastasis through persulfidation.…”

Section: The Role Of Hydrogen Sulfide In Cancermentioning

confidence: 99%

The Hidden Role of Hydrogen Sulfide Metabolism in Cancer

Wang

Chu

Lin

2021

IJMS

View full text Add to dashboard Cite

Hydrogen Sulfide (H2S), an endogenously produced gasotransmitter, is involved in various important physiological and disease conditions, including vasodilation, stimulation of cellular bioenergetics, anti-inflammation, and pro-angiogenesis. In cancer, aberrant up-regulation of H2S-producing enzymes is frequently observed in different cancer types. The recognition that tumor-derived H2S plays various roles during cancer development reveals opportunities to target H2S-mediated signaling pathways in cancer therapy. In this review, we will focus on the mechanism of H2S-mediated protein persulfidation and the detailed information about the dysregulation of H2S-producing enzymes and metabolism in different cancer types. We will also provide an update on mechanisms of H2S-mediated cancer progression and summarize current options to modulate H2S production for cancer therapy.

show abstract

Pharmacological induction of mesenchymal-epithelial transition via inhibition of H2S biosynthesis and consequent suppression of ACLY activity in colon cancer cells

Cited by 46 publications

References 94 publications

Glutamine-Fructose-6-Phosphate Transaminase 2 (GFPT2) Is Upregulated in Breast Epithelial–Mesenchymal Transition and Responds to Oxidative Stress

Glutamine-Fructose-6-Phosphate Transaminase 2 (GFPT2) Is Upregulated in Breast Epithelial–Mesenchymal Transition and Responds to Oxidative Stress

Molecular Functions of Hydrogen Sulfide in Cancer

The Hidden Role of Hydrogen Sulfide Metabolism in Cancer

Contact Info

Product

Resources

About