Pharmacological HDAC3 inhibition alters memory updating in young and old male mice
Chad W. Smies,
Lauren Bellfy,
Destiny S. Wright
et al.
Abstract:Long-term memories are not stored in a stable state but must be flexible and dynamic to maintain relevance in response to new information. Existing memories are thought to be updated through the process of reconsolidation, in which memory retrieval initiates destabilization and updating to incorporate new information. Memory updating is impaired in old age, yet little is known about the mechanisms that go awry. One potential mechanism is the repressive histone deacetylase 3 (HDAC3), which is a powerful negativ… Show more
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