Pharmacological features, health benefits and clinical implications of honokiol

Khatoon, Fahmida; Ali, Sabeeha; Kumar, Vijay; Elasbali, Abdelbaset Mohamed; Alhassan, Hassan H.; Alharethi, Salem Hussain; Islam, Asimul; Hassan, Md. Imtaiyaz

doi:10.1080/07391102.2022.2120541

Cited by 22 publications

(9 citation statements)

References 248 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Honokiol has been shown to extend the lifespan of SOD1-G93A transgenic mice and improve their motor function and the viability of neuroblastoma/spinal cord NSC-34 hybrid cell lines and the morphology of mitochondria in SOD1-G93A cells (Zhou et al 2023 ). Honokiol can promote cell viability and endoplasmic reticulum stress modulation by SIRT1 expression (Khatoon et al 2022 ).…”

Section: Oxidative Stress Diseases Aging and Antioxidant Interventionsmentioning

confidence: 99%

Reactive oxygen species, toxicity, oxidative stress, and antioxidants: chronic diseases and aging

Jomova,

Raptova,

Alomar

et al. 2023

Arch Toxicol

363

View full text Add to dashboard Cite

A physiological level of oxygen/nitrogen free radicals and non-radical reactive species (collectively known as ROS/RNS) is termed oxidative eustress or “good stress” and is characterized by low to mild levels of oxidants involved in the regulation of various biochemical transformations such as carboxylation, hydroxylation, peroxidation, or modulation of signal transduction pathways such as Nuclear factor-κB (NF-κB), Mitogen-activated protein kinase (MAPK) cascade, phosphoinositide-3-kinase, nuclear factor erythroid 2–related factor 2 (Nrf2) and other processes. Increased levels of ROS/RNS, generated from both endogenous (mitochondria, NADPH oxidases) and/or exogenous sources (radiation, certain drugs, foods, cigarette smoking, pollution) result in a harmful condition termed oxidative stress (“bad stress”). Although it is widely accepted, that many chronic diseases are multifactorial in origin, they share oxidative stress as a common denominator. Here we review the importance of oxidative stress and the mechanisms through which oxidative stress contributes to the pathological states of an organism. Attention is focused on the chemistry of ROS and RNS (e.g. superoxide radical, hydrogen peroxide, hydroxyl radicals, peroxyl radicals, nitric oxide, peroxynitrite), and their role in oxidative damage of DNA, proteins, and membrane lipids. Quantitative and qualitative assessment of oxidative stress biomarkers is also discussed. Oxidative stress contributes to the pathology of cancer, cardiovascular diseases, diabetes, neurological disorders (Alzheimer’s and Parkinson’s diseases, Down syndrome), psychiatric diseases (depression, schizophrenia, bipolar disorder), renal disease, lung disease (chronic pulmonary obstruction, lung cancer), and aging. The concerted action of antioxidants to ameliorate the harmful effect of oxidative stress is achieved by antioxidant enzymes (Superoxide dismutases-SODs, catalase, glutathione peroxidase-GPx), and small molecular weight antioxidants (vitamins C and E, flavonoids, carotenoids, melatonin, ergothioneine, and others). Perhaps one of the most effective low molecular weight antioxidants is vitamin E, the first line of defense against the peroxidation of lipids. A promising approach appears to be the use of certain antioxidants (e.g. flavonoids), showing weak prooxidant properties that may boost cellular antioxidant systems and thus act as preventive anticancer agents. Redox metal-based enzyme mimetic compounds as potential pharmaceutical interventions and sirtuins as promising therapeutic targets for age-related diseases and anti-aging strategies are discussed.

show abstract

Section: Oxidative Stress Diseases Aging and Antioxidant Interventionsmentioning

confidence: 99%

Reactive oxygen species, toxicity, oxidative stress, and antioxidants: chronic diseases and aging

Jomova,

Raptova,

Alomar

et al. 2023

Arch Toxicol

363

View full text Add to dashboard Cite

show abstract

“…Magnolia bark, derived from the Magnolia tree, is multifunctional due to the presence of two active pharmacological ingredients (APIs), Magnolol and Honokiol [ 12 ]. Various properties of Magnolia Bark have been determined, such as anti-inflammatory, antimicrobial, antioxidant, neuroprotective and cytotoxic activity [ 13 ]. Honokiol has been suggested to regulate cell signalling, proliferation and growth inhibition in various tumors, but has also shown efficacy as an adjuvant agent alongside standard chemotherapeutics and radiotherapy to overcome drug resistance [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Traditional Plant-Derived Compounds Inhibit Cell Migration and Induce Novel Cytoskeletal Effects in Glioblastoma Cells

Thompson,

Prior,

Brüning-Richardson

2024

JoX

View full text Add to dashboard Cite

Glioblastomas (GBMs) are aggressive and invasive cancers of the brain, associated with high rates of tumour recurrence and poor patient outcomes despite initial treatment. Targeting cell migration is therefore of interest in highly invasive cancers such as GBMs, to prevent tumour dissemination and regrowth. One current aim of GBM research focuses on assessing the anti-migratory properties of novel or repurposed inhibitors, including plant-based drugs which display anti-cancer properties. We investigated the potential anti-migratory activity of plant-based products with known cytotoxic effects in cancers, using a range of two-dimensional (2D) and three-dimensional (3D) migration and invasion assays as well as immunofluorescence microscopy to determine the specific anti-migratory and phenotypic effects of three plant-derived compounds, Turmeric, Indigo and Magnolia bark, on established glioma cell lines. Migrastatic activity was observed in all three drugs, with Turmeric exerting the most inhibitory effect on GBM cell migration into scratches and from the spheroid edge at all the timepoints investigated (p < 0.001). We also observed novel cytoskeletal phenotypes affecting actin and the focal adhesion dynamics. As our in vitro results determined that Turmeric, Indigo and Magnolia are promising migrastatic drugs, we suggest additional experimentation at the whole organism level to further validate these novel findings.

show abstract

“…Honokiol (HNK) is a small biphenyl lignan with biological activity extracted from the bark of Magnolia officinalis or other species of Magnoliaceae (Wu W & Xu, 2021). Applying HNK has demonstrated antiangiogenic, anti-inflammatory, antioxidative, antiviral, neurological effect, and antitumor activity in clinical studies, while safety and toxicology of HNK have revealed no detectable toxicity (Sarrica et al., 2018 ; Khatoon et al., 2022 ). Among these, its antitumor properties have garnered considerable research interest.…”

Section: Introductionmentioning

confidence: 99%

Polysialic acid-functionalized liposomes for efficient honokiol delivery to inhibit breast cancer growth and metastasis

Guan

et al. 2023

Drug Delivery

View full text Add to dashboard Cite

To improve the anti-metastasis effects of honokiol (HNK) on breast cancer, we designed cationic liposomes (Lip) in which HNK was encapsulated into Lip, and its surface was modified with negatively charged polysialic acid (PSA-Lip-HNK) for efficient treatment of breast cancer. PSA-Lip-HNK possessed a homogeneous spherical shape and high encapsulation efficiency. In vitro 4T1 cell experiments indicated that PSA-Lip-HNK increased cellular uptake and cytotoxicity via the endocytosis pathway mediated by PSA and selectin receptors. Furthermore, the significant antitumor metastasis impact of PSA-Lip-HNK was confirmed by wound healing and cell migration and invasion. Enhanced in vivo tumor accumulation of the PSA-Lip-HNK was observed in 4T1 tumor-bearing mice by living fluorescence imaging. For in vivo antitumor experiments using 4T1 tumor-bearing mice, PSA-Lip-HNK exhibited a higher tumor growth and metastasis inhibition compared with unmodified liposomes. Therefore, we believe that PSA-Lip-HNK well combined biocompatible PSA nano-delivery and chemotherapy, providing a promising drug delivery approach for metastatic breast cancer therapy.

show abstract

Pharmacological features, health benefits and clinical implications of honokiol

Cited by 22 publications

References 248 publications

Reactive oxygen species, toxicity, oxidative stress, and antioxidants: chronic diseases and aging

Reactive oxygen species, toxicity, oxidative stress, and antioxidants: chronic diseases and aging

Traditional Plant-Derived Compounds Inhibit Cell Migration and Induce Novel Cytoskeletal Effects in Glioblastoma Cells

Polysialic acid-functionalized liposomes for efficient honokiol delivery to inhibit breast cancer growth and metastasis

Contact Info

Product

Resources

About