Pharmacological evidences for cytotoxic and antitumor properties of Boswellic acids from Boswellia serrata

Khan, Mohammad Ahmed; Ali, Rahmat; Parveen, Rabea; Najmi, Abul Kalam; Ahmad, Sayeed

doi:10.1016/j.jep.2016.06.053

Cited by 58 publications

(41 citation statements)

References 67 publications

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“…To evaluate the possible biological effects of these different formulations, extracts A and G, normalized on the basis of AKBA content, were used for in vitro analyses to assess cytotoxicity, anti-inflammatory activity, and angiogenic properties in comparison with pure BAs. Cytotoxic effects of B. serrata dry extracts and BAs were reported in several studies in different cancer cell lines, such as leukemia cells, prostate cancer cells, and gastrointestinal cancer cells [ 7 , 27 – 30 ]. As regards the biochemical mechanism of cell death, Liu et al [ 31 ] reported that BAs are able to induce apoptosis in Hep-G2 cells through the activation of caspase-8, while Bhushan et al [ 32 ] found that a triterpendiol derived from BAs induced apoptosis in HL-60 cells through the activation of Bcl-2 and caspase-3.…”

Section: Discussionmentioning

confidence: 99%

Anti‐Inflammatory Activity of Boswellia serrata Extracts: An In Vitro Study on Porcine Aortic Endothelial Cells

Bertocchi

Isani

Medici

et al. 2018

Oxidative Medicine and Cellular Longevity

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This study is aimed at investigating the cytotoxicity, anti-inflammatory, and angiogenic activities of two Boswellia serrata extracts on primary culture of porcine aortic endothelial cells (pAECs). Chemical characterization of a dry extract (extract A) and a hydroenzymatic extract (extract G) of B. serrata was performed by HPLC using pure boswellic acids (BAs) as standard. In cultured pAECs, extract G improved cell viability, following LPS challenge, in a dose-dependent manner and did not show any toxic effect. On the other hand, extract A was toxic at higher doses and restored pAEC viability after LPS challenge only at lower doses. Pure BAs, used at the same concentrations as those determined in the phytoextracts, did not contrast LPS-induced cytotoxicity. Extract A showed proangiogenic properties at the lowest dose, and the same result was observed using pure AKBA at the corresponding concentration, whereas extract G did not show any effect on the migration capacity of endothelial cells. In conclusion, an anti-inflammatory activity of B. serrata extracts on endothelial cells was reported, though cytotoxicity or proliferative stimulation can occur instead of a protective effect, depending on the dose and the formulation.

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Section: Discussionmentioning

confidence: 99%

Anti‐Inflammatory Activity of Boswellia serrata Extracts: An In Vitro Study on Porcine Aortic Endothelial Cells

Bertocchi

Isani

Medici

et al. 2018

Oxidative Medicine and Cellular Longevity

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“…Frankincense oleo-gum resins have been used in traditional medicine to treat a variety of inflammatory conditions, including arthritis, colitis, and asthma [ 58 , 59 ]. Boswellic acids, including β-boswellic acid, 11-keto-β-boswellic acid, and acetyl-11-keto-β-boswellic acid, have been implicated in the anti-inflammatory properties of Boswellia resins; these triterpenoid components are involved in inhibition of 5-lipoxygenase (5-LOX), inducible nitric oxide synthase (iNOS), cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) [ 60 ].…”

Section: Resultsmentioning

confidence: 99%

“…Frankincense has been used in the Indian traditional medicine (Ayurveda) and in Traditional Chinese Medicine (TCM) as a treatment for proliferative diseases [ 78 ]. In addition, extracts of frankincense oleo-gum resins have shown in-vitro cytotoxic activity on several human tumor-derived cell lines [ 58 , 79 , 80 , 81 ], and these activities have been attributed to boswellic acids [ 82 ]. Interestingly, although β-boswellic acid [ 83 ] and 3-acetyl-11-keto-β-boswellic acid [ 84 ] have shown antineoplastic activities, this reverse-docking study did not reveal particularly notable docking properties to cancer-relevant protein targets.…”

Section: Resultsmentioning

confidence: 99%

Protein Targets of Frankincense: A Reverse Docking Analysis of Terpenoids from Boswellia Oleo-Gum Resins

Byler

Setzer

2018

Medicines

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Background: Frankincense, the oleo-gum resin of Boswellia trees, has been used in traditional medicine since ancient times. Frankincense has been used to treat wounds and skin infections, inflammatory diseases, dementia, and various other conditions. However, in many cases, the biomolecular targets for frankincense components are not well established. Methods: In this work, we have carried out a reverse docking study of Boswellia diterpenoids and triterpenoids with a library of 16034 potential druggable target proteins. Results: Boswellia diterpenoids showed selective docking to acetylcholinesterase, several bacterial target proteins, and HIV-1 reverse transcriptase. Boswellia triterpenoids targeted the cancer-relevant proteins (poly(ADP-ribose) polymerase-1, tankyrase, and folate receptor β), inflammation-relevant proteins (phospholipase A2, epoxide hydrolase, and fibroblast collagenase), and the diabetes target 11β-hydroxysteroid dehydrogenase. Conclusions: The preferential docking of Boswellia terpenoids is consistent with the traditional uses and the established biological activities of frankincense.

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“…Auf der anderen Seite werden in verschiedenen Übersich-ten Boswelliasäuren immer wieder als potenzielle Kandidaten zur Behandlung von Tumoren benannt, so z. B. in [53,54].…”

Section: üBertragbarkeit Der In-vitro-ergebnisse Auf Den Menschenunclassified

Boswelliaextrakte/Boswelliasäuren bei malignen Tumoren: Eine Übersicht

Ammon¹

2019

DZO

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ZusammenfassungHarze der Bäume verschiedener Boswellia-Spezies – pharmazeutisch Olibanum genannt – werden seit Jahrtausenden als Arzneimittel – auch bei Tumoren – verwendet. Seit den 1990er-Jahren häufen sich die Berichte über Antitumorwirkungen von Extrakten aus dem Harz und einigen Inhaltsstoffen, hier insbesondere von Boswelliasäuren. Präklinische Studien zeigten eine Hemmung der Proliferation, Antiangiogenese und der Ausbreitung von Metastasen sowie Induktion von Apoptose bei einer Vielzahl von Tumorzelllinien wie: Leukämie-, Glioblastom-, Meningiom-, Prostata-, Leber-, Mamma-, Kolon-, Pankreas- und Lungenkarzinomzellen.Die Inhaltsstoffe eines Boswelia-Extraktes (BE) verhalten sich in ihrer Antitumorwirkung synergistisch zueinander und auch gegenüber Chemotherapeutika und Bestrahlung. Der Mechanismus der Antitumorwirkung beeinflusst mehrere Transduktionssignalwege und Einzelfaktoren, die mit Proliferation, Apoptose, Angiogenese und Invasion im Zusammenhang stehen. Ihre Aktivierung erfolgt in vielen Fällen durch Phosphorylierungsreaktionen. Letztere werden durch BE und -inhaltsstoffe gehemmt. Eine wichtige Rolle bei der Apoptosewirkung spielt die Aktivierung von Caspasen.Klinische Studien liegen außer bei Hirntumoren nicht vor. Ein Vorteil von BE ist die geringe Toxizität. Dies sollte Anlass zur Durchführung klinischer Studien sein.

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Pharmacological evidences for cytotoxic and antitumor properties of Boswellic acids from Boswellia serrata

Cited by 58 publications

References 67 publications

Anti‐Inflammatory Activity of Boswellia serrata Extracts: An In Vitro Study on Porcine Aortic Endothelial Cells

Anti‐Inflammatory Activity of Boswellia serrata Extracts: An In Vitro Study on Porcine Aortic Endothelial Cells

Protein Targets of Frankincense: A Reverse Docking Analysis of Terpenoids from Boswellia Oleo-Gum Resins

Boswelliaextrakte/Boswelliasäuren bei malignen Tumoren: Eine Übersicht

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