Pharmacological evaluation of the anxiolytic-like effects of an aqueous extract of the Raphanus sativus L. sprouts in mice

Antinociceptive effects of Raphanus sativus sprouts involve the opioid and 5-HT1A serotonin receptors, cAMP/cGMP pathways, and the central activity of sulforaphane

“…Chemical analysis of this aqueous extract of R. sativus sprouts allowed us to identify and quantify a significant presence of sulforaphane (2500 μM), sulforaphane (SFN, 15 μM), iberin (0.75 μM), and indole-3-carbinol (0.75 μM). 18…”

“…of 500 mg kg −1 , already reported for its significant depressant effects on the CNS. 18 Distilled water was used as a vehicle. All the drugs were administered in a volume of 0.1 mL per 10 g body weight (b.w.)…”

“…11 Furthermore, it has been reported as antimicrobial, 12,13 anticancer, 14 antioxidant 15,16 and anxiolytic. 17,18 . A preliminary study of the aqueous extract of Raphanus sativus cv.…”

“…Sango sprouts as an anxiolytic supports its CNS activity. 18 Nevertheless, its pharmacological effects on pain relief have not been described, nor its antinociceptive activity or a possible mechanism of action. Therefore, the purpose of this study is to provide preclinical information regarding the pharmacological effects of this aqueous extract in a nociceptive pain model by analyzing the possible gastric damage caused by the most common analgesic drugs and a possible mechanism of action at peripheral and central levels.…”