Pharmacological Evaluation of Different Extracts of Forsskaolea tenacissima

Sher, Alam; Afzal, Masood; Bakht, Jehan

doi:10.4172/pharmaceutical-sciences.1000224

Cited by 4 publications

(2 citation statements)

References 17 publications

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“…This method is called solvent-solvent fractionation. The crude methanolic fraction obtained in the first phase and n-butanol fraction in the last were used for further activities described in this work [32].…”

Section: Extraction and Fractionationmentioning

confidence: 99%

Extraction and Fractionation of Prokinetic Phytochemicals from Chrozophora tinctoria and Their Bioactivities

et al. 2022

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Chrozophora tinctoria is an annual plant of the family Euphorbiaceae, traditionally used as a laxative, a cathartic and an emetic. A methanolic extract of Chrozophora tinctoria (MEC) whole plant and an n-butanol fraction of Chrozophora tinctoria (NBFC) were analyzed by gas chromatography–mass spectrometry (GC-MS) to detect the phytochemicals. MEC and NBFC were tested for in vitro anti acetylcholinesterase (AChE) potential. The effect of both samples on intestinal propulsive movement and spasmolytic activity in the gastrointestinal tract (GIT) was also studied. About twelve compounds in MEC and three compounds in NBFC were tentatively identified through GC-MS. Some of them are compounds with known therapeutic activity, such as toluene; imipramine; undecane; 14-methyl-pentadecanoic acid methyl ester; and hexadecanoic acid. Both NBFC and MEC samples were checked for acute toxicity and were found to be highly toxic in a dose-dependent manner, causing diarrhea and emesis at 1 g/kg concentration in pigeons, with the highest lethargy and mortality above 3 g/kg. Both the samples of Chrozophora tinctoria revealed significant (p ≤ 0.01) laxative activity against metronidazole (7 mg/kg) and loperamide hydrochloride (4 mg/kg)-induced constipation. NBFC (81.18 ± 2.5%) and MEC (68.28 ± 2.4%) significantly increased charcoal meal intestinal transit compared to distal water (41.15 ± 4.3%). NBFC exhibited a significant relaxant effect (EC50 = 3.40 ± 0.20 mg/mL) in spontaneous rabbit jejunum as compared to MEC (EC50 = 4.34 ± 0.68 mg/kg). Similarly, the impact of NBFC on KCl-induced contraction was more significant than that of MEC (EC50 values of 7.22 ± 0.06 mg/mL and 7.47 ± 0.57 mg/mL, respectively). The present study scientifically validates the folk use of Chrozophora tinctoria in the management of gastrointestinal diseases such as constipation. Further work is needed to isolate the phytochemicals that act as diarrheal agents in Chrozophora tinctoria.

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Section: Extraction and Fractionationmentioning

confidence: 99%

Extraction and Fractionation of Prokinetic Phytochemicals from Chrozophora tinctoria and Their Bioactivities

et al. 2022

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“…Forsskaolea tenacissima L. has been used in folk medicine in Pakistan as anti-inflammatory, antispasmodic, antidiabetic and antipyretic [7]. It also showed antioxidant [8], hepatoprotective [9], antinociceptive, antipyretic [10], antiviral and antibacterial activities [11]. Moreover, the preliminary phytochemical screening of aerial parts of F. tenacissima L. showed the presence of sterols, triterpenes and polyphenolics such as flavonoids & tannins, in addition to the isolation of sterols such as…”

Section: Introductionmentioning

confidence: 99%

Promising Antidiabetic and Wound Healing Activities of Forsskaolea tenacissima L. Aerial Parts.

Assaf

Nafady

Allam

et al. 2019

Journal of advanced Biomedical and Pharmaceutical Sciences

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The aim of present study was to evaluate the antidiabetic activity of the total methanolic extract (TME) and different fractions of Forsskaolea tenacissima L. aerial parts with alloxan-induced diabetic rats and estimate its wound healing activity by excision wound model in rats as well as determine its toxicological activity by lethal dose 50 % (LD 50 ). The ethyl acetate fraction showed a significant decrease in blood glucose level (36.00 %, P < 0.001) in comparison with glibenclamide (36.14 %, P < 0.001) as standard. The TME group showed marked increase in wound healing activity (97.9 %) compared with gentamycin standard group (96.8 %). The TME is considered safe due to its LD 50 , which was 7 g/kg body weight.

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Phytochemical profile and pharmacological potential of Withania somnifera whole plant extracts

Sher,

Iqbal,

Adil

et al. 2024

Biomedical Chromatography

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Withania somnifera belongs to the family Solanaceae, commonly called ashwagandha, and is traditionally used as an astringent, hepatoprotective and antioxidant, and as a treatment for rheumatism. Therefore the current study aimed to explore the dichloromethane fraction of W. somnifera whole plant (DCFWS) and ethyl acetate fraction of W. somnifera (EAFWS) using gas chromatoghraphy–mass spectrometry (GC–MS) analysis and to find the acetylcholinesterase inhibition potential along with spasmolytic activity. The GC–MS‐detected phytochemicals were 2,4‐bis(1,1‐dimethylethyl), hexadecanoic acid, 1‐nonadecene and 11‐octadecenoic acid. The DCFWS and EAFWS exhibited acetylcholinesterase inhibitory potential with significant inhibitory concentration values. The acute toxicity results of both fractions showed high toxicity, causing emesis at 0.5 g and both emesis and diarrhea at 1 g/kg. Both fractions exhibited significant (p ≤ 0.01) laxative activity against metronidazole (7 mg/kg) and loperamide hydrochloride (4 mg/kg) induced constipation. Both DCFWS (66.8 ± 3.85%) and EAFWS (58.58 ± 3.28%) significantly (p ≤ 0.05) increased charcoal movement compared with distal water (43.93 ± 4.34%). Similarly the effect of DCFWS on KCl‐induced (80 mm) contraction was more significant as compared with EAFWS. It was concluded that the plant can be used in the treatment of gastrointestinal tract diseases such as constipation. Furthermore, additional work is required in the future to determine the bioactive compounds that act as therapeutic agents in W. somnifera.

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Pharmacological Evaluation of Different Extracts of Forsskaolea tenacissima

Cited by 4 publications

References 17 publications

Extraction and Fractionation of Prokinetic Phytochemicals from Chrozophora tinctoria and Their Bioactivities

Extraction and Fractionation of Prokinetic Phytochemicals from Chrozophora tinctoria and Their Bioactivities

Promising Antidiabetic and Wound Healing Activities of Forsskaolea tenacissima L. Aerial Parts.

Phytochemical profile and pharmacological potential of Withania somnifera whole plant extracts

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