Pharmacological evaluation of Alstonia scholaris: Anti-inflammatory and analgesic effects

Shang, Jian Ku; Cai, Xiang‐Hai; Feng, Tao; Zhao, Yun‐Li; Wang, Jingkun; Zhang, Luyong; Yan, Ming; Luo, Xiao‐Dong

doi:10.1016/j.jep.2010.02.011

Cited by 153 publications

(92 citation statements)

References 24 publications

(19 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Members of the genus Alstonia produce a range of picrinine (Hai et al, 2008) and picraline (Arai et al, 2010) derivatives that include powerful N-methylated drug candidates that inhibit the Na + -Glc cotransporter involved in the reabsorption of Glc in human kidneys. In addition, picrinine from Alstonia scholaris (Chatterjee et al, 1965) has been documented to have powerful antitussive, antiasthmatic, and expectorant properties (Shang et al, 2010). We conclude that the many N-methylated derivatives of picrinine found in nature are likely to involve the new PiNMT genes described in this study.…”

Section: Discussionmentioning

confidence: 53%

A Picrinine N-Methyltransferase Belongs to a New Family of γ-Tocopherol-Like Methyltransferases Found in Medicinal Plants That Make Biologically Active Monoterpenoid Indole Alkaloids

Levac

Cázares

et al. 2016

Plant Physiol.

View full text Add to dashboard Cite

Members of the Apocynaceae plant family produce a large number of monoterpenoid indole alkaloids (MIAs) with different substitution patterns that are responsible for their various biological activities. A novel N-methyltransferase involved in the vindoline pathway in Catharanthus roseus showing distinct similarity to g-tocopherol C-methyltransferases was used in a bioinformatic screen of transcriptomes from Vinca minor, Rauvolfia serpentina, and C. roseus to identify 10 g-tocopherol-like N-methyltransferases from a large annotated transcriptome database of different MIA-producing plant species (www.phytometasyn.ca). The biochemical function of two members of this group cloned from V. minor (VmPiNMT) and R. serpentina (RsPiNMT) have been characterized by screening their biochemical activities against potential MIA substrates harvested from the leaf surfaces of MIA-accumulating plants. The approach was validated by identifying the MIA picrinine from leaf surfaces of Amsonia hubrichtii as a substrate of VmPiNMT and RsPiNMT. Recombinant proteins were shown to have high substrate specificity and affinity for picrinine, converting it to N-methylpicrinine (ervincine). Developmental studies with V. minor and R. serpentina showed that RsPiNMT and VmPiNMT gene expression and biochemical activities were highest in younger leaf tissues. The assembly of at least 150 known N-methylated MIAs within members of the Apocynaceae family may have occurred as a result of the evolution of the g-tocopherol-like N-methyltransferase family from g-tocopherol methyltransferases.

show abstract

Section: Discussionmentioning

confidence: 53%

A Picrinine N-Methyltransferase Belongs to a New Family of γ-Tocopherol-Like Methyltransferases Found in Medicinal Plants That Make Biologically Active Monoterpenoid Indole Alkaloids

Levac

Cázares

et al. 2016

Plant Physiol.

View full text Add to dashboard Cite

show abstract

“…Similarly, total flavonoid content was 5 to 8 folds higher in other extracts than the AEAS. Presence of high flavonoid and phenolic compounds in ethanolic leaf extract of A. scholaris has therapeutic importance (Sinnathambi et al, 2010;Shang et al, 2010;Subraya et al, 2012) besides its potential use in the food industry as natural antioxidant from plant origin. The efficiency of antioxidant potential of different extracts depends on its ability to scavenge free radicals either by donating hydrogen atom to the oxidizing free radical or to decrease the energy of the antioxidant radical that prevents the autoxidation of the antioxidant radical into additional free radicals.…”

Section: Resultsmentioning

confidence: 99%

Polyphenolic constituents and antioxidant/antiradical activity in different extracts of Alstonia scholaris (Linn.)

Verma¹,

Raina²,

Sultana³

et al. 2015

Afr. J. Biotechnol.

View full text Add to dashboard Cite

Alstonia scholaris (Linn.) leaves extracted in aqueous, dichloromethane (DCM), methanolic and ethanolic solvents were assessed for different polyphenolic constituents endowed with antioxidant/antiradical activity. Total phenolic, flavonoids and tannin contents were significantly (P<0.05) higher in ethanolic extract as compared to other extracts. The antiradical activity and efficiency was significantly (P<0.05) higher in ethanolic extract followed by methanolic, DCM and aqueous extracts. The ethanolic extract as compared to other extracts also exhibited high total antioxidant capacity, superoxide and nitric oxide anion scavenging activity. However, aqueous extract has shown high hydroxyl radicals scavenging activity as compared to other extracts. Total phenolic content of the ethanolic extract of A. scholaris was positively correlated with total antioxidant capacity (r = 0.901), antiradical activity (r = 0.948) and antiradical efficiency (r = 0.891). Therefore, ethanolic extract showed maximum, contents endowed with high total antioxidant capacity, superoxide and nitric oxide radicals scavenging activity as compared to other solvents. Thus, the dietary supplementation of ethanolic extract may provide protection in preventing the free radicals induced damage besides improve the food quality by retarding oxidative degeneration of food lipids.

show abstract

“…Alstonia scholaris is known to possess hepatoprotective activity [10] , anti diabetic and anti hyperlipidemic activity [11] , antibacterial activity [12] , anticancer activity [13] , antiasthmatic and expectorant activity [14] and antidiarrhoel and spasmolytic activity. [15] The methanolic extract of the leaves possess antiplasmodial activity.…”

Section: World Journal Of Pharmacy and Pharmaceutical Sciences Other mentioning

confidence: 99%

A Review on Nootropic Effects of Saptparna

Tripathi¹

2017

WJPPS

View full text Add to dashboard Cite

Nature has gifted our planet with abundance of medicinal plants wealth that are cherished with several useful pharmacological properties. Each and every plant has some medicinal property in one or the other way, only we have to know and explore their uses in particular doses and conditions. There are lots of herbs, which are not much studied scientifically though they are used for some ornamental or other purposes like Alstonia scholaris or Saptaparna. The herb has plenty of medicinal values that boost up brain mechanism and can be used in brain disorders. They are anti inflammatory, anti oxidant and free radical scavenging, immune-stimulating and anti choline esterase. In the present review, the researches related with nootropic effect of Alstonia scholaris has been enlightened.

show abstract

Pharmacological evaluation of Alstonia scholaris: Anti-inflammatory and analgesic effects

Cited by 153 publications

References 24 publications

A Picrinine N-Methyltransferase Belongs to a New Family of γ-Tocopherol-Like Methyltransferases Found in Medicinal Plants That Make Biologically Active Monoterpenoid Indole Alkaloids

A Picrinine N-Methyltransferase Belongs to a New Family of γ-Tocopherol-Like Methyltransferases Found in Medicinal Plants That Make Biologically Active Monoterpenoid Indole Alkaloids

Polyphenolic constituents and antioxidant/antiradical activity in different extracts of Alstonia scholaris (Linn.)

A Review on Nootropic Effects of Saptparna

Contact Info

Product

Resources

About