Pharmacological Efficacy Ferulopsis Hystrix (Bunge) Pimenov of Dry Extract in Experimental of Indomethacin-Induced Gastropathy

Coumarins of Ferulopsis hystrix: LC–MS Profiling and Gastroprotective and Antioxidant Activities of Skimmin and Peucenidin

“…The F. hystrix extract reduces the platelet aggregation rate, increases bleeding time, prevents thrombosis, has an analgesic and antispasmodic action, stimulates motor-evacuation gastrointestinal tract activity, and it exhibits choleretic activity by increasing the rate of bile secretion, stimulating cholates via bile synthesis and excretion, as well as cholesterol and bilirubin excretion [32]. In vitro, the studied extract inhibits lipid peroxidation (stabilizing the structural and functional In animal experiments, F. hystrix root extract (in a dose of 100-300 mg/kg) has been found to have a gastroprotective effect against ethanol, steroid, neurogenic, and indomethacin gastropathy, and it can prevent damage to the gastric mucosa (according to Shay); this effect was achieved by increasing the resistance of the gastric mucosa to the action of aggressive factors, and by preventing the development of dystrophic and necrotic processes, as well as microcirculation disorders and inflammatory reactions, in the stomach walls of white rats [27][28][29][30]. The F. hystrix extract exhibits an anti-exudative effect (by reducing the exudation degree induced by carrageenan and formalin) and an anti-alterative effect (by limiting tissue damage caused by phlogogenic agents and accelerating the reparative regeneration processes) [31].…”

“…In vivo, it reduces the malonic dialdehyde (MDA) content and increases the antioxidant's enzyme activity [33,34].…”