Pharmacological effects of yokukansan on behavioral and psychological symptoms of dementia

Egashira, Nobuaki; Iwasaki, Katsunori

doi:10.1002/tkm2.1226

Cited by 2 publications

(1 citation statement)

References 76 publications

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“…The mechanisms underlying the effects of YKS on these positive symptoms have been extensively examined in cellular, animal, and pharmacokinetic experiments. As reviewed previously [69–72], it has been revealed that YKS modulates many neuronal pathways including serotonergic, glutamatergic, GABAergic, and other neurotransmitter pathways in CNS. The most well‐characterized targets of YKS in treating positive psychiatric symptoms are the serotonergic and glutamatergic pathways.…”

Section: Basic Studies On Yksmentioning

confidence: 99%

A review of frequently used Kampo prescriptions. Part 3. Yokukansan

Yamaguchi,

Yoshino,

Oizumi

et al. 2023

Traditional & Kampo Medicine

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BackgroundThe source of yokukansan (YKS) is thought to be Baoying‐Jinjiang (Hoeikinkyōroku in Japanese) by Xue Ji. YKS was originally designed for children and indicated for spasms, clenching of teeth, digestive dysfunction due to mental instability, and insomnia.Key FindingsYKS formula consists of seven types of crude drugs. Clinical studies have revealed that YKS exerts physiological effects including the treatment of behavioral and psychiatric symptoms of dementia (BPSD), preoperative sedation and anxiety, and postoperative delirium. A meta‐analysis showed that YKS could improve BPSD and daily living activities; however, no improvement in cognitive function was observed. Preclinical studies have also reported that YKS modulates neuronal pathways in the central nervous system, including the serotonergic, glutamatergic, GABAergic, and other neurotransmitter pathways. The incidence of adverse events associated with YKS was 5.17%, with the major adverse effect being pseudoaldosteronism. Routine blood sampling is considered for hypokalemia prevention.ConclusionYKS is useful for BPSD and perioperative mental instability. The modulation of the serotonergic and glutamatergic neural pathways is one of mechanisms. Pseudoaldosteronism is one of the side effects.

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Section: Basic Studies On Yksmentioning

confidence: 99%

A review of frequently used Kampo prescriptions. Part 3. Yokukansan

Yamaguchi,

Yoshino,

Oizumi

et al. 2023

Traditional & Kampo Medicine

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Effectiveness of Japanese traditional medicine yokukansan for nocturia due to sleep disorders

Matsuo,

Mori,

Honda

et al. 2024

Traditional & Kampo Medicine

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AimTo evaluate the effectiveness of yokukansan, a traditional Japanese medicine, as treatment for nocturia due to sleep disorders.MethodsIn this study, we included patients diagnosed with nocturia due to sleep disorders, evaluated using the Pittsburgh Sleep Quality Index (PSQI). Participants received 2.5 g of yokukansan, three times daily, for 12 weeks. We evaluated the changes in the overactive bladder (OAB) symptom score (OABSS), hours of undisturbed sleep (HUS), and PSQI score. In addition, patients were categorized based on the severity of their sleep disorders, and we divided patients into two groups according to whether the severity of the disorder was downgraded after treatment: the improved and unchanged groups.ResultsAmong 35 patients with a mean ± standard deviation age of 73.2 ± 10.5 years, yokukansan administration was associated with significant improvements in nighttime urinary frequency (from 3.8 ± 2.1 to 2.1 ± 1.9), total OABSS score (from 4.9 ± 1.8 to 2.9 ± 1.9), OABSS urgency score (from 1.3 ± 1.0 to 0.7 ± 0.9), HUS (from 2.2 ± 0.6 to 3.5 ± 1.1 h), and global PSQI score (from 11.9 ± 3.1 to 10.0 ± 1.4; all p < 0.001). In addition, significant improvements were noted in both the improved and unchanged groups in terms of the total OABSS, nocturia, and urgency scores. Furthermore, yokukansan treatment was related to improved global PSQI scores in both groups (improved group: from 10.8 ± 0.7 to 8.6 ± 0.5, p = 0.001; unchanged group: from 12.3 ± 3.4 to 10.4 ± 1.3, p = 0.004).ConclusionYokukansan may effectively ameliorate nocturia due to sleep disorders.

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Pharmacological effects of yokukansan on behavioral and psychological symptoms of dementia

Cited by 2 publications

References 76 publications

A review of frequently used Kampo prescriptions. Part 3. Yokukansan

A review of frequently used Kampo prescriptions. Part 3. Yokukansan

Effectiveness of Japanese traditional medicine yokukansan for nocturia due to sleep disorders

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