Pharmacological effects of Vitamin C &amp; E on Diclofenac Sodium intoxicated Rats

El‐Shafei, Reham A.; Saleh, Rasha M.

doi:10.1016/j.biopha.2016.09.005

Cited by 25 publications

(16 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…El-shafei and Saleh [87]. Similar findings were reported by Li et al [88] who studied the effect of vitamin C on DNA damage of mice kidney treated with arsenic.…”

Section: Discussionsupporting

confidence: 81%

Protective Effect of Cranberry Extracts against Oxidative Stress and DNA Damage Induced by Diclofenac Sodium in Kidney of Male Albino Rate

Hassan¹,

Sabry²,

Hussein³

2017

View full text Add to dashboard Cite

This work aimed to find the effect of cranberry extract (75 and 150 mg/kg•b•w) and vit. C (1 g/kg•b•w orally) on renal toxicity induced by Diclofenac sodium in male albino rats. Treated rats with diclofenac sodium with a concentration 150 mg/kg•b•w, expressed a significant increase in several parameters includes, plasma total cholesterol, LDL-cholesterol, and triglyceride as well as renal nitric oxide (NO), tumor necrosis factor-alfa (TNF-α) and TBARS. In addition, a significant reduction in renal superoxide dismutase (SOD), GSH, catalase (CAT) and plasma HDL. The present results explain that, using cranberry extract and vit. C resulted in increasing the level of GSH, CAT and SOD as well as gene expression of renal SOD, CAT and IL-22 and reduce the level of TBARs significantly which led to preventing renal tissue damage. Our results also revealed that cranberry extract can protect DNA from damage as obtained from comet essay. TM-U was elevated in DCLF treated group when compared with normal. However cranberry extract was able to reduce this elevation in dose dependant manner. Histological features in H&E taken to different groups also mirrors this findings. DCLF causes many changes in renal tissue include infiltration by inflammatory cells, attenuated glomeruli, apoptosis in tubular epithelia. Keywords

show abstract

“…El-shafei and Saleh [87]. Similar findings were reported by Li et al [88] who studied the effect of vitamin C on DNA damage of mice kidney treated with arsenic.…”

Section: Discussionsupporting

confidence: 81%

Protective Effect of Cranberry Extracts against Oxidative Stress and DNA Damage Induced by Diclofenac Sodium in Kidney of Male Albino Rate

Hassan¹,

Sabry²,

Hussein³

2017

View full text Add to dashboard Cite

show abstract

“…We also investigated the effect of the combined administration of GSE at 50 mg/kg and Vit C at 50 mg/kg during LPS-induced endotoxemia. Vit C is a potent antioxidant agent; it scavenges free radicals, superoxide, hydrogen peroxide, peroxyl, and singlet oxygen species [22] and has anti-inflammatory effect [24]. Our findings revealed that the combined treatment of GSE /Vit C was effective in almost normalizing serum creatinine, uric acid, aminotransferases, PON-1 activity, and also tissue markers of oxidative stress compared to the higher dose of GSE.…”

Section: Rosmentioning

confidence: 66%

“…Vit C blocks oxidative stress and helps organ recovery in chronic degenerative diseases [23]. Vit C has an anti-inflammatory effect; it arrests endothelial dysfunction and reduces cardiovascular diseases incidence [24]. Guo et al [25] suggested that Vit C treatment have potential protective effects on oxidative stress and many hazardous toxicants.…”

Section: Introductionmentioning

confidence: 99%

Grape Seed Extract and Vitamin C Combination Blocked LPS-Induced Multiple Organ Toxicity in Mice

Nada

El-Shamarka

Omara

et al. 2019

ROS

View full text Add to dashboard Cite

| Gram-negative bacteria mediate multiple organ damage through eliciting systemic inflammatory response and extensive oxidative stress in affected humans and animals. This study was done to evaluate the effect of grape seed extract (GSE) given alone or in combination with vitamin C (Vit C) on organ toxicity in mice treated with lipopolysaccharide (LPS). Mice received intraperitoneal injections of LPS on day 1 (4 mg/kg) and day 8 (2 mg/kg) of the study and starting from the first day were orally treated with GSE (50 and 100 mg/kg), GSE (50 mg/kg) plus Vit C (50 mg/kg) or saline (plus vehicle control) for 15 successive days. The no vehicle control group was treated with saline only. Results indicated that compared to the saline-treated group, LPS injection significantly increased alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatinine, uric acid, and decreased paraoxonase-1 (PON-1) in the serum. Moreover, LPS treatment significantly increased oxidative stress status and decreased the reduced glutathione (GSH) in the liver, kidney, and brain tissues. GSE given at doses of 50 and 100 mg/kg significantly decreased serum markers of liver and kidney tissue injury and decreased oxidative stress in the liver, kidney, and brain of LPS-treated mice. The resultant effect of combined treatment with GSE and Vit C was greater than that of GSE alone. Moreover, immunohistochemical studies of liver, kidney, and brain tissue sections were conducted. The LPS-induced intense immunohistochemical staining of tumor necrosis factor-alpha (TNF-α) and caspase-3 expression was decreased by treatment with GSE or GSE + Vit C in the following manner: Vit C + GSE > GSE 100 mg/kg > GSE 50 mg/kg. Our data indicate that the combination of GSE and Vit C can mitigate multiple organ toxicity in LPS-treated mice.

show abstract

“…Group 1: control (orally treated with 1% Tween 80 by gastric tube (0.5 ml daily /rat) according to Hassanein and El-Amir, (2017), Group 2: was daily oral intake of Ascorbic acid (V.C)100 mg/Kg BW in distilled water (El-Shafei and Saleh, 2016;Apaydin et al, 2017;Zhang et al, 2018). Groups 3 was daily orally treated with α-tocopherol (V.E)100 mg/Kg BW in corn oil (Apaydin et al, 2017), Groups 4: was daily orally TiO 2 nanoparticals (TiO 2 NP) (150 mg/kg BW) in 1% Tween 80 (Wang et al, 2007a;Hassanein and El-Amir, 2017).…”

Section: Experimental Designmentioning

confidence: 99%

Effect of Some Antioxidants on Rats Treated With Titanium Dioxide Nanoparticles

Ibrahim

Elkady

Hassanein

2019

Egypt. J. Food Sci.

View full text Add to dashboard Cite

T ITANIUM Dioxide Nanoparticles (TiO 2 NPs) is used in the production of food colorants, some nutritional supplements and many other products on large scale. Many studies stated that the TiO 2 NPs are more toxic than titanium dioxide (TiO 2) and as possibly carcinogenic to humans. The aim of study was carried out investigate on impacts of vitamin C and vitamin E on free radicals and antioxidant enzymes activities in male rats treated with TiO 2 NPs. The obtained results showed that, there were no significant (P≥0.05) differences found in red blood cells (RBC), hematocrit (Ht), hemoglobin (Hb) and platelets count (PLT) after treated with titanium dioxide nanoparticles (TiO 2 NPs) or natural antioxidants (vitamin E and C). The treatment with TiO 2 NPs alone caused significant (P≤0.05) increase in kidney and liver functions, while the oral intake of V.C and V.E or V.C+V.E reduced this increase. Also, the treatment with TiO 2 NPs increased the level of free radicals and decreased the activity of some antioxidant enzymes such as Superoxide dismutase (SOD),Glutathione-S-transferase (GST) and the content of Glutathione (GSH) in plasma. Meanwhile, V.C and V.E decreased the increased in free radicals and protected the activity of antioxidant enzymes in plasma of TiO 2 NPs-treated rats.

show abstract

Pharmacological effects of Vitamin C & E on Diclofenac Sodium intoxicated Rats

Cited by 25 publications

References 46 publications

Protective Effect of Cranberry Extracts against Oxidative Stress and DNA Damage Induced by Diclofenac Sodium in Kidney of Male Albino Rate

Protective Effect of Cranberry Extracts against Oxidative Stress and DNA Damage Induced by Diclofenac Sodium in Kidney of Male Albino Rate

Grape Seed Extract and Vitamin C Combination Blocked LPS-Induced Multiple Organ Toxicity in Mice

Effect of Some Antioxidants on Rats Treated With Titanium Dioxide Nanoparticles

Contact Info

Product

Resources

About