Pharmacological Effects of Polyphenol Phytochemicals on the JAK-STAT Signaling Pathway

Yin, Qianqian; Wang, Longyun; Yu, Haiyang; Chen, Daquan; Zhu, Wenwei; Sun, Changgang

doi:10.3389/fphar.2021.716672

Cited by 43 publications

(23 citation statements)

References 136 publications

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“…These differences may be due to bioactive components of TT supplementation [ 41 ]. TT´s muscle protective action via flavonoids, alkaloids, phenols, and saponins [ 15 , 39 ] are necessary to have an antioxidant and/or anti-inflammatory effect [ 11 , 42 ]. Therefore, in tissue injury skeletal muscle, membrane permeability would be reduced, thereby reducing the release of muscle-damaging enzymes from skeletal muscle into the blood circulation [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

6-Week Supplementation with Tribulus terrestris L. to Trained Male CrossFit® Athletes on Muscle, Inflammation, and Antioxidant Biomarkers: A Randomized, Single-Blind, Placebo-Controlled Trial

Fernández-Lázaro

Calvo

Pascual-Fernández

et al. 2022

IJERPH

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Tribulus terrestris L. (TT) ingredients have anti-inflammatory and antioxidant activities, but their effects on exercise-induced muscle damage (EIMD) in trained athletes are uncertain. The purpose of this single-blind placebo-controlled trial, in accordance with CONSORT guidelines, was to examine the effect of 6 weeks of TT supplementation on muscle metabolism, inflammation biomarkers, and oxidant status. Thirty trained male CrossFit® athletes were randomly assigned to be supplemented with 770 mg/day of TT (intervention group (IG)) or receive a placebo daily (control group (CG)) for 6 weeks. Muscle damage enzymes, inflammation biomarkers, and Total Antioxidant Status (TAS) were assessed at baseline (T1), 21 days after baseline (T2), and after 42 days (T3). Grace, a Workout of the Day, was measured in T1 and T3. Statistical significance (p< 0.05) was found between IG and CG in Lactate Dehydrogenase (LDH), C-reactive protein (CRP), and TAS levels at the end of the follow-up. Furthermore, TAS levels were significantly (p < 0.05) lower at T2 and T3 relative to baseline in the IG, also LDH and CRP increased significantly (p < 0.05) at T2 and T3 relative to baseline in the CG. No significant (p > 0.05) decreases in muscle damage or inflammation biomarkers were observed, although a slight downward trend was observed after 6 weeks for supplemented athletes. TT supplementation could attenuate the CrossFit® training program-induced oxidative stress, muscle damage, and inflammation which could be due to the natural antioxidant and anti-inflammatory properties of TT.

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Section: Discussionmentioning

confidence: 99%

6-Week Supplementation with Tribulus terrestris L. to Trained Male CrossFit® Athletes on Muscle, Inflammation, and Antioxidant Biomarkers: A Randomized, Single-Blind, Placebo-Controlled Trial

Fernández-Lázaro

Calvo

Pascual-Fernández

et al. 2022

IJERPH

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“…• Quercetin treatment with activated T cells shows blocking of IL-12induced tyrosine phosphorylation of TYK2, JAK2, STAT3, and STAT4, resulting in a decrease in IL-12-induced T-cell proliferation and Th1 differentiation (Fig. 6) [42].…”

Section: Quercetin Working Against Cancermentioning

confidence: 97%

Lung Cancer Therapy Using Naturally Occurring Products and Nanotechnology

IMAM

IMAM²,

Agarwal

et al. 2022

Innovare J Med Sci

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Lung cancer is a severe type of cancer with highest mortality rate among all cancers. Natural products such as theaflavins, quercetin, arctigenin, EGCG, curcumin, and cinnamaldehyde are quite capable anti-inflammatory and anti-cancerous agents which are able to suppress ERK-MAPK, JAK-STAT, p38, AMPK, PI3K/Akt, MAPK, mTOR, STAT3, and Wnt/β-catenin signal transduction pathways. These APIs inhibit the inflammatory and proliferator enzymes such as COX-2, caspase-3, MMP-9, MMP-2, NF-κB, p53, Bcl-xL, Bcl-2,Mcl-1, miR-210, cyclin D1, iNOS, IL-1β, TNF-α, IFN-γ, IL-6, and IL-1α. All the above properties clearly show the anti-cancerous potential, but the problems arise because of their instability at gastrointestinal tract pH. All the compounds either degrade at gastric pH or loss their cancerous potential. New generation nanoparticles such as transferosomes are quite stable at 7.4 pH and its efficacy and drug entrapment potential are better than other conventional nanoparticle systems. If these APIs are added inside the nanovesicular structure of transferosomes and then loaded in pMDI canisters such as fluorocarbon polymerization (FCP), plasma-coated canisters with a better propellant such as HFA-134a and delivered with the help of spacers can cure lungs cancer economically, efficiently with minimal side effects and it also ensures that the cancer will not reoccur.

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“…The JAK family comprises of JAK1-3 and TYK2. The STAT family has seven members, including STAT1-4, STAT5a, STAT5b, and STAT6 ( 106 ). JAK-STAT signaling is known to play a critical role in IFN-mediated inhibition of HBV replication ( 3 ).…”

Section: Role Of Hbx In the Jak-stat Pathwaymentioning

confidence: 99%

Regulation of Pattern-Recognition Receptor Signaling by HBX During Hepatitis B Virus Infection

et al. 2022

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As a small DNA virus, hepatitis B virus (HBV) plays a pivotal role in the development of various liver diseases, including hepatitis, cirrhosis, and liver cancer. Among the molecules encoded by this virus, the HBV X protein (HBX) is a viral transactivator that plays a vital role in HBV replication and virus-associated diseases. Accumulating evidence so far indicates that pattern recognition receptors (PRRs) are at the front-line of the host defense responses to restrict the virus by inducing the expression of interferons and various inflammatory factors. However, depending on HBX, the virus can control PRR signaling by modulating the expression and activity of essential molecules involved in the toll-like receptor (TLR), retinoic acid inducible gene I (RIG-I)-like receptor (RLR), and NOD-like receptor (NLR) signaling pathways, to not only facilitate HBV replication, but also promote the development of viral diseases. In this review, we provide an overview of the mechanisms that are linked to the regulation of PRR signaling mediated by HBX to inhibit innate immunity, regulation of viral propagation, virus-induced inflammation, and hepatocarcinogenesis. Given the importance of PRRs in the control of HBV replication, we propose that a comprehensive understanding of the modulation of cellular factors involved in PRR signaling induced by the viral protein may open new avenues for the treatment of HBV infection.

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Pharmacological Effects of Polyphenol Phytochemicals on the JAK-STAT Signaling Pathway

Cited by 43 publications

References 136 publications

6-Week Supplementation with Tribulus terrestris L. to Trained Male CrossFit® Athletes on Muscle, Inflammation, and Antioxidant Biomarkers: A Randomized, Single-Blind, Placebo-Controlled Trial

6-Week Supplementation with Tribulus terrestris L. to Trained Male CrossFit® Athletes on Muscle, Inflammation, and Antioxidant Biomarkers: A Randomized, Single-Blind, Placebo-Controlled Trial

Lung Cancer Therapy Using Naturally Occurring Products and Nanotechnology

Regulation of Pattern-Recognition Receptor Signaling by HBX During Hepatitis B Virus Infection

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