Pharmacological Effects of Natural Components Against Ovarian Cancer and Mechanisms

Liu, Huidi; Liu, Shulin

doi:10.1007/978-3-030-73359-9_4

Cited by 2 publications

(2 citation statements)

References 73 publications

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“…If not appropriately diagnosed early, ovarian cancer can be life-threatening and more challenging to treat at later stages [ 4 , 6 ]. Previously, traditional Chinese medicine (TCM) has been extensively applied as a promising adjunctive drug in the fight against ovarian cancer [ 7 , 8 ]. For instance, bitter lemon seeds-derived MAP 30 [ 9 ] and yew-derived Paclitaxel [ 10 ] have recently achieved safe and curative effects against ovarian cancers.…”

Section: Introductionmentioning

confidence: 99%

Effects of Laparoscopic Hyperthermic Perfusion Therapy Combined with Adjuvant Treatment of Compound Yew Capsule on Ovarian Blood Flow Parameters and Immune Function in Patients with Ovarian Cancer

Wang

Huang

2022

Evidence-Based Complementary and Alternative Medicine

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Objective. To determine the effects of laparoscopic hyperthermic perfusion therapy combined with adjuvant compound yew capsules on ovarian blood flow parameters and immune function in patients with ovarian cancer (OC). Methods. A total of 90 OC patients enrolled in our hospital between January 2019 and January 2020 were randomly distributed into the control (Con group) and experimental group (Exp group) based on the sealed envelope method. The Con group was administered laparoscopic hyperthermic perfusion therapy. On this basis, the Exp group was subjected to compound yew capsules; the ovarian blood flow parameters and immune function indexes were compared between the two groups. Results. The Exp group was reported to perform better than the Con group regarding ovarian blood flow parameters and immune indexes after treatment ( p < 0.001 ). Conclusion. Laparoscopic hyperthermic perfusion therapy combined with adjuvant compound yew capsules for patients with OC can substantially improve the clinical indexes and immune function. Furthermore, research and adequate promotion are needed to elicit the evidence beyond preclinical studies to understand the intricacies of its implementation.

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Section: Introductionmentioning

confidence: 99%

Effects of Laparoscopic Hyperthermic Perfusion Therapy Combined with Adjuvant Treatment of Compound Yew Capsule on Ovarian Blood Flow Parameters and Immune Function in Patients with Ovarian Cancer

Wang

Huang

2022

Evidence-Based Complementary and Alternative Medicine

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“…Phytochemicals can be divided into multiple groups, such as polyphenols, terpenes, alkaloids and others, and polyphenols can be classified into flavonoids (e.g., apigenin and EGCG) and no-flavonoids (e.g., resveratrol and curcumin). We previously have demonstrated the efficacy of plant materials against diseases including malignancies and the beneficial effects of these natural products could be attributed to the phytochemicals such as lignans [23,24,[83][84][85]. According to previous studies, the combination of phytochemicals with standard chemotherapeutic drugs could significantly improve cancer patient survival [86][87][88].…”

Section: Measures Against Ici Related Adverse Effects -Combined Use O...mentioning

confidence: 99%

Combined Use of Immune Checkpoint Inhibitors and Phytochemicals as a Novel Therapeutic Strategy against Cancer

Lin¹,

Wang²,

Cao³

et al. 2023

J. Cancer

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Immune checkpoint inhibitor (ICI) therapy has dramatically changed cancer treatment, opening novel opportunities to cure malignant diseases. To date, most prevalently targeted immune checkpoints are programmed cell death protein 1 (PD-1) and cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), with many others being under extensive investigations. However, according to available data, only a fraction of patients may respond to ICI therapy. Additionally, this therapy may cause severe adverse immune-related side effects, such as diarrhea, headache, muscle weakness, rash, hepatitis and leucopenia, although most of them are not fatal, they can affect the patient's treatment outcome and quality of life. On the other hand, growing evidence has shown that phytochemicals with anticancer effects may combine ICI therapy to augment the safety and effectiveness of the treatment against cancer while reducing the adverse side effects. In this review, we summarize the state of art in the various experiments and clinical application of ICIs plus phytochemicals, with a focus on their combined use as a novel therapeutic strategy to cure cancer.

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Pharmacological Effects of Natural Components Against Ovarian Cancer and Mechanisms

Cited by 2 publications

References 73 publications

Effects of Laparoscopic Hyperthermic Perfusion Therapy Combined with Adjuvant Treatment of Compound Yew Capsule on Ovarian Blood Flow Parameters and Immune Function in Patients with Ovarian Cancer

Effects of Laparoscopic Hyperthermic Perfusion Therapy Combined with Adjuvant Treatment of Compound Yew Capsule on Ovarian Blood Flow Parameters and Immune Function in Patients with Ovarian Cancer

Combined Use of Immune Checkpoint Inhibitors and Phytochemicals as a Novel Therapeutic Strategy against Cancer

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