Pharmacological effects of medicinal components of Atractylodes lancea (Thunb.) DC.

Xie, Jun; Peng, Fu; Yu, Long-Chuan; Peng, Cheng

doi:10.1186/s13020-018-0216-7

Cited by 62 publications

(49 citation statements)

References 80 publications

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“…The potential application of Chinese herbal medicine on the disease could be attributed to the anti-inflammatory properties [21, 22]. Therefore, we aimed to explore the anti-inflammatory effect of SG.…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory activities of Sigesbeckia glabrescens Makino: combined in vitro and in silico investigations

et al. 2019

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Background Sigesbeckia glabrescens Makino (SG) is one of the important plant origins of Sigesbeckiae herba and has been widely used for the treatment of chronic inflammatory diseases in China. However, the underlying anti-inflammatory mechanism of SG is rarely investigated and reported. There are more than 40 kinds of chemical constituents in SG, but the action of the bioactive compounds of SG is still unclear. Therefore, we aimed to systemically investigate the mechanisms behind the anti-inflammatory properties of SG by combining in vitro and in silico investigations. Methods Cytotoxicity was measured using the 3-[4,5-dimethyl-2-thiazolyl]-2,5-diphenyltetrazolium bromide (MTT) and lactate dehydrogenase (LDH) assays. Nitric oxide (NO) release was detected using the Griess assay. The secretion of pro-inflammatory cytokines and the expression of relevant proteins were assessed using ELISA kits and Western blots, respectively. Molecular docking was performed and scored using AutoDock via a comparison with the molecular docking of N-acetyl-d-glucosamine (NAG). Results In lipopolysaccharides (LPS)-stimulated macrophages, SG significantly inhibited NO, MCP-1, and IL-6 secretion; iNOS expression; and NF-κB activation but did not significantly affect MAPK signalling (p38, ERK, and JNK). Moreover, the results from the molecular docking prediction suggested that over 10 compounds in SG could likely target TLR4, p105, and p65. Conclusions These findings suggest that the anti-inflammatory effects of SG are highly related to the inactivation of NF-κB. Moreover, this study provides a novel approach to investigate the effects of herbal medicine using combined in vitro and in silico investigations.

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Section: Discussionmentioning

confidence: 99%

Anti-inflammatory activities of Sigesbeckia glabrescens Makino: combined in vitro and in silico investigations

et al. 2019

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“…Magnolol and honokiol are the main active ingredients in H. officinalis, which have the effects of antifungal, anti-Saprolegnia, and analgesic activity [29][30][31][32]. A. lancea is a common medicinal plant, which has antitumor, anti-inflammatory, and other essential effects [33][34][35]. Atractylone, atractylodin, hinesol, and β-eudesmol are the main active components of A. lancea [36,37].…”

Section: Introductionmentioning

confidence: 99%

Microscopic Characteristic and Chemical Composition Analysis of Three Medicinal Plants and Surface Frosts

Han

Shan

et al. 2019

Molecules

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The accumulation of chemical constituents of some medicinal plants, such as Paeonia ostii T. Hong et J. X. Zhang, Houpoëa officinalis (Rehder and E. H. Wilson) N. H. Xia and C. Y. Wu. andAtractylodes lancea (Thunb.) DC, can precipitate on the surface and form frosts after natural or artificial intervention. The characteristics of these three medicinal plants and their frosts were analyzed by light microscope, polarizing microscope, stereomicroscope, and metalloscope. The results of ordinary Raman of P. ostii and H. officinalis showed that the frosts of P. ostii matched paeonol, while that of H. officinalis matched magnolol and honokiol. In P. ostii and its frost, 19 peaks were identified by UPLC-Q/TOF-MS, and the main component was paeonol. Eleven components were identified in H. officinalis and its frosts, and the main components were magnolol and honokiol. A. lancea and its frosts were analyzed by gas chromatography-mass spectrometry (GC-MS), 21 were identified, and its main components were hinesol and β-eudesmol. These three medicinal plants accumulate compounds and precipitate frosts on the surface. The results show that the components of the frosts provide a basis for quality evaluation and research on similar medicinal plants, and reveals the scientific connotation of "taking the medicinal materials' precipitated frosts as the best" of P. ostii, H. officinalis, and A. lancea, to some extent.

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“… Jun et al, 2018 , Sakurai et al, 1994 , Xiao et al, 2002 , Yuan et al, 2009 , Zhao, 2009 , Zhu J, 2012 .…”

Section: Uncited Referencementioning

confidence: 99%

Atractylodis Rhizoma: A review of its traditional uses, phytochemistry, pharmacology, toxicology and quality control

Zhang

Zhao

Chang

et al. 2021

Journal of Ethnopharmacology

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Ethnopharmacological relevance Atractylodis Rhizoma (AR), mainly includes Atractylodes lancea (Thunb.) DC. ( A. lancea ) and Atractylodes chinensis (DC.) Koidz. ( A. chinensis ) is widely used in East Asia as a diuretic and stomachic drug, for the treatment of rheumatic diseases, digestive disorders, night blindness, and influenza as it contains a variety of sesquiterpenoids and other components of medicinal importance. Aim of the review A systematic summary on the botany, traditional uses, phytochemistry, pharmacology, toxicology, and quality control of AR was presented to explore the future therapeutic potential and scientific potential of this plant. Materials and methods A review of the literature was performed by consulting scientific databases including Google Scholar, Web of Science, Baidu Scholar, Springer, PubMed, ScienceDirect, CNKI, etc. Plant taxonomy was confirmed to the database “The Plant List”. Results Over 200 chemical compounds have been isolated from AR, notably sesquiterpenoids and alkynes. Various pharmacological activities have been demonstrated, especially improving gastrointestinal function and thus allowed to assert most of the traditional uses of AR. Conclusions The researches on AR are extensive, but gaps still remain. The molecular mechanism, structure-activity relationship, potential synergistic and antagonistic effects of these components need to be further elucidated. It is suggested that further studies should be carried out in the aspects of comprehensive evaluation of the quality of medicinal materials, understanding of the “effective forms” and “additive effects” of the pharmacodynamic substances based on the same pharmacophore of TCM, and its long-term toxicity in vivo and clinical efficacy.

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Pharmacological effects of medicinal components of Atractylodes lancea (Thunb.) DC.

Cited by 62 publications

References 80 publications

Anti-inflammatory activities of Sigesbeckia glabrescens Makino: combined in vitro and in silico investigations

Anti-inflammatory activities of Sigesbeckia glabrescens Makino: combined in vitro and in silico investigations

Microscopic Characteristic and Chemical Composition Analysis of Three Medicinal Plants and Surface Frosts

Atractylodis Rhizoma: A review of its traditional uses, phytochemistry, pharmacology, toxicology and quality control

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