Pharmacological Effects of Ephedrine

Limberger, Renata Pereira; Jacques, Ana Laura Bemvenuti; Schmitt, Gabriela Cristina; Arbo, Marcelo Dutra

doi:10.1007/978-3-642-22144-6_41

Cited by 16 publications

(8 citation statements)

References 64 publications

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“…(dehydroelsholtzia ketone) and a peculiar chemical compound of Ephedra sp. L. (ephedrine) indicated a possible intake of decoctions based on these plants, probably to treat respiratory and gastro-intestinal disorders [122][123].…”

Section: Discussionmentioning

confidence: 99%

A multidisciplinary approach for investigating dietary and medicinal habits of the Medieval population of Santa Severa (7th-15th centuries, Rome, Italy)

et al. 2020

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A multidisciplinary approach, combining stable isotope analysis from bone proteins and investigations on dental calculus using DNA analysis, light microscopy, and gas chromatography coupled with mass spectrometry, was applied to reconstruct dietary and medicinal habits of the individuals recovered in the cemetery of the Castle of Santa Severa (7 th-15 th centuries CE; Rome, Italy). Stable isotope analysis was performed on 120 humans, 41 faunal specimens and 8 charred seeds. Dental calculus analyses were carried out on 94 samples. Overall, isotope data indicated an omnivorous diet based on C 3-terrestrial protein, although some individuals possessed carbon values indicative of C 4 plant consumption. In terms of animal protein, the diet was probably based on cattle, sheep, pig and chicken products, as witnessed by the archaeozoological findings. Evidence from calculus suggested the consumption of C 3 cereals, Fabaceae, Fagaceae, milk and dairy products. Secondary metabolites of herbs and wine were also detected. The detection of marine fish ancient DNA, as well as of ω3 fatty acids in calculus, hypothesized the consumption of marine foodstuffs for this coastal population, despite the lack of a clear marine isotopic signal and the presence of polyunsaturated fatty acids in plant tissues. Moreover, the knowledge of ethnopharmacological tradition and the application of medicinal plants (e.g. Punica granatum L., Ephedra sp. L.) were also identified. The detection of artemisinin, known to have antimalarial properties, led to hypothesize the presence of malaria in the area. Altogether, the combined application of microscopy and biomolecular techniques provided an innovative reconstruction of Medieval lifeways in Central Italy.

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Section: Discussionmentioning

confidence: 99%

A multidisciplinary approach for investigating dietary and medicinal habits of the Medieval population of Santa Severa (7th-15th centuries, Rome, Italy)

et al. 2020

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“…The identification of secondary metabolites, essentially alkaloids, with pharmaceutical properties suggested the knowledge of medicinal plant species, such as Stachys officinalis (astringent, digestive and sedative) [ 125 ] and Ephedra sp. (bronchodilator) [ 126 ]. The detection of a metabolite typical of Cucurbitaceae (cucumber aldehyde) supported the use of species such as cucumber and squash; this evidence was also confirmed by the presence, in the calculus of a specimen, of a fragment of cucumber fruit epicarp [ 127 ].…”

Section: Discussionmentioning

confidence: 99%

Who were the miners of Allumiere? A multidisciplinary approach to reconstruct the osteobiography of an Italian worker community

et al. 2018

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This research presents an in-depth study of the skeletal remains collected from the archaeological site of Allumiere (15th-16th centuries CE; Rome, Italy). A multidisciplinary approach was used, combining skeletal biology, molecular anthropology and archaeobotany with the aim of reconstructing the osteobiography of the alum miners buried at the site. Since 1460, the area of the Tolfa Mountains was significant for the exploitation of alum which was used for a wide range of purposes in the Middle Ages, ranging from woven production to medical practice. A total of 70 individuals (63 adults and 7 juveniles) were studied. The sex ratio of the community indicated a higher prevalence of males with respect to females. Morphological examination indicated occupational musculoskeletal stress markers, which might reflect the specific phase of alum production that each individual was occupied in. Dietary reconstruction was primarily performed through carbon and nitrogen stable isotope analysis with integration of the results obtained by microscopic, genetic and GC-MS investigations on dental calculus. The diet was omnivorous, indicating a reliance on C3-terrestrial protein and evidence for limited C4 consumption by some individuals. Herbivores, such as sheep and cattle, appear to have contributed to the diet more than pigs and chickens. Consumption of Fagaceae and Poaceae species was predominant; moreover, indicators of Brassicaceae and milk and its derivatives were abundantly recurrent in the population, followed by plant oils and theophylline. Furthermore, the detection of pharmacological alkaloids indicated the knowledge and application of medicinal plants by the community. The novel use of multiple techniques based on cutting-edge technologies has provided a unique window on the lifestyles of individuals from one of the first Italian settlements of alum workers.

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“…Clinically, ephedra has been tested for its anti-hypertensive [203], bronchodilator [204], decongestant [205], diuretic [206] and immune booster [207]. The immunomodulatory response of ephedrine and the Ephedra extract were studied on human peripheral lymphocytes [202].…”

Section: Figure 21 Ephedrine Pseudoephedrine and Methylephedrinementioning

confidence: 99%

The Phytochemical Constitution of Maltese Medicinal Plants – Propagation, Isolation and Pharmacological Testing

Attard¹,

Attard²,

Tanti³

et al. 2015

Phytochemicals - Isolation, Characterisation and Role in Human Health

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Pharmacological Effects of Ephedrine

Cited by 16 publications

References 64 publications

A multidisciplinary approach for investigating dietary and medicinal habits of the Medieval population of Santa Severa (7th-15th centuries, Rome, Italy)

A multidisciplinary approach for investigating dietary and medicinal habits of the Medieval population of Santa Severa (7th-15th centuries, Rome, Italy)

Who were the miners of Allumiere? A multidisciplinary approach to reconstruct the osteobiography of an Italian worker community

The Phytochemical Constitution of Maltese Medicinal Plants – Propagation, Isolation and Pharmacological Testing

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