Pharmacological Data and Technical Feasibility of Intraperitoneal 5-Fluorouracil Administration

Abstract

Via a surgically implanted Tenckhoff catheter, 5-fluorouracil was intraperitoneally administered to patients with malignant disease confined to abdominal space. Treatment was well tolerated without local complications. Peritoneal and plasmatic drug levels were measured, showing that: 1) peritoneal drug levels declined as a first order function; 2) plasmatic levels were very close to those reported for continuous i.v. administration, but peritoneal concentrations were much higher (log 1 to 3); 3) concentration x time product had a peritoneum: plasma ratio ranging from 120 to 1350. The hypothesized role of intraperitoneal 5-fluorouracil administration and the questions still to be answered are summarized.

Surgical Debulking and Intraperitoneal Chemotherapy for Established Peritoneal Metastases From Colon and Appendix Cancer

“…[3][4][5][6] Hyperthermic perfusion of the peritoneal cavity with a heated (42°C) solution containing either cisplatin or mitomycin has been performed in colorectal cancer patients. The perfusion is typically performed in the operating room under general anesthesia for 60 to 90 minutes.…”