Pharmacological correction of the hemostasis system for the surgical treatment of bitches with tumours of the mammary gland

Bely, D. D.; Rublenko, M.; Rublenko, S.; Yevtushenko, I. D.; Suslova, N. I.; Samoyuluk, V. V.

doi:10.15421/021852

Cited by 3 publications

(4 citation statements)

References 38 publications

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“…В останні роки особлива увага приділяється дослідженням, які проводяться в напрямку створення надійних методів діагностики пухлин молочної залози; визначення шляхів розповсюдження у дрібних домашніх тварин і розробки науково-обґрунтованої системи боротьби з пухлинами й ефективних методів лікування тварин (Itoh et al, 2005;Baştan et al, 2009;Martí, 2009;Zon et al, 2013;Shafiee et al, 2013;Samoiliuk et al, 2014;Yesina et al, 2015;Mysaket al, 2016;Bely et al, 2018;Leong et al, 2018;Bilyi, 2019;Bіlyi et al, 2021).…”

Section: вступunclassified

“…Допоміжні діагностичні тести, які використовуються для оцінки уражень молочної залози самок дрібних домашніх тварин, включають ретельну оцінку стану здоров'я разом з повним клінічним обстеженням, загальний аналіз крові, біохімічний профіль сироватки, візуалізацію, цитологію та гістопатологію (Pérez-Alenza et al, 2004;Itoh et al, 2005;Martí, 2009;Zon et al, 2013;Shafiee et al, 2013;Yesina et al, 2015;Bely et al, 2018;Leong et al, 2018;Bilyi, 2019;Bіlyi et al, 2021).…”

Section: результати та їх обговоренняunclassified

“…У групі ризику перебувають тварини віком понад сім років. Новоутворення розвиваються в основному на найбільш функціональній та активній 4 та 5 парі молочних залоз, значно рідше -на 1 та 2 парі (Bely et al, 2018;Vasiu et al, 2021;Bilyi & Khomutenko, 2024).…”

Section: результати та їх обговоренняunclassified

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Organopathology of the mammary gland in female carnivores: current state of research issues

Koreyba,

Masyuk,

Skliarov

et al. 2024

SMLNUVMB

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The article presents the results of studies on the prevalence of mammary gland lesions in cats and dogs in veterinary hospitals of the city of Dnipro and associated with a wide range of pathological processes. Pathological processes (neoplastic, hyperplastic, inflammatory) in the mammary gland, in case of untimely diagnosis and treatment, give rise to the development of neoplasms, which are mostly malignant and manifest as adenocarcinoma, lymphoma, sarcoma, and carcinoma. Studies of mammary gland organopathology in female carnivores have shown that among mammary gland diseases in female pets, adenocarcinoma and adenoma (38 % and 10 %, respectively), lymphoma and sarcoma (2 % and 3 %, respectively), mastopathy (5–7 %), mastitis (10 %), and agalactia (1 3 %) were recorded. In cats aged 5 to 10 years and older, the tumour process is predominantly malignant, with an intensive and rapid course. Dogs aged 5 to 10 years are at risk of developing both non-malignant and malignant mammary tumours. In dogs over 10 years of age, malignant and benign mammary tumours are detected with equal frequency. Adenoma and fibroadenoma are more commonly recorded types of benign mammary neoplasms, and malignant processes are recorded in the form of adenocarcinoma, carcinoma, lymphoma, and sarcoma in cats and dogs. Adenocarcinomas are the most common malignant tumours of the breast. Carcinomas, lymphomas, and sarcomas are recorded to a lesser extent. Adenocarcinoma and mastopathy are more common in cats than in dogs. In dogs, cases of benign fibrocystic mastopathy are reported. It has been proven that in small animals, a combination of imaging methods (ultrasound, computed tomography, and radiography) is advisable for more accurate diagnosis and differential diagnosis of mammary tumours, which assess the size of the tumour, its vascularization, and characteristics. In any case, the diagnosis is confirmed by laboratory methods (morphological examination). The morphological studies of the affected mammary tissues allowed us to diagnose and structure tumour diseases, compare the data obtained with the results of a clinical study, and clarify the main clinical and morphological criteria for verifying the diagnosis.

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Section: результати та їх обговоренняunclassified

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Organopathology of the mammary gland in female carnivores: current state of research issues

Koreyba,

Masyuk,

Skliarov

et al. 2024

SMLNUVMB

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“…Taking into account the established patterns of violation of hemostatic balance, endothelial function and the presence of other paraneoplastic syndromes in dogs with neoplasms of the breast (Bely et al, 2018), we studied the characteristics of their changes at different sizes of tumour foci.…”

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confidence: 99%

Breast tumour size as a predictor of hemostatic system status and endothelial function in dogs

Bely

Rublenko

Smoyuluk

et al. 2019

Regul. Mech. Biosyst.

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The high level of morbidity of dogs from mammary gland tumours and deficiencies in the pathogenesis give relevance to study of the disorders of the hemostatic system for predicting the neoplasia process. Our research concerned the determination of markers of the hemostatic system and endothelial function at different sizes (≤ 2, 5–7 and >10 cm) of benign (n = 28) and malignant (n = 27) breast tumours in dogs, taking into account their histological structure. The progression of the tumour process was accompanied by a 1.24–1.81 times increase in the fibrinogen content in the benign forms and 1.39–2.38 times in malignant against the background of progressive excess accumulation of soluble fibrin. The results of coagulation tests indicate that the increase in blood coagulation, which correlates with the magnitude of tumours, occurred mainly externally. In malignant neoplasms reliable, compared to clinically healthy dogs, reduction of total fibrinolytic activity occurred due to deficient inhibition of tissue plasminogen activator by 1.62–2.03 times. Increase in the size of benign neoplasms was accompanied by increased activity of the α1-inhibitor of proteinases, and in malignant – only in tumours of the size of 5–7 cm, against the background of its decrease in dogs with small and giant neoplasia. The progression of the disease was characterized by an increase in the content of α2-macroglobulin in benign lesions from 1.19–1.24 times, malignant – from 1.25–2.03 times. At the same time, there was a deepening of oxidative stress, as evidenced by the excess accumulation in the blood of malondialdehyde by 1.29–1.70 times in benign tumours, and 1.58–2.73 times in malignant. Regardless of the pathomorphologic form, the magnitude of the neoplasia foci is directly correlated with excess accumulation of nitric oxide and the level of hypoproteinemia, and vice versa – the content of ceruloplasmin. Further research should be undertaken to study the hemostatic status in certain nosological forms of breast tumours in dogs, which will improve the diagnosis and development of effective treatment protocols.

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Perspective directions of bitches conservative treatment with breast tumors (review information)

Bilyi

Rublenko

Samoilіuk

et al. 2021

Nauk. vìsn. vet. med.

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The problem of treating tumors in dogs remains relevant due to the complexity of pathogenetic cascades, lack of common methodological approaches to diagnosis and treatment of cancer patients, insufficient number of animals in groups, the described nature of the results, incorrect "mechanical" borrowing of therapeutic protocols from human medicine. The proposed treatment regimens do not provide the desired results, there is a steady trend to increase the number of small pets with breast tumors. Therefore, it is important to find alternative treatments for dogs with breast neoplasms, among which, first of all, should be noted the use of nonsteroidal anti-inflammatory drugs, which cause a positive effect by inhibiting the expression of cyclooxygenase-2, activating apoptosis and inhibiting cancer cell migration. Potentially effective therapeutic methods are electroporation and electrochemotherapy, which can significantly increase the concentration of chemotherapeutic agents in cancer cells against the background of minimal toxicity to healthy tissues. The important role of hypercoagulation in the mechanisms of development and progression of breast tumors in dogs justifies the use of antithrombotic therapy in cancer patients, especially low molecular weight heparins, which can improve the effectiveness of therapeutic protocols and prevent tumor metastasis. It is shown that these methods as part of complex treatment regimens increase the effectiveness of conventional protocols of chemotherapy and radiation therapy, as well as surgery. However, further studies of the pathogenetic aspects of these treatments for breast tumors in bitches and the possibility of combining them with other therapeutic regimens are needed. Key words: bitches, breast neoplasms, treatment protocols, nonsteroidal anti-inflammatory drugs, electroporation, antithrombotic therapy.

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Pharmacological correction of the hemostasis system for the surgical treatment of bitches with tumours of the mammary gland

Cited by 3 publications

References 38 publications

Organopathology of the mammary gland in female carnivores: current state of research issues

Organopathology of the mammary gland in female carnivores: current state of research issues

Breast tumour size as a predictor of hemostatic system status and endothelial function in dogs

Perspective directions of bitches conservative treatment with breast tumors (review information)

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