Pharmacological Control of Reproduction in Women

Evidence for the Involvement of a Catecholaminergic Pathway in Gonadotrophin Secretion for Implantation in Rats

“…The known ability of haloperidol to interfere with dopaminergic trans¬ mission (Yeh et al, 1969) and reduce gonadotrophin release (Schneider & Mc¬ Cann, 1970) implies that secretion of gonadotrophins for oestrogen surge preceding implantation is regulated by a catecholaminergic pathway. It is possible that the antifertility property of some monoamine oxidase inhibitors (Poulson & Robson, 1964;Harper, 1968), or tranquillizers (Psychoyos, 1968) when given during the period of implantation may be mediated, at least partly, through their ability to modify catecholaminergic transmission in the central nervous system with a consequent inhibition or attenuation of a gonadotrophin-dependent oestrogen surge.…”