Pharmacological Control of Asthma

Wilson, and A F; McPhillips, Joseph J.

doi:10.1146/annurev.pa.18.040178.002545

Cited by 23 publications

(3 citation statements)

References 48 publications

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“…With the aim of verifying this hypothesis, we checked whether or not /~-adrenergic agonists, such as fenoterol and salbutamol, currently used for the pharmacological control of asthma [28], could affect human neutrophil activity. Furthermore, we thought it worthwhile not only to compare PGE 1 and histamine effects to those of isoprenaiine but also to evaluate whether or not these substances could interact in the same cell population.…”

Section: Introductionmentioning

confidence: 99%

Autacoid andβ-adrenergic agonist modulation of N-formylmethionyl-leucyl-phenylalanine evoked lysosomal enzyme release from human neutrophils

et al. 1984

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Section: Introductionmentioning

confidence: 99%

Autacoid andβ-adrenergic agonist modulation of N-formylmethionyl-leucyl-phenylalanine evoked lysosomal enzyme release from human neutrophils

et al. 1984

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“…It has been demonstrated recently that the dosage of theophylline, based on ä widely used body weight-derived formula (5), is unreliable and can be dangerous (6,7), as there is a wide variation in the rate of metabolism of this compound (8). Patients with hepatic disease such as liver cirrhosis, show a slow and variable metabolism of theophylline, as about ninety percent of this drug is metabolized in the liver (9).…”

Section: Introductionmentioning

confidence: 99%

“…Monitoring of serum theophylline levels has therefore been increasingly recommended in recent years (7,(11)(12)(13)(14)(15). Usually, serum levels of theophylline between 10 and 20 mg/1 provide substantial improvements in pulmonary function with minimal toxicity (8). In premature infants, serum concentrations of 6 to 11 mg/1 are necessary to control apnoeic spells (11).…”

Section: Introductionmentioning

confidence: 99%

Monitoring of Serum Theophylline Concentrations by a Fully Mechanized Enzyme Immunoassay (EMIT)

Oellerich¹,

Gw²,

Haeckel³

1979

Clinical Chemistry and Laboratory Medicine

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Summary: An evaluation of an enzyme immunoassay for the determination of theophylline in serum (EMIT, Syva Corp.) is presented. The EMIT assay was fully mechanized by the use of an Eppendorf analyzer 5010. The precision of this enzyme immunoassay was satisfactory (coefficients of variation from day to day ranged from 5-6%). The EMIT assay proved to be specific, rapid and easy to perform. A comparison of the results obtained by EMIT and ultraviolet spectrophotometry in a series of 100 patients showed a good correlation between both methods. Überwachung der Theophyllinkonzentration im Serum mit einem vollmechanisierten Enzymimmunotest (EMIT)Zusammenfassung: Es wird über die Erprobung eines Enzymimmunotests zur Bestimmung von Theophyllin im Serum (EMIT, Syva Corp.) berichtet. Der EMIT-Test wurde mit Hilfe eines Eppendorf Enzymautomaten 5010 vollmechanisiert. Die Präzision dieses Enzymimmunotests war zufriedenstellend (die Variationskoeffizienten von Tag zu Tag lagen bei 5-6%). Der EMIT-Test erwies sich als spezifisch sowie rasch und einfach durchführbar. Ein Vergleich der Ergebnisse, welche mit EMIT und einer UV-Methode bei einer Serie von 100 Patienten erhalten wurden, ergab eine gute Übereinstimmung beider Verfahren.

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Clinical aerosols II. Therapeutic aerosols

Lourenço¹

1982

Archives of Internal Medicine

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The current uses of clinical aerosols such as water, saline, mucolytics, bronchodilators, cromolyn sodium, corticosteroids, and antimicrobials have been reviewed. The benefits of water, saline, and detergent aerosols continue to be surrounded by uncertainty and controversy. Aerosolized mucolytic and proteolytic agents have not been conclusively shown to be of substantial value in the improvement of respiratory disorders. Favorable bronchodilator therapy is achieved with aerosols of certain sympathomimetic and anticholinergic agents. However, successful therapy depends on the dose administered and the site of aerosol deposition in the lung. The prophylactic use of cromolyn sodium in patients with asthma is another useful application of aerosols. Topically active corticosteroid aerosols are increasingly being used since they may reduce risks of systemic effects from corticosteroids. Research on uncommonly aerosolized agents has widened the spectrum of therapeutic applications of aerosols.

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Pharmacological Control of Asthma

Cited by 23 publications

References 48 publications

Autacoid andβ-adrenergic agonist modulation of N-formylmethionyl-leucyl-phenylalanine evoked lysosomal enzyme release from human neutrophils

Autacoid andβ-adrenergic agonist modulation of N-formylmethionyl-leucyl-phenylalanine evoked lysosomal enzyme release from human neutrophils

Monitoring of Serum Theophylline Concentrations by a Fully Mechanized Enzyme Immunoassay (EMIT)

Clinical aerosols II. Therapeutic aerosols

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